A5029577907- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Innovations in Medical Education
- Thyroid Disorders and Treatments
- Muscle metabolism and nutrition
- Pituitary Gland Disorders and Treatments
- Biochemical effects in animals
- Neuroendocrine Tumor Research Advances
- Electrolyte and hormonal disorders
- Neuropeptides and Animal Physiology
- Syphilis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Clinical Reasoning and Diagnostic Skills
- Neuroblastoma Research and Treatments
- Ethics in Clinical Research
- Hemoglobinopathies and Related Disorders
- Pharmaceutical Practices and Patient Outcomes
- Tuberculosis Research and Epidemiology
- Artificial Intelligence in Healthcare and Education
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- Iron Metabolism and Disorders
- Gestational Trophoblastic Disease Studies
- Menopause: Health Impacts and Treatments
Imperial College London
2013-2024
University of Cyberjaya
2024
Aga Khan University Hospital
2024
Imperial College Healthcare NHS Trust
2010-2021
Hammersmith Hospital
2011-2017
Assistance Publique – Hôpitaux de Paris
2014
Bicêtre Hospital
2014
Barts Health NHS Trust
2008-2013
Charing Cross Hospital
2010
St Mary's Hospital
2010
High-protein diets (HPDs) are associated with greater satiety and weight loss than rich in other macronutrients. The exact mechanisms by which HPDs exert their effects unclear. However, evidence suggests that the sensing of amino acids produced as a result protein digestion may have role appetite regulation satiety. We investigated l-phenylalanine (L-Phe) on food intake glucose homeostasis rodents.We aromatic amino-acid calcium-sensing receptor (CaSR) agonist release gastrointestinal (GI)...
Introduction Patients with diabetes mellitus admitted to hospital COVID-19 have poorer outcomes. However, the drivers of outcomes are not fully elucidated. We performed detailed characterization patients determine clinical and biochemical factors that may be Research design methods This is a retrospective cohort study 889 consecutive inpatients diagnosed between March 9 April 22, 2020 in large London National Health Service Trust. Unbiased multivariate logistic regression analysis was...
Abstract Aim Increased body iron is associated with insulin resistance. Hepcidin the key hormone that negatively regulates homeostasis. We hypothesized individuals resistance have inadequate hepcidin levels for their load. Methods Serum concentrations of active form (hepcidin‐25) and hepcidin:ferritin ratio were evaluated in participants Type 2 diabetes ( n = 33, control subjects matched age, gender BMI , 33) polycystic ovary syndrome 27, age 16). To investigate whether any changes observed...
Obesity is a major public health issue worldwide. Current pharmacological treatments are largely unsuccessful. Determining the complex pathways that regulate food intake may aid development of new treatments. The hypothalamic-pituitary-thyroid (HPT) axis has well-known effects on energy expenditure, but its role in regulation less well characterised. Evidence suggests HPT can directly influence intake. Thyroid dysfunction have clinically significant consequences appetite and body weight....
To compare student performance, examiner perceptions and cost of GPT-assisted (generative pretrained transformer-assisted) clinical professional skills assessment (CPSAs) items against created using standard methods.
To investigate the anorectic effect of L-arginine (L-Arg) in rodents.We investigated effects L-Arg on food intake, and role gut hormones glucagon-like peptide-1 (GLP-1) peptide YY (PYY), G-protein-coupled receptor family C group 6 member A (GPRC6A) vagus nerve mediating these rodents.Oral gavage reduced intake rodents, chronically cumulative diet-induced obese mice. Lack GPRC6A mice subdiaphragmatic vagal deafferentation rats did not influence effects. stimulated GLP-1 PYY release vitro...
High-protein diets promote weight loss and subsequent maintenance, but are difficult to adhere to. The mechanisms by which protein exerts these effects remain unclear. However, the amino acids produced digestion may have a role in driving protein-induced satiety. We tested of range on food intake rodents identified l-cysteine as most anorexigenic. Using we further studied effect intake, behaviour energy expenditure. proceeded investigate its neuronal activation hypothalamus brainstem before...
ABSTRACT This is a substudy of the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) Comparison Nevirapine and Efavirenz for Treatment HIV-TB Co-infected Patients (ANRS 12146-CARINEMO) trial, which assessed pharmacokinetics rifampin or isoniazid with without coadministration nonnucleoside reverse transcriptase inhibitor-based HIV antiretroviral therapy in HIV-tuberculosis-coinfected patients Mozambique. Thirty-eight on antituberculosis based participated (57.9%...
