A5062805306- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Dendrimers and Hyperbranched Polymers
- Bat Biology and Ecology Studies
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Adipose Tissue and Metabolism
- Physiological and biochemical adaptations
- Neurological Disease Mechanisms and Treatments
- Physical Education and Training Studies
- Natural Compounds in Disease Treatment
- Photodynamic Therapy Research Studies
- Pancreatic and Hepatic Oncology Research
- Sphingolipid Metabolism and Signaling
- Endoplasmic Reticulum Stress and Disease
- Acute Ischemic Stroke Management
Hokkaido University
2016-2024
Hokkaido University of Science
2016-2024
Okayama University
1959-2014
Japan Society for the Promotion of Science
2014
High concentrations of antioxidants in cancer cells are huge obstacle radiotherapy. Erastin was first discovered as an inducer iron-dependent cell death called ferroptosis accompanied by antioxidant depletion caused cystine glutamate antiporter inhibition. Therefore, treatment with erastin is expected to potentially enhance cellular radiosensitivity. In this study, we investigated the influence on radiation efficiency against cancers. The clonogenic ability, glutathione peroxidase 4 (GPX4)...
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) targeted therapy by anti-CTLA-4 monoclonal antibody (mAb) is highly effective in cancer patients. However, it extremely expensive and potentially produces autoimmune-related adverse effects. Therefore, the development of a method to evaluate CTLA-4 expression prior CTLA-4-targeted expected open doors evidence-based cost-efficient medical care avoid effects brought about ineffective therapy. In this study, we aimed develop molecular imaging...
Abstract Injury due to brain ischemia followed by reperfusion (I/R) may be an important therapeutic target in the era of thrombectomy. FTY720, a widely known sphingosine-1-phosphate receptor agonist, exerts various neuroprotective effects. The aim this study was examine protective effect FTY720 with respect I/R injury, especially focusing on blood–brain barrier (BBB) protection and anti-inflammatory Male rats were subjected transient administered vehicle or 0.5 1.5 mg/kg immediately before...
Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial role abnormalities, but the pathogenic mechanism remains unclear. Xanthine oxidase (XO) reported be an important mediator of ROS overproduction ischaemic tissue. Here, we tested hypothesis abnormalities HF are initially caused by XO-derived and prevented inhibition their production.
To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[18F]-fluoropropyl)-2-nitroimidazole ([18F]DiFA) as new tracer that targets tumor with its lower lipophilicity and efficient radiosynthesis. Here, evaluated the radiation dosage, biodistribution, human safety, tolerability, early elimination after injection of [18F]DiFA healthy subjects, performed preliminary study patients malignant tumors comparison [18F]fluoromisonidazole ([18F]FMISO). The single...
Programmed cell death 1 (PD-1) inhibitors act as immune checkpoint and are more effective for improving survival time with less toxicity compared conventional chemotherapies. In anti PD-1 therapy, it is important to evaluate metabolism in the cancer microenvironment, this helps clarify pathological conditions. Herein, we investigate early effects of therapy on 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) uptake vivo, focusing distribution glycolysis both cells. a B16F10 melanoma model,...
The potential application of bone marrow stromal cell (BMSC) therapy in stroke has been anticipated due to its immunomodulatory effects. Recently, positron emission tomography (PET) with [18F]DPA-714, a translocator protein (TSPO) ligand, become available for use as neural inflammatory indicator. We aimed evaluate the effects BMSC administration after transient middle cerebral artery occlusion (MCAO) using [18F]DPA-714 PET. BMSCs or vehicle were administered intravenously rat MCAO models at...
Eribulin, an inhibitor of microtubule dynamics, shows antitumor potency against a variety solid cancers through its antivascular activity and remodeling tumor vasculature. 18F-Fluoromisonidazole (18F-FMISO) is the most widely used PET probe for imaging hypoxia. In this study, we utilized 18F-FMISO to clarify effects eribulin on hypoxic condition in comparison with histological findings.Mice bearing human cancer cell xenograft were intraperitoneally administered single dose (0.3 or 1.0 mg/kg)...
