A5071413591- Metallurgy and Cultural Artifacts
- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Emotions and Moral Behavior
- Liver Disease Diagnosis and Treatment
- Psychology of Moral and Emotional Judgment
- Endoplasmic Reticulum Stress and Disease
- Osteoarthritis Treatment and Mechanisms
- Laser Applications in Dentistry and Medicine
- Lipid metabolism and biosynthesis
- Burn Injury Management and Outcomes
- Archaeology and ancient environmental studies
- Technology Use by Older Adults
- Metabolism, Diabetes, and Cancer
- Fiber-reinforced polymer composites
- Gastrointestinal Tumor Research and Treatment
- Cultural Differences and Values
- Death Anxiety and Social Exclusion
- Probiotics and Fermented Foods
- Frailty in Older Adults
- Pancreatitis Pathology and Treatment
- Cystic Fibrosis Research Advances
National Clinical Research Center for Digestive Diseases
2022-2025
Capital Medical University
2018-2025
Beijing Friendship Hospital
2021-2025
Nanjing Normal University
2024
Scripps Research Institute
2021-2024
California Institute for Biomedical Research
2021-2024
Guangzhou Medical University
2023
Hunan Normal University
2022-2023
Guangzhou Blood Center
2023
Shanghai Normal University
2023
Abstract:
To explore the composition of intestinal microbiota in ulcerative colitis (UC) patients and to identify differences between with active disease those remission.Between September 2020 June 2021, we enrolled into our study, collected stool samples from, UC or remission healthy control subjects. The diagnosis was based on clinical, endoscopic, radiological, histological findings. determined by sequencing 16S rRNA V3-V4 region bioinformatic methods. functional predicted using PICRUSt 2...
X842 is a new type of gastric acid-suppressing agent with rapid onset action and long duration effect. We aim to investigate the efficacy safety different doses vs lansoprazole in treatment patients erosive esophagitis (EE). This phase 2 study included 90 EE (Los Angeles grades A-D) who were randomized (1:1:1) receive oral low-dose (50 mg/d, n = 31), high-dose (100 or (30 30) for 4 weeks. The main end point was healing rate, which proportion achieved endoscopic after weeks treatment. For...
Hyperhomocysteinaemia [HHcy] is a common phenomenon observed in patients with inflammatory bowel disease [IBD]. Homocysteine pro-inflammatory molecule and has been identified as risk factor for cardiovascular cerebral diseases. Whether HHcy contributes to the chronic inflammation of colon IBD rarely explored. The aim this study was investigate effect on dextran sulphate sodium [DSS]-induced colitis. Wistar rats were randomly divided into eight groups: [1] Control; [2] HHcy; [3] p38...
Periodontal ligament stem cell- (PDLSC-) mediated periodontal tissue regeneration has recently been proposed for the new therapeutic method to regenerate lost alveolar bone and ligament. It was reported that both autogenic allogeneic PDLSCs could reconstruct damaged tissues but effects were not consistent. The effective methods improve properties of should be further considered. In this study, we investigated if D-mannose affect immunomodulatory hPDLSCs. After being pretreated with...
The present study was designed to investigate the effects of microRNA-21 (miR-21) on orthodontic tooth movement.The movement model established in C57BL/6 and miR-21-/- mice with or without implantation activated T cells. Histological histomorphometrical analyses were performed by hematoxylin-eosin staining. Tartrate-resistant acid phosphate staining used analyze osteoclast numbers during movement. Enzyme-linked immunosorbent assay, reverse transcription polymerase chain reaction,...
Inflammation of chondrocytes plays a critical role in the occurrence and development osteoarthritis (OA). Recent evidence indicated exosomes derived from mesenchymal stem cells (MSCs-Exos) exhibit excellent anti-inflammatory ability many troublesome inflammatory diseases including OA. In present study, we aimed to explore human umbilical cord-derived MSCs-Exos (hUC-MSCs-Exos) treating inflammation its related mechanisms. Ultracentrifugation was applied isolate hUC-MSCs-Exos culture...
This study explores the willingness of older adults to use smartphones and improve their digital skills encourages nursing actively participate in bridging divide.Subject analysis was used conduct qualitative research, 23 were interviewed.We identified four themes: (1) current situation smartphone use; (2) dilemma (3) social support for skills; (4) learn skills. Older China are willing accept simple operations, peer learning may be an effective way skills.Community is necessary develop with...
PERK (EIF2AK3) is an ER-resident eIF2α kinase required for memory flexibility and metabotropic glutamate receptor-dependent long-term depression, processes known to be dependent on new protein synthesis. Here we investigated PERK's role in working memory, a cognitive ability that independent of synthesis, but instead cellular Ca2+ dynamics. We found impaired forebrain-specific Perk knockout pharmacologically PERK-inhibited mice. Moreover, inhibition wild-type mice mimics the fear extinction...
