A5060229440- Acute Ischemic Stroke Management
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Cardiac pacing and defibrillation studies
- COVID-19 and Mental Health
- Gastric Cancer Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Retinal Imaging and Analysis
- COVID-19 epidemiological studies
- Atherosclerosis and Cardiovascular Diseases
- Pediatric Pain Management Techniques
- Health disparities and outcomes
- Neurological Disorders and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
- Esophageal Cancer Research and Treatment
- Autoimmune and Inflammatory Disorders Research
King's College London
2021-2024
William Harvey Research Institute
2023-2024
Queen Mary University of London
2024
Barts Health NHS Trust
2024
King University
2023
Nottingham Biomedical Research Centre
2021
University of Nottingham
2016-2021
Nottingham University Hospitals NHS Trust
2021
University College London
2019-2020
University of Kentucky
2011
Contrast-induced nephropathy (CIN), also known as contrast-associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity and mortality following coronary angiographic procedures in high-risk patients remains unmet need. In pre-clinical studies inorganic nitrate, which is chemically reduced vivo to nitric oxide, renoprotective but this observation yet be translated clinically. study, efficacy nitrate prevention CIN presenting with syndromes (ACS) reported.
Introduction Recent years have witnessed an upsurge of demand in eye care services the UK. With a large proportion patients referred to Hospital Eye Services (HES) for diagnostics and disease management, referral process results unnecessary referrals from erroneous diagnoses delays access appropriate treatment. A potential solution is teleophthalmology digital pathway linking community optometry HES. Methods analysis The HERMES study (Teleophthalmology-enabled artificial intelligence-ready...
Background Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best for treatment of ischemic heart disease, has also been investigated its potential therapeutic benefit in stroke. The completed Efficacy Nitric Oxide Stroke trial suggested that GTN with acute (within 6 hours) transdermal systemic sustained release therapy. Objective To examine an alternative use therapy stroke following successful recanalization. Methods We administered IA transient middle cerebral artery...
Pain is the most debilitating symptom in juvenile idiopathic arthritis. As pain correlates poorly to extent of joint pathology, therapies that control inflammation are often inadequate as analgesics. We test hypothesis leads sensitisation nociceptive circuits central nervous system, which maintained by cytokine expression spinal cord. Here, transient was induced postnatal day (P)21 and P40 male Sprague-Dawley rats with a single intra-articular ankle injection complete Freund's adjuvant....
Abstract Patients with cirrhosis have reduced gut-bacterial diversity and microbiota enriched pathobionts. This enrichment, coupled increased gut permeability bacterial translocation, increases susceptibility to infection death. Faecal transplant [FMT] previously restored improved hepatic encephalopathy (HE) in small phase-I-trials, but its impact upon the disease process is unexplored. We performed a randomised, placebo-controlled feasibility trial of jejunal FMT 32 advanced patients. The...
Obesity drives type 2 diabetes (T2DM) development. Laparoscopic adjustable gastric banding (LAGB) has lower weight reduction than other bariatric procedures. Liraglutide, a GLP-1 receptor agonist, improves and glycaemic control in patients with T2DM. This study aimed to determine the efficacy safety of liraglutide 1.8 mg participants undergoing LAGB.
Abstract Background Kidney transplantation is the gold-standard treatment for patients with kidney failure. However, one-third of awaiting a transplant are highly sensitized to human leukocyte antigens (HLA), resulting in an increased waiting time suitable kidney, more acute and chronic rejection, shorter graft survival compared non-highly sensitised patients. Current standard immunosuppression protocols do not adequately suppress memory responses, so alternative strategies needed....
Abstract Background Throughout the Covid-19 pandemic, researchers have made use of electronic health records to research this disease in a rapidly evolving environment questions and discoveries. These studies are prone collider bias as they restrict population patients only those with severe disease. Inverse probability weighting is typically used correct for but requires information from unrestricted population. Using South London NHS trust, work demonstrates method using externally sourced...
BACKGROUND: In patients with previous coronary artery bypass grafting, computed tomography cardiac angiography (CTCA) before invasive (ICA) was demonstrated in the BYPASS-CTCA trial (Randomized Controlled Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Bypass Surgery Patients) reduce procedure time and incidence of contrast-associated acute kidney injury, greater levels patient satisfaction. Patient-related outcomes, utilization further...
We aimed to identify and characterise the longitudinal patterns of multimorbidity associated with stroke. used an unsupervised patient-oriented clustering approach analyse primary care electronic health records (EHR) 30 common long-term conditions (LTC) in patients stroke aged over 18, registered 41 general practices south London between 2005 2021. Of 849,968 patients, 9,847 (1.16%) had a record 46.5% were female. The median age at was 65.0 year (IQR: 51.5-77.0) number LTCs addition 3 2-5)....
Patients with non-severe ANCA-associated vasculitis (AAV) are often prescribed immunosuppressive medications that associated severe side effects and a reduced quality of life. There is an unmet need for safer effective treatments these patients. Hydroxychloroquine being explored due to its effect in similar autoimmune conditions such as systemic lupus erythematosus.Double-blind, placebo-controlled multicentre trial recruiting 76 patients across 20 sites. Participants will be randomised 1:1...
Studies from the first waves of coronavirus disease 2019 (COVID-19) pandemic suggest that individuals minority ethnicities are at an increased risk worse outcomes. Concerns exist this relationship is potentially driven by bias analyzing hospitalized patients only. We investigate and possible presence bias.Using data South London hospitals across two COVID-19 (February 2020 - May 2021), between ethnicity outcomes was examined using regression models. Three iterations each model were...
While pain is a common symptom in JIA patients, it remains unclear why some patients develop ongoing or persistent pain. Complex clinical and social settings confound analysis of individual factors that may contribute to this To address this, we first undertook retrospective reports patient cohort with the aim identifying potential contributing We then carried out an experimental laboratory study, using joint inflammatory behaviour rodents, validate role these onset under controlled...
Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow infarct expansion. This study sought to determine the effect of glyceryl trinitrate (GTN) treatment in both lissencephalic gyrencephalic pre-clinical stroke models. Merino sheep underwent middle artery occlusion (MCAO) followed by GTN or control patch...
Management of age-related macular degeneration (AMD) places a high demand on already constrained hospital-based eye services. This study aims to assess the safety and quality follow-up within community led by suitably trained non-medical practitioners for management quiescent neovascular AMD (QnAMD).This is prospective, multisite, randomised clinical trial. 742 participants with QnAMD will be recruited either continue secondary care or receive setting. Participants in both groups monitored...
Background: Identifying and characterising the longitudinal patterns of multimorbidity associated with stroke is needed to better understand patients' needs inform new models care. Methods: We used an unsupervised patient-oriented clustering approach analyse primary care electronic health records (EHR) 30 common long-term conditions (LTC), in patients aged over 18, registered 41 general practices south London between 2005 2021. Results: Of 849,968 patients, 9,847 (1.16%) had a record stroke,...