Abstract The naked mole-rat (NMR) is a heterothermic mammal that forms eusocial colonies consisting of one reproductive female (queen), several males, and subordinates. Despite their heterothermy, NMRs possess brown adipose tissue (BAT), which generally induces thermogenesis in cold some non-cold environments. Previous studies suggest NMR-BAT by exposure. However, detailed characteristics whether occurs environments are unknown. Here, we show beta-3 adrenergic receptor (ADRB3)-dependent...
Delivery systems to lymph node-resident T cells around tumor tissues are essential for cancer immunotherapy, in order boost the immune responses. We previously reported that anionic dendrimers, such as carboxyl-, sulfonyl-, and phosphate-terminal were efficiently accumulated nodes via intradermal injection. Depending on terminal structure, their cell association properties different, carboxyl-terminal dendrimers did not associate with any majorly. In this study, we investigated delivery of...
Sorafenib, an oral multikinase inhibitor, has anti-proliferative and anti-angiogenic activities is therapeutically effective against renal cell carcinoma (RCC). Recently, we have evaluated the tumor responses to sorafenib treatment in a RCC xenograft using [Methyl-3H(N)]-3'-fluoro-3'-deoxythythymidine ([3H]FLT). Contrary our expectation, FLT level significantly increased after treatment. In this study, clarify reason for elevated level, dynamic 3'-[18F]fluoro-3'-deoxythymidine ([18F]FLT)...
Ferroptosis induction has been recognized as a novel cancer therapeutic strategy. To effectively apply ferroptosis-targeting therapy to individual patients, diagnostic indicator for selecting this strategy from number of molecular targeting drugs is needed. However, date, methods that can predict the efficacy treatment have not established yet. In study, we focused on iron metabolic pathway develop nuclear imaging technique diagnosing susceptibility cells ferroptosis. As probe, human...
<title>Abstract</title> Purpose Non-alcoholic fatty liver disease (NAFLD) comprises simple steatosis (SS), which has a low risk of mortality, and non-alcoholic steatohepatitis (NASH), can progress to cirrhosis hepatocellular carcinoma. Because differentiation between NASH SS is the most important issue in diagnosis NAFLD, establishment noninvasive diagnostic methods urgently needed. In this study, we evaluated potential [<sup>123</sup>I]IIMU, thymidine phosphorylase (TYMP) targeted SPECT...
Measurement methods for iodine-derived contamination in L-[11C]methionine injection were evaluated. L-[11C]Methionine and samples from the mock synthesis routes where iodine vapor was introduced with or without passing precolumns of sodium hydroxide-coated silica (Ascarite columns) used. The contents total iodine, iodide ion, I2 determined by ICP-MS, HPLC-UV detection, N,N-diethyl-1,4 phenylenediamine method, respectively. Total measured ICP-MS indicated potentials Ascarite columns removing...
68Ge/68Gaジェネレータ(Galli Eo®, 1780 MBq)からの漏洩線量,溶出操作による放射性物質の飛散・漏洩,周辺の汚染を15ヵ月,作業者の被ばく線量を8ヵ月に亘って評価した。ジェネレータの最大表面線量は150 µSv/hであり,68Geの減衰に伴って低下した。放射性物質の飛散,周辺の汚染は検出されなかった。溶出操作時の作業者の被ばく線量は1溶出あたり5 µSv以下であった。以上,本ジェネレータの安全性が確認された。
bellowings of animals recorded in tape at the same level.This method was used practice and proved to be quite convenient effective.6.The variation hearing caused by incluence a noise studied under various degrees noises.From this, it is concluded that best way screen noises do so level fixed 5db stronger than average minimal threshold, previously obtained normal ears 1000cps noises.