A5080204073- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Parathyroid Disorders and Treatments
- Nanoparticle-Based Drug Delivery
- Dialysis and Renal Disease Management
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Metabolomics and Mass Spectrometry Studies
- Ultrasound Imaging and Elastography
- Proteoglycans and glycosaminoglycans research
- Advanced Fluorescence Microscopy Techniques
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- ECG Monitoring and Analysis
- Erythropoietin and Anemia Treatment
- Atherosclerosis and Cardiovascular Diseases
- Glycosylation and Glycoproteins Research
- Agriculture and Biological Studies
- Acute Kidney Injury Research
- Catalysis for Biomass Conversion
- Lipid metabolism and disorders
- Thyroid and Parathyroid Surgery
- Advanced Cellulose Research Studies
- Chronic Kidney Disease and Diabetes
- Effects of Radiation Exposure
RWTH Aachen University
2012-2024
Universitätsklinikum Aachen
2016-2023
Soochow University
2023
Hunan University of Traditional Chinese Medicine
2021-2022
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2022
South China Agricultural University
2021
First Affiliated Hospital of Xi'an Jiaotong University
2021
Changsha University of Science and Technology
2020
University of Twente
2013-2017
Maastricht University
2013-2017
The crosstalk of the heart with distant organs such as lung, liver, gut, and kidney has been intensively approached lately. is involved in (1) production systemic relevant products, renin, part most essential vasoregulatory system human body, (2) clearance metabolites organ effects. Metabolic residue accumulation during dysfunction known to determine cardiovascular pathologies endothelial activation/dysfunction, atherosclerosis, cardiomyocyte apoptosis, cardiac fibrosis, vascular valvular...
Background— The aim of this study was to determine the role chemokine receptor CXCR7 in atherosclerosis and vascular remodeling. is alternative CXCL12, which regulates stem cell–mediated repair limits via its receptor, CXCR4. Methods Results— Wire-induced injury carotid artery performed mice with a ubiquitous, conditional deletion treated synthetic ligand CCX771. effect CCX771 treatment on studied apolipoprotein E–deficient ( Apoe −/− ) fed high-fat diet for 12 weeks. Lipoprotein fractions...
The retention and cellular internalization of drug delivery systems theranostics for cancer therapy can be improved by targeting molecules. Since an increased uptake riboflavin was reported various cancers, its derivatives may promising binding moieties to trigger via the transporters (RFVT) 1, 2, 3. Riboflavin is a vitamin with pivotal role in energy metabolism indispensable growth. In previous preclinical studies on mice, we showed target-specific accumulation riboflavin-functionalized...
Viral nanoparticles (VNPs) based on plant viruses such as Cowpea mosaic virus (CPMV) can be used for a broad range of biomedical applications because they present robust scaffold that allows functionalization by chemical conjugation and genetic modification, thereby offering an efficient drug delivery platform target specific cells tissues. VNPs CPMV show natural affinity to cells; however, cellular uptake is inefficient. Here we modification the surface with highly reactive, UV-traceable...
Abstract Background It is important to generate biofuels and society must be weaned from its dependency on fossil fuels. In order produce biofuels, lignocellulose pretreated the resulting cellulose hydrolyzed by cellulases such as cellobiohydrolases (CBH) endoglucanases (EG). Until now, biofuel industry has usually applied impractical celluloses screen for capable of degrading naturally occurring, insoluble cellulose. This study investigates how these adsorb hydrolyze α-cellulose −...
Novel polymeric cell adhesion inhibitors were developed in which the selectin tetrasaccharide sialyl-LewisX (SLeX ) is multivalently presented on a biocompatible poly(2-hydroxypropyl)methacrylamide (PHPMA) backbone either alone (P1) or combination with O-sulfated tyramine side chains (P2). For comparison, corresponding glycomimetics prepared crucial "single carbohydrate" substructures fucose, galactose, and sialic acid randomly linked to PHPMA (P3 P4 (O-sulfated tyramine)). All polymers have...
Hemerocallis citrina Baroni (HC) is an edible plant in Asia, and it has been traditionally used for sleep-improvement. However, the bioactive components mechanism of HC sleep-improvement are still unclear. In this study, effect hydroalcoholic extract was investigated based on a caffeine-induced insomnia model Drosophila melanogaster (D. melanogaster), ultrahigh-performance liquid chromatography coupled with electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry...
The purposes of this study were the development and preclinical evaluation clinically translatable E-selectin-specific ultrasound contrast agents based on a peptide ligand with recognition sequence IELLQAR.The was synthesized through solid phase synthesis covalently attached to poly n-butylcyanoacrylate-stabilized microbubbles an air core. Quantification microbubble surface coverage peptides performed flow cytometry. Targeted adhesion peptide-coated investigated in vitro using parallel plate...
The junctional adhesion molecule A (JAM-A) is physiologically located in interendothelial tight junctions and focally redistributes to the luminal surface of blood vessels under abnormal shear flow conditions accompanying atherosclerotic lesion development. Therefore, JAM-A was evaluated as a target for molecularly targeted ultrasound imaging transient endothelial dysfunction acute variations.Flow-dependent induced apolipoprotein E-deficient mice (n=43) by carotid partial ligation....
Objective— Cardiovascular interventions induce damage to the vessel wall making antithrombotic therapy inevitable until complete endothelial recovery. Without a method accurately determine status, many patients undergo prolonged anticoagulation therapy, denying them any invasive medical procedures, such as surgical operations and dental interventions. Therefore, we aim introduce molecular ultrasound imaging of vascular cell adhesion molecule (VCAM)-1 using targeted poly- n...
The ability to image incipient atherosclerosis is based on the early events taking place at endothelial level. We hypothesized that expression of intercellular adhesion molecule-1 even in vessels with high flow rates can be imaged molecular level using 2 complementary imaging techniques: 2-photon laser scanning microscopy and contrast-enhanced ultrasound.Using ultrasound, molecule-1-targeted rhodamine-loaded microbubbles were shown specifically bound tumor necrosis factor-α-stimulated human...
Aim: To enable multimodal in vivo and ex optical imaging of the biodistribution tumor accumulation core-crosslinked polymeric micelles (CCPMs). Materials & methods: mPEG-b-p(HPMAm-Lac)-based micelles, via cystamine covalently labeled with two different fluorophores (Dy-676/488), were synthesized. The CCPMs intravenously injected into CT26 tumor-bearing mice. Results: Upon intravenous injection, accumulated tumors reasonably efficiently, values reaching approximately 4%ID at 24 h. Ex...
Houttuynia cordata Thunb. is a traditional Chinese herb widely used mainly because of the pharmacological effects related to heat clearance and detoxification. Emerging clinical evidence indicates that efficacy on RILI upstanding. Nevertheless, its underlying therapeutic mechanism remains unclear warrants further elucidation.The major active components corresponding targets were retrieved from medicine system pharmacology database (TCMSP) literature review. The GeneCards database. Common...
This study aimed to develop an exosome-coated polydatin (PD) nanoparticles (exo-PD) for improving the water solubility and bioavailability of explore its salutary effects on intestinal radiation injury. Exosomes (exo) were extracted from medium human amniotic fluid stem cells (hAFSc). Mice divided into control group, irradiation (IR) irradiation+PD (IR+PD) irradiation+exo (IR+exo) group irradiation+exo-PD (IR+exo-PD) group. The results characterization protein markers, particle size,...