Colorectal neoplasms (CRN) include colorectal cancer (CRC) and adenoma (CRA). The relationship between CRN triglyceride-glucose (TyG) index or atherogenic of plasma (AIP) is unclear. This study aims to investigate the roles TyG AIP in predicting people without cardiovascular disease (CVD). 2409 patients CVD underwent colonoscopy were enrolled. Clinical information relevant laboratory test results these collected recorded. According endoscopic pathological results, all participants divided...
Background Natural killer T (NKT) cells share phenotypic and functional properties with both conventional natural cells. These might have an important role in the pathogenesis of ulcerative colitis (UC). The interaction chemokine ligand 25 (CCL25) receptor 9 (CCR9) is involved gut-specific migration leukocytes induces regulatory (Tregs) to migrate intestine chronic ileitis. Methodology/Findings In UC patients, NKT CD161, CCL25, CCR9 expression levels were evaluated by qRT-PCR. A murine model...
Wound healing can be divided into different phases, and timely initiation cessation of these stages is key to successful wound healing; otherwise, scar tissue forms in the wounded area. Connexins (Cxs) were confirmed influence formation, Cx43, an indispensable member Cx family, was shown involved this process. Our study investigated regulatory role Cx43 formation possible cell signalling pathways. We established oral mucosa skin models C57BL/6J mice. RT-PCR, western blotting,...
The proinflammatory effects of IL12p40 had been documented in the literature, and anti-IL12p40 treatment proved to be effective therapy Crohn disease (CD) a phase 2b clinical trial. However, precise role pathogenesis inflammatory bowel (IBD) was still poorly understood. In this study, we investigated expressions its receptor interleukin-12 β 1 both locally systemically IBD cases healthy controls, contribution pathogenesis. We found that expression elevated at messenger RNA protein levels...
To evaluate the effect of 3-dimensional (3D) imaging device on polyp and adenoma detection during colonoscopy.In a single-blind, randomized controlled trial, participants aged 18-70 years who underwent diagnostic or screening colonoscopy were consecutively enrolled between August 2019 May 2022. Each participant was in 1:1 ratio to undergo either 2-dimensional (2D-3D) 3D-2D through computer-generated random numbers. Primary outcome included rate (PDR) (ADR), defined as proportion individuals...
Unfolded protein response (UPR) is a stress that specific to the endoplasmic reticulum (ER). UPR activated upon accumulation of unfolded (or misfolded) proteins in ER's lumen restore folding capacity by increasing synthesis chaperones. In addition, also enhances degradation and reduces global alleviate additional ER. Herein, we describe cell-based ultra-high throughput screening (uHTS) campaign identifies small molecule can modulate ER cellular vivo disease models. Using asialoglycoprotein...
The crucial role that Xinjiang played in cultural communication across the Eurasian steppe prehistory is evidenced by large number of copper-based objects represent early metallurgical technologies found this region. Our research adds new chemical and isotopic analyses 44 dated to Iron Age Ili Xinjiang, western China. As noted a publications, tin bronze arsenic copper/bronze were dominant alloying types during second first millennium BC, whereas some specific such as cauldrons are often made...
Objectives Although colonoscopy remains the gold standard for determining bowel diseases, it's invasive and expensive. New non-invasive diagnostic methods are urgently needed as an initial screening modality. We aimed to investigate value of fecal calprotectin (FC) immunochemical test (FIT) in differentiation significant non- diseases.Methods In this prospective study, consecutive individuals were included if they underwent symptoms lower gastrointestinal (GI) tract, positive occult blood...
Abstract Dysfunctional liver regeneration following surgical resection remains a major cause of postoperative mortality and has no therapeutic options. Without targeted therapies, the current treatment paradigm relies on supportive therapy until homeostasis can be achieved. Pharmacologic acceleration represents an alternative avenue. Therefore, we aimed to generate small molecule inhibitor that could accelerate with emphasis diseased models, which represent significant portion patients who...
In second language studies, motivation and anxiety have always been the focus of scholars at home abroad. This study conducted a questionnaire survey on over 120 Chinese IELTS candidates selected 5 participants for case interviews. Relevant analysis was results survey, interview data also summarized, aiming exploring relationship between motivation, anxiety, academic performance in acquisition represented by exam. The research has shown that there is significant positive correlation scores...
Particle-enhanced turbidimetric immunoassay (PETIA) is a new measurement procedure for detecting fecal calprotectin (FC). We aimed to investigate the accuracy and clinical performance of PETIA FC. assessed FC measurements through concordance analysis, Passing-Bablok regression Bland-Altman using enzyme-linked immunosorbent assay (ELISA) as reference. To evaluate PETIA, levels individuals with significant non-significant bowel diseases were compared. The receiver operating characteristic...