A5063805259- Sperm and Testicular Function
- Cell Adhesion Molecules Research
- Reproductive Biology and Fertility
- Peptidase Inhibition and Analysis
- Hormonal Regulation and Hypertension
- Sexual Differentiation and Disorders
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Ovarian function and disorders
- Urological Disorders and Treatments
- Mitochondrial Function and Pathology
- Cardiovascular and exercise physiology
- Protease and Inhibitor Mechanisms
- Renal and Vascular Pathologies
- Cardiovascular Function and Risk Factors
- Testicular diseases and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Adrenal and Paraganglionic Tumors
- Protein Hydrolysis and Bioactive Peptides
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Cancer, Hypoxia, and Metabolism
- Glutathione Transferases and Polymorphisms
- Heart Failure Treatment and Management
- Pediatric Urology and Nephrology Studies
Hosei University
2022-2024
Japan Fisheries Research and Education Agency
2010-2022
Kumamoto University Hospital
2022
Tokeidai Memorial Hospital
2022
Hokkaido University
2016-2020
Tottori University
2020
Sumitomo Heavy Industries (Japan)
2020
Shinko Electric Industries (Japan)
2017-2019
Waseda University
2017
Okayama Prefecture
2016
Decreased exercise capacity, which is an independent predictor of the poor prognosis patients with heart failure (HF), attributed to markedly impaired skeletal muscle mitochondrial function and fatty acid oxidation. Previous studies reported that administration inhibitor sodium-glucose cotransporter 2 (SGLT2) increases ketone body production fat utilization in type diabetic mice. In this study, we investigated effects SGLT2 on endurance oxidation a murine model HF after induction myocardial...
Abstract Systemic oxidative stress plays a key role in the development of chronic heart failure (CHF). We tested hypothesis that mitochondrial reactive oxygen species (ROS) generation circulating peripheral blood mononuclear cells (PBMCs) contributes to CHF progression. A total 31 patients who had history hospital admission due worsening HF were enrolled and grouped as having either mild defined New York Heart Association (NYHA) functional class I-II or moderate-to-severe NYHA III. ROS...
Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial role abnormalities, but the pathogenic mechanism remains unclear. Xanthine oxidase (XO) reported be an important mediator of ROS overproduction ischaemic tissue. Here, we tested hypothesis abnormalities HF are initially caused by XO-derived and prevented inhibition their production.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRelease of Biological Activities from Quiescent Fibronectin by a Conformational Change and Limited Proteolysis Matrix MetalloproteinasesFumio Fukai, Mitsuru Ohtaki, Nozomi Fujii, Hirofumi Yajima, Tadahiro Ishii, Kaoru Miyazaki, Takashi KatayamaCite this: Biochemistry 1995, 34, 36, 11453–11459Publication Date (Print):September 12, 1995Publication History Published online1 May 2002Published inissue 12 September...
Intravenous drip infusion of PGE1 in man induced a marked increase GH secretion. Stimulation HGH secretion by administration is possibly explained the assumption direct or indirect action on anterior pituitary increasing cyclic AMP, consequently releasing HGH. appears to be useful as method testing secretory activity GH.
Abstract Background In fish breeding, it is essential to discover and generate exhibiting an effective phenotype for the aquaculture industry, but screening natural mutants by only depending on spontaneous mutations limited. Presently, reverse genetics has become important tool mutants, which exhibit caused inactivation of a gene. TILLING ( T argeting I nduced L ocal esions IN G enomes) strategy that combines random chemical mutagenesis with high-throughput discovery technologies induced in...
We recently found that fibronectin (FN) had a functional site [YTIYVIAL sequence in the heparin-binding domain 2 (Hep 2)] was capable of suppressing integrin-mediated cell adhesion to extracellular matrix. However, our results also indicated this anti-adhesive seemed be usually buried within Hep structure because its hydrophobic nature, raising question as physiological significance cryptic activity FN. The present study demonstrates can exposed through processes. A 30-kDa chymotryptic FN...
Abstract Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated association between mitochondrial respiratory capacity, adiponectin concentration EAT, and atherosclerosis. samples were obtained from 25 patients who underwent elective cardiac surgery. Based on angiographycal findings, divided into two groups; (CAD; n = 14) non-CAD (n 11) groups. The capacities...
Here, we show that fibronectin (FN) peptides derived from two distinct regions promote the insulin-induced adipocyte differentiation of ST-13 cells by preventing FN fibrillogenesis. formed numerous fibrils under nonadipogenic conditions, whereas this fibrillogenesis was suppressed adipose induction with insulin. The promoted an amino-terminal 24-kDa fragment FN, accompanied further suppression 24 K prevented matrix assembly direct incorporation into matrix. Like fragment, a peptide 14th type...
A case of headless or decapitated spermatozoa an infertile man is reported. The 33-year-old patient showed almost normal spermiogram except for a high percentage (more than 90%) spermatozoa. Both hypoosmotic swelling and zona-free hamster egg tests that most appeared to be in their function as tails. ultrastructure the ejaculated was observed using surface replica method by conventional ultrathin sectioning. were structure absence head. Tailless heads rarely observed. Varieties...
No AccessJournal of Urology1 Dec 1988Catecholamine Metabolism in Pheochromocytoma and Normal Adrenal Medullae Teruhiro Nakada, Hidekatsu Furuta, Takashi Katayama NakadaTeruhiro Nakada , FurutaHidekatsu Furuta KatayamaTakashi View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)42041-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The tissue contents catecholamine, its precursor major metabolites were...
Differentiation of ST-13 preadipocytes into adipocytes was inhibited almost completely by addition rat plasma fibronectin (FN) (approximately 100 micrograms/mL), but reversed GRGDSP cell recognition peptide (1.5 mM) and anti-alpha 5 beta 1. On the contrary, thermolysin digest FN stimulated adipocyte differentiation in a dose-dependent manner, which remarkable increases values indexes, number (8-fold above control), glycerophosphate dehydrogenase (GPD) activity (12-fold), triacylglycerol...
Mechanism of fibronectin (FN)-induced chemotaxis fibroblastic cells has not been fully understood. The present study was performed to establish a molecular nature the chemotactic region rat plasma FN. dose-response pattern intact FN for mouse embryo cells, NIH-L13 which represented as bell-shape curve with maximum activity at around 50 nM, changed biphasic mode through proteolysis thermolysin. Two distinct components were isolated from thermolytic fragments. One component, fragment mass...
Testicular microlithiasis was found in a 30-year-old infertile man. The literature is reviewed and the possible influence of testicular on male infertility discussed.