A5020587925- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Grief, Bereavement, and Mental Health
- Religion, Spirituality, and Psychology
- Palliative Care and End-of-Life Issues
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cancer-related cognitive impairment studies
- Genomics and Rare Diseases
- Management of metastatic bone disease
- Cancer survivorship and care
- Single-cell and spatial transcriptomics
- Meningioma and schwannoma management
- Advanced MRI Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- 3D Printing in Biomedical Research
- Medical Imaging Techniques and Applications
- NF-κB Signaling Pathways
- Functional Brain Connectivity Studies
- Cancer Cells and Metastasis
- Advanced Neuroimaging Techniques and Applications
- Nausea and vomiting management
- Intensive Care Unit Cognitive Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Peptidase Inhibition and Analysis
University Hospital Regensburg
2009-2025
University of Regensburg
2006-2020
Integrated Oncology (United States)
2017
RWTH Aachen University
2017
CYLD was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Recent studies suggested role for nuclear factor-kappaB (NF-κB) regulation. NF-κB activation has been connected with multiple aspects of oncogenesis but the underlying molecular mechanisms persistent tumors remain largely unknown. Thus, we evaluated transcription different colon and hepatocellular carcinoma cell lines tissue samples, respectively. downregulated or lost all investigated compared...
BackgroundMedian survival with glioblastoma remains in the range of 12 months on population levels. Only few patients survive for more than 5 years. Patient and disease features associated long-term remain poorly defined.MethodsEuropean Organization Research Treatment Cancer (EORTC) 1419 (ETERNITY) is a registry study supported by Brain Tumor Funders Collaborative US EORTC Group. Patients surviving at least years from diagnosis were identified 24 sites Europe, US, Australia. In isocitrate...
Abstract This paper investigates the nurses’ gatekeeping role for spiritual care in multi-disciplinary teams as a way of responding to needs patients with brain tumors Austria. Using validated vignette an online survey, qualitative data from 56 neurosurgical nurses (30.4% response rate) were analyzed via reflexive thematic analysis. One key theme, Nurses Gatekeepers – Referral and Working other Health Care Professionals , highlights critical care. Effective referrals depend on awareness...
Abstract Purpose Neuro-oncology tumor boards (NTBs) hold an established function in cancer care as multidisciplinary boards. However, NTBs predominantly exist at academic and/or specialized centers. In addition to increasing centralization throughout the healthcare system, changes due COVID-19 pandemic have arguably resulted advantages by conducting clinical meetings virtually. We therefore asked about experience and acceptance of (virtualized) their potential benefits. Methods A survey...
Abstract Purpose People with primary malignant brain tumors experience serious health-related suffering caused by limited prognosis and high symptom burden. Consequently, neuro-oncological healthcare workers can be affected emotionally in a negative way. The aim of this study was to analyze the attitudes behavior nurses physicians when confronted spiritual distress these patients. Methods Neurospirit-DE is qualitative vignette–based, multicenter, cross-sectional online survey that conducted...
Isocitrate dehydrogenase (IDH)-1 mutation is an important prognostic factor and a potential therapeutic target in glioma. Immunohistological molecular diagnosis of IDH status invasive. To avoid tumor biopsy, dedicated spectroscopic techniques have been proposed to detect D-2-hydroxyglutarate (2-HG), the main metabolite IDH, directly vivo. However, these methods are technically challenging not broadly available. Therefore, we explored use machine learning for non-invasive, inexpensive fast...
Abstract Background Recently, molecular tumour boards (MTBs) have been integrated into the clinical routine. Since their benefit remains debated, we assessed MTB outcomes in Comprehensive Cancer Center Ostbayern (CCCO) from 2019 to 2021. Methods and results In total, 251 patients were included. Targeted sequencing was performed with PCR MSI-evaluation immunohistochemistry for PD-L1, Her2, mismatch repair enzymes. 125 treatment recommendations given (49.8%). High-recommendation rates achieved...
Abstract Recent updates in the classification of central nervous system (CNS) tumors have increased need for molecular testing. Assessment multiple alterations parallel, complex combinations gene sequence and chromosomal changes, as well therapy prediction by identification actionable mutations are major challenges. We here report on a customized next generation sequencing (NGS)-based DNA panel assay that combines diagnostic predictive testing -as comprehensive approach- allows simultaneous...
Abstract Background Combined radiochemotherapy followed by maintenance chemotherapy with cisplatin, lomustine and vincristine within the NOA-07 study resulted in considerable short-term toxicity adult medulloblastoma patients. Here we investigated long-term impact of this treatment, focusing on neurocognitive functioning health-related quality life (HRQoL). Methods Neurocognitive HRQoL scores over time were determined, differences between post-treatment follow-up assessments calculated up to...
Abstract Background The randomized phase 3 CeTeG/NOA-09 trial assessed whether CCNU plus temozolomide was superior to alone in newly diagnosed MGMT promoter methylated glioblastoma patients. Survival significantly improved from 31.4 months (temozolomide) 48.1 (CCNU temozolomide). In view of this encouraging data, we safety and efficacy regimen under real-life conditions. Methods We retrospectively collected clinical radiographic data adult IDH wildtype patients five neuro-oncology centers...
Conventional 2D cultures are commonly used in cancer research though they come with limitations such as the lack of microenvironment or reduced cell heterogeneity. In this study, we investigated what respect a scaffold-based (Matrigel™) 3D culture technique can ameliorate cultures. NGS-based bulk and single-cell sequencing matched pairs models showed an altered transcription key immune regulatory genes around 36% models, indicating reoccurrence suppressive phenotype. Changes included...
