A5027119462- Food Security and Health in Diverse Populations
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Global Maternal and Child Health
- Diabetes Management and Research
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- COVID-19 and Mental Health
- Racial and Ethnic Identity Research
- COVID-19 and healthcare impacts
- IL-33, ST2, and ILC Pathways
- Ovarian function and disorders
- HIV, Drug Use, Sexual Risk
- Child Abuse and Trauma
- Wound Healing and Treatments
- HIV/AIDS Research and Interventions
- Maternal Mental Health During Pregnancy and Postpartum
- Hemoglobinopathies and Related Disorders
- Antimicrobial Peptides and Activities
- Maternal and Perinatal Health Interventions
- Diet, Metabolism, and Disease
- Adolescent Sexual and Reproductive Health
- Antibiotic Use and Resistance
University of Cambridge
2023-2024
National Institute of Environmental Health Sciences
2023-2024
National Institute for Health Research
2024
National Institutes of Health
2024
Occidental College
2023
Triangle
2023
University of Michigan
2020-2022
Janssen (United States)
2022
University of Florida Health
2020-2021
Cleveland Clinic
2021
Black patients are overrepresented in the number of COVID-19 infections, hospitalizations, and deaths US. Reasons for this disparity may be due to underlying comorbidities or sociodemographic factors that require further exploration.To systematically determine patient characteristics associated with racial/ethnic disparities outcomes.This retrospective cohort study used comparative groups tested treated at University Michigan from March 10, 2020, April 22, an outcome update through July 28,...
Structured Abstract Importance Blacks/African-Americans are overrepresented in the number of COVID-19 infections, hospitalizations and deaths. Reasons for this disparity have not been well-characterized but may be due to underlying comorbidities or sociodemographic factors. Objective To systematically determine patient characteristics associated with racial/ethnic disparities outcomes. Design A retrospective cohort study comparative control groups. Setting Patients tested at University...
Background: We performed a phenome-wide association study to identify pre-existing conditions related Coronavirus disease 2019 (COVID-19) prognosis across the medical phenome and how they vary by race. Methods: The is comprised of 53,853 patients who were tested/diagnosed for COVID-19 between 10 March 2 September 2020 at large academic center. Results: Pre-existing strongly associated with hospitalization renal failure, pulmonary heart disease, respiratory failure. Hematopoietic intensive...
Background and aim: Mendelian Randomization (MR) is a widely used tool to estimate causal effects using genetic variants as instrumental variables. MR limited cross-sectional summary statistics of different samples time points analyse time-varying effects. We aimed at longitudinal for an exposure in multivariable setting validating the effect estimates mean, slope within-individual variability. Simulation study: tested our approach various scenarios power type I error, depending on...
Acute diarrhoeal disease management often requires rehydration alone without antibiotics. However, non-indicated antibiotics are frequently ordered and this is an important driver of antimicrobial resistance. The mHealth Diarrhoea Management (mHDM) trial aimed to establish whether electronic decision support improves antibiotic guideline adherence in resource-limited settings. A cluster randomised controlled was done at ten district hospitals Bangladesh. Inclusion criteria were patients aged...
Polycystic ovary syndrome (PCOS) and its underlying features remain poorly understood. In this genetic proteomic study, we expand the number of loci from 19 to 29, identify 31 associated plasma proteins. Many risk-increasing were with later age at menopause, underscoring reproductive longevity related a larger functional ovarian reserve. Hormonal regulation in aetiology condition, through metabolic features, was emphasised. The analysis highlighted perturbations metabolically-related biology...
Laboratory-based respiratory polymerase chain reaction (PCR) panels are rarely used in outpatient pediatric practice due to prolonged turn-around times and cost of medical equipment. The BioFire FilmArray Respiratory Panel EZ (RP EZ) is a Clinical Laboratory Improvement Amendments-waived pathogen PCR panel which rapidly tests for 14 common organisms. aim this study was identify the distribution organisms seen clinics determine if utilization point-of-care test improved disease management,...
Previously, we demonstrated low-dose antithymocyte globulin (ATG) and granulocyte colony-stimulating factor (GCSF) immunotherapy preserved C-peptide for 2 years in a pilot study of patients with established type 1 diabetes (n = 25). Here, evaluated the long-term outcomes ATG/GCSF participants 5 available follow-up data 15). The primary end point was area under curve (AUC) during 2-h mixed-meal tolerance test. After years, there were no statistically significant differences AUC when comparing...
Introduction: Asthma is a chronic disease of the airways that impairs normal breathing. The etiology asthma complex and involves multiple factors, including environment genetics, especially distinct genetic architecture associated with ancestry. Compared to early-onset asthma, little known about predisposition late-onset asthma. We investigated race/ethnicity-specific relationship among variants within major histocompatibility (MHC) region in North Carolina-based multiracial cohort adults....