Objective The satiating effect of protein compared with other nutrients has been well described and is thought to be mediated, in part, by gut hormone release. Previously, it shown that oral L‐arginine acts as a GLP‐1 secretagogue both vitro vivo rodents. Here, the on release humans was investigated. Methods hypothesis tested two separate studies. first study assessed tolerability healthy human subjects. second following an ad libitum meal. Subjects were given L‐arginine, glycine (control...
<h3>Background</h3> Fast and reliable detection of <i>Mycobacterium tuberculosis</i> complex (MTBC) drug resistance is crucial in establishing effective treatment enforcing timely public health measures. <h3>Methods</h3> The authors analysed the performance a national UK molecular diagnostic service over decade, based on use line probe assay (Innolipa, LiPA) compared with conventional liquid solid cultures rapid identification culture-based testing. <h3>Findings</h3> Data were available for...
Abstract Aim To investigate the effects of L‐phenylalanine on gastroenteropancreatic hormone release, glucose levels, subjective appetite and energy intake in humans, to determine whether these were stereoisomer‐specific by comparing them with D‐phenylalanine. Materials methods A dose‐finding, non‐randomized, unblinded, crossover study was conducted during October–December 2017 at NIHR Imperial Clinical Research Facility five participants, which tolerability escalating doses oral assessed...
ABSTRACT Patients with diabetes mellitus admitted to hospital COVID-19 caused by infection the novel coronavirus (SARS-CoV-2) have poorer outcomes. However, drivers for this are not fully elucidated. We performed a retrospective cohort study, including detailed pre-hospital and presenting clinical biochemical factors of 889 patients diagnosed in three constituent hospitals large London NHS Trust. 62% severe were non-White ethnic backgrounds prevalence was 38%. 323 (36%) met primary outcome...
Abstract Summary This pilot audit explored how bone health is assessed patients with diabetes in diverse centres across Asia. Only 343 of 1092 (31%) audited had a assessment, 27% whom were diagnosed osteoporosis. Quality improvement strategies are needed to address gaps patient care this area. Purpose The Asia Pacific Consortium on Osteoporosis (APCO) Framework outlines clinical standards for assessing and managing A evaluated adherence standard 4, which states that should be conditions...
<h3>Objectives:</h3> The number of cases infectious syphilis is increasing rapidly across England and Wales. Concern has been expressed about diagnostic delay its potential impact on patient care. A standard operating procedure for the serological diagnosis recently developed by Health Protection Agency. This study aimed to audit clinical laboratory practice in Wales against this standard. <h3>Methods:</h3> All microbiology departments, genitourinary medicine (GUM) clinics antenatal were...
Pulmonary arteriovenous malformations (PAVMs) generate a right-to-left shunt. Impaired gas exchange results in hypoxaemia and impaired CO2 clearance. Most patients compensate effectively but some are dyspneic, these rarely the most hypoxaemic.To test degrees of concurrent pathology influencing exercise capacity.Replicate, sequential single centre, prospective studies.Cardiopulmonary tests (CPETs) were performed 26 with PAVMs, including individuals without known airflow obstruction. To...
Within the last few decades, an increasing lifespan and average menopausal age has resulted in a higher proportion of patients with type 2 diabetes (T2DM).1 Quality life is known to improve good glycaemic control yet barriers such as emotional distress weight gain are linked its deterioration. It also recognised that physiological hormonal changes sex hormones impede control.2 One most pervasive during menopause gain, specifically abdominal fat accumulation enlarged waist-to-hip ratio.3...
Medication errors cause preventable patient harm with annual costs of USD$42 billion globally. In England, 237 million occur annually, accounting for 1700 deaths, trainee doctors being responsible the highest proportion errors. The UK introduced national Prescribing Safety Assessment (PSA) in 2013 to ensure prescribing competency. Imperial College School Medicine (ICSM) sought increase learning opportunities and reduce through a monthly Practice Questions (PPQs) programme. PSA scores from...
This study aims to evaluate the transformational leadership level of Assistant Medical Officer Supervisors at Selangor State Specialist Hospital. Supervisor is very important for Officers, therefore an appropriate approach required meet needs organization. uses a cross-sectional survey method involving 304 respondents. Data collection was done using Multifactor Leadership Questionnaire (MLQ) Instrument which measures four dimensions leadership: ideal influence, inspirational motivation,...