Abstract Aims To discuss the construction and use of vignettes as a novel approach in spiritual care research education. Design Methods paper. In this methods paper, authors introduce provide insight into vignettes. The vignette presented was part study neurosurgical nurses' attitudes responses to needs neuro‐oncology patients. development process, consisting four steps, is explained Results Using explore towards an innovative way understand what behaviours nurses consider appropriate...
Abstract Background The prognosis of patients with brain tumors is widely varying. Psychooncologic need and depression are high among these their family caregivers. However, the for counselling referral to psychooncology care often underestimated. Methods We performed a single-institution cross-sectional study evaluate psychooncologic need, information in both Hornheider Screening Instrument (HSI) Patient Health Questionnaire (PHQ-9) were used depression, study-specific questionnaire was...
Abstract People with primary brain tumors face spiritual challenges due to neuro-cognitive disturbances such as aphasia and rapid neurological deterioration. This scoping review aimed map the evidence regarding professional care in this neuro-oncological population. The literature search was conducted utilizing two databases (PubMed, CINAHL) peer-reviewed journals (‘Spiritual Care’, ‘Journal of Religion Health’). In total, 27 studies were analyzed, five thematic categories identified: (1)...
Die Frühsommer-Meningo-Enzephalitis (FSME) ist die häufigste vektorübertragene virale Enzephalitis Mittel- und Osteuropas. Eine Liquor-Pleozytose wurde bei allen bisher publizierten Fällen beobachtet. Da eine Pleozytose jedoch meist zur Falldefinition der Erkrankung herangezogen wird, Häufigkeit von FSME-Fällen ohne unklar. Wir berichten über 2 Fälle einer schweren, immunologisch gesicherten myelitischen FSME, keine zeigten. Bei unauffälliger Liquor-Zellzahl FSME-verdächtiger klinischer...
We report the case of a 40-year-old woman with progressive right-sided hemiparesis. Standard MRI revealed contrast-enhancing brain lesion within left basal ganglia. Ffluoroethyl-L-tyrosine (F-FET) PET showed distinct tracer uptake (lesion-to-brain ratio [LBR]: LBRmax = 2.03, LBRmean 1.68) significant larger metabolic volume than contrast-enhancement in MRI, indicating cerebral glioma. Surprisingly, histopathologic analysis demonstrated central nervous system toxoplasmosis pronounced...
In recent years, onco-metabolites like D-2-hydroxyglutarate, which is produced in isocitrate dehydrogenase-mutated tumors, have gained increasing interest. Here, we report a metabolite human specimens that closely related to 2-hydroxyglutarate: the intramolecular ester of 2-hydroxyglutarate, 2-hydroxyglutarate-γ-lactone. Using 13C5-L-glutamine tracer analysis, showed 2-hydroxyglutarate endogenous precursor 2-hydroxyglutarate-lactone and there high exchange between these two metabolites....
Functional magnetic resonance imaging (fMRI) is a valuable tool in the clinical routine of neurosurgery when planning surgical interventions and assessing risk postoperative functional deficits. Here, we examined how presence brain tumor or lesion area occipital lobe affects results fMRI retinotopic mapping. data were evaluated on retrospectively selected sample 12 patients with tumors, 7 lesions 19 control subjects. Analyses cortical activation, percent signal change, cluster size activated...
Glioma patients face a limited life expectancy and at the same time, they suffer from afflicting symptoms undesired effects of tumor treatment. Apart bone marrow suppression, standard chemotherapy with temozolomide causes nausea, emesis loss appetite. In this pilot study, we investigated how chemotherapy-induced nausea vomiting (CINV) affects patients' levels depression their quality life.In prospective observational multicentre study (n = 87), appetite were evaluated an expanded MASCC...
The isocitrate dehydrogenase (IDH) mutation status is an indispensable prerequisite for diagnosis of glioma (astrocytoma and oligodendroglioma) according to the WHO classification brain tumors 2021 a potential therapeutic target. Usually, immunohistochemistry followed by sequencing tumor tissue performed this purpose. In clinical routine, however, non-invasive determination IDH desirable in cases where biopsy not possible monitoring neuro-oncological therapies. previous publication, we...
Malignant isocitrate dehydrogenase wild-type (IDHwt) gliomas impose a high symptomatic and psychological burden. Wide distances from patients' homes to cancer centers may affect the delivery of psycho-oncological care. Here, we investigated, in large brain tumor center with rural outreach, initiation care depending on spatial distance impact emergency visits.Electronic patient charts, regional registry, interviews primary physicians were used investigate clinical data, care, unit visits....
Patients with glioblastoma are exposed to severe symptoms and organs failures (e.g., coma or acute respiratory failure), that may require intensive care unit (ICU) admission invasive mechanical ventilation (IMV). However, only limited data available concerning the prognosis of patients receiving IMV. We sought describe reasons for ICU admission, outcomes requiring IMV unplanned critical complications.In this retrospective analysis, four certified interdisciplinary brain tumor centers...
(1) Background—Mapping language using direct cortical stimulation (DCS) during an awake craniotomy is difficult without more than one paradigm that particularly follows the demand of DCS by not exceeding assessment time 4 s to prevent intraoperative complications. We designed combining classical picture naming and verb generation, which safely engaged highly relevant functions. (2) Methods—An evaluation study investigated whether a single trial task could be performed in less 30 healthy...