A5101554295- Pancreatic function and diabetes
- Renal and Vascular Pathologies
- Cannabis and Cannabinoid Research
- Foot and Ankle Surgery
- Diabetes and associated disorders
- Transplantation: Methods and Outcomes
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Monoclonal and Polyclonal Antibodies Research
- Acute Kidney Injury Research
- Renal cell carcinoma treatment
- Metabolism, Diabetes, and Cancer
- Organ Donation and Transplantation
- Hematopoietic Stem Cell Transplantation
- Shoulder Injury and Treatment
- T-cell and B-cell Immunology
- Cardiac Ischemia and Reperfusion
- Bone and Joint Diseases
- Sports injuries and prevention
- Polyamine Metabolism and Applications
- Gastrointestinal Bleeding Diagnosis and Treatment
- Surgical Simulation and Training
Orthopedic Foot & Ankle Center
2023
Inserm
2023
Institut Pasteur de Lille
2023
Centre Hospitalier Universitaire de Lille
2023
Kent State University
2018-2023
Columbia University Irving Medical Center
2016-2023
Pacific Clinics
2022
NewYork–Presbyterian Hospital
1978-2019
New York Hospital Queens
2016-2019
Johns Hopkins University
2014
The purification and chemical properties of thymosin, obtained from bovine thymus tissue, are described. biological activity the thymic hormone has been assessed by a newly developed rosette assay, which permits measurement thymus-dependent lymphoid cells. Thymosin is associated with physico-chemically homogeneous protein molecular weight 12,600. hormonal evident in vitro incubation after injection into adult thymectomized mice, prolonging survival neonatally mice reconstitution their...
Diabetes results from an absolute or relative reduction in pancreatic beta cell mass (BCM) leading to insufficient insulin secretion and hyperglycemia. Measurement of secretory capacity is currently used as a surrogate measure BCM. However, serum concentrations provide imprecise index BCM, no reliable noninvasive BCM available. Type 2 vesicular monoamine transporters (VMAT2) are expressed human islet cells, well tissues the CNS. [11C]Dihydrotetrabenazine ([11C]DTBZ) binds specifically VMAT2...
Abstract The purpose of our study was to identify transcripts specific for tissue-restricted, membrane-associated proteins in human islets that, turn, might serve as markers healthy or diseased islet cell masses. Using oligonucleotide chips, we obtained gene expression profiles comparison with the exocrine pancreas, liver, and kidney tissue. As periislet presence type 1 interferon is associated development diabetes, profile treated ex vivo interferon-α2β (IFNα2β) also determined. A set genes...
Abstract A patient with classic clinical and biochemical features of tumor-induced osteomalacia (hypophosphatemia, phosphaturia, undetectable serum concentrations 1,25-dihydroxyvitamin D [1,25(OH)2D]) was studied before after resection a benign extraskeletal chondroma from the plantar surface foot. Presurgical laboratory evaluation notable for normal calcium, intact parathyroid hormone (PTH), hormone-related protein (PTHrP), osteocalcin, increased alkaline phosphatase activity, frankly...
Vitamin A palmitate was incorporated into a laboratory chow (150,000 IU/kg diet) and fed ad libitum to C3H/HeJ female mice inoculated with 1 × 106 C3HBA tumor cells, beginning the day of inoculation. Control same strain similarly were alone. did not affect incidence, but it decrease growth rate for first 19 days, after which rates independent treatment. A-treated survived significantly longer times than control mice.
<b><i>Introduction:</i></b> Medicinal cannabis is prescribed in Australia for patients with chronic refractory pain conditions. However, measures of safety and effectiveness different cannabinoids are lacking. We designed an observational study to capture effectiveness, adverse events (AEs), health-related quality life (HRQoL) oral medicinal formulation at Cannabis Access Clinics through the Observational (CACOS). <b><i>Objectives:</i></b>...
Gene expression variation is shaped by both genetic and environmental effects, yet these two factors are rarely considered together in the context of adaptive evolution. We studied influences on gene regulatory evolution ...Changes thought to play a major role While it known that highly sensitive environment, very few studies have determined influence effects ...
Abstract Despite different embryological origins, islet β-cells and neurons share the expression of many genes display multiple functional similarities. One shared gene product, vesicular monoamine transporter type 2 (VMAT2, also known as SLC18A2), is highly expressed in human relative to other cells endocrine exocrine pancreas. Recent reports suggest that dopamine an important paracrine and/or autocrine regulator insulin release by β-cells. Given role VMAT2 economy monoamines such dopamine,...
THE in vivo angiographic study of smaller blood vessels to various organs under both normal and pathological conditions has been the subject much recent work interest. Utilizing a technic photographic magnification angiography (1), we have studied effects large doses radiation (1,500 or 3,000 R single dose) upon short segments canine bowel. The presentation angiograms obtained with this technic, including correlation findings vitro injection studies irradiated bowel gross microscopic...
The effect of thymosin on in vitro reactivity peripheral lymphocytes to phyto-hemagglutinin, concanavalin A, and the formation spontaneous E-rosettes 54 patients with metastatic carcinomas has been studied. Thymosin increased lymphocyte responses PHA Con A only 10 patients, predominant seen A. Twenty showed depressed baseline levels which were normal or subnormal after incubation thymosin. No distinct correlation was noted between clinical stage disease ability form E-rosettes. Although...
In continuation of our studies using UV-B-irradiated DST and donor leukocyte (DL) recipient pretreatment to induce specific unresponsiveness organ allografts, we have examined the relative contributions splenic lymphocyte populations T subsets in induction immunologic unresponsiveness. Our data show that enriched MHC class II-positive B lymphocytes W3/25+ cell subset obtained from leukocytes immunoadsorbent columns conjunction with mAbs led indefinite graft survival (>100 days) Lewis-to-ACI...
Objective We sought to describe a technique for ultra-low-contrast angiography (ULCA) in patients with advanced chronic kidney disease (CKD) and previous coronary artery bypass surgery (CABG). Background Patients CKD CABG are at high risk of developing contrast-induced nephropathy (CIN) because the additional contrast often required identify grafts. Apart from hydration, reduced administration is only established method minimize CIN. methods Ten underwent ULCA, whereby an intracoronary...