Building on nascent literature examining the health-related effects of vicarious structural racism, we examined indirect exposure to Flint Water Crisis (FWC) as a predictor birth outcomes in Michigan communities outside Flint, where residents were not directly exposed lead-contaminated water. Using linear regression models, analyzed records for all singleton live births from 2013 2016, excluding determine whether weight (BW), gestational age (GA), and size-for-gestational-age (SzGA)...
Abstract Spatial partitioning is a classic hypothesis to explain plant species coexistence, but evidence linking local environmental variation spatial sorting, demography and species' traits sparse. If co‐occurring performance optimized differently along gradients because of trait variation, then might facilitate coexistence. We used system four naturally Clarkia (Onagraceae) ask whether distribution patchiness corresponds in two variables that contribute hydrological variation. reciprocally...
Non-alcoholic steatohepatitis (NASH), which can lead to liver failure, requires biopsies follow and is difficult treat. Our goal was assess metabolic syndrome (MetS) severity as a predictor of treatment success marker response.We assessed data from the Pioglitazone, Vitamin E, or Placebo for NASH Study, in individuals with biopsy-confirmed were randomized receive pioglitazone, vitamin placebo 96 weeks. We associations sex-specific race/ethnicity-specific MetS Z-score (MetS-Z) at baseline 48...
The COVID-19 pandemic has caused morbidity and mortality, particularly among vulnerable populations. We aimed to assess social demographic characteristics associated with severity symptomatic participants during pregnancy.The International Registry of Coronavirus Exposure in Pregnancy is a multinational, longitudinal observational cohort study adult tested for SARS-CoV-2 or who received clinical diagnosis pregnancy (NCT04366986). Disease status mild, moderate, severe was determined based on...
Florida has the second highest number of newly diagnosed cases HIV in United States. Sociodemographic representation that is reflective population essential developing evidence based interventions to improve outcomes and reduce disparities. Understanding research trial participation, preferences for types research, fair compensation will further our understanding someone’s decision participate research. The purpose this analysis was identify differences prior trust, interests between people...
Genetic factors related to pregnancy-related traits are understudied, especially in ancestrally diverse cohorts. To assess maternal contributions hypertensive disorders of pregnancy (HDP, we performed a multi-ancestry genome-wide association study (GWAS) HDP data from the North Carolina-based Personalized Environment and Genes Study (PEGS) cohort with validation UK Biobank (UKBB). The GWAS revealed two loci associated at significance level. lead independent variants were rs114954125 on...
BACKGROUND: Elevated maternal serum sFLT1 (soluble fms-like tyrosine kinase 1) has a key role in the pathophysiology of preeclampsia. We sought to determine relationship between and fetal genome levels at 12, 20, 28, 36 weeks gestational age (wkGA). METHODS: studied prospective cohort nulliparous women (3968 mother-child pairs). related genotype adjusted Z score sFLT1:placental growth factor (PlGF) ratio each wkGA change 28 (Δ36-28). genetic variants from previous genome-wide association...
Abstract Background We perform a phenome-wide scan to identify pre-existing conditions related COVID-19 susceptibility and prognosis across the medical phenome how they vary by race. Methods The study is comprised of 53,853 patients who were tested/positive for between March 10 September 2, 2020 at large academic center. Results Pre-existing strongly associated with hospitalization renal failure, pulmonary heart disease , respiratory failure . Hematopoietic ICU admission/mortality mental...
Background: Acute diarrhoeal disease management often requires rehydration alone without antibiotics. However, antibiotics are frequently used inappropriately and this is an important driver of antimicrobial resistance. The mHDM trial was conducted to determine if electronic decision-support improves antibiotic guideline adherence in resource-limited settings.Methods: A cluster randomized controlled at ten district hospitals Bangladesh. Inclusion criteria were patients two-months age or...
Background Delivery by cesarean section (C-section) is associated with adverse short-term and long-term infant outcomes. Given that antibiotics during early life are prescribed for outcomes more likely among c-section deliveries, we hypothesized postnatal antibiotic exposure will be greater infants compared to vaginally delivered infants. Objective The aim of this paper was evaluate if mode delivery patterns systemic in children their first three years. Methods Pediatric electronic health...
Metabolic monitoring is important for children taking antipsychotic medication, given the risk increased BMI, impaired glucose metabolism, and hyperlipidemia. The purpose was to examine influence of provider specialty on receipt metabolic monitoring. Specifically, differences in recommended care when a child receives outpatient from primary (PCP), mental health with prescribing privileges, or both examined.Medicaid enrollment pharmacy claims data 2 states were used analyses. Providers...
Previously, we demonstrated low-dose anti-thymocyte globulin (ATG) and granulocyte colony stimulating factor (GCSF) immunotherapy preserved C-peptide for two years in a pilot study of subjects with established type 1 diabetes (n=25). Herein, evaluated the long-term outcomes ATG/GCSF participants five available follow-up data (n=15). The primary endpoint was area under curve (AUC) during two-hour mixed-meal tolerance test (MMTT). After years, there were no statistically significant...