A5102901543- Diabetes Treatment and Management
- Plant Pathogens and Fungal Diseases
- Eating Disorders and Behaviors
- Genetic Associations and Epidemiology
- Mycorrhizal Fungi and Plant Interactions
- Epilepsy research and treatment
- Antibiotic Use and Resistance
- Forensic Entomology and Diptera Studies
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Enterobacteriaceae and Cronobacter Research
- Monoclonal and Polyclonal Antibodies Research
- Parasitic infections in humans and animals
- Blood groups and transfusion
- Insects and Parasite Interactions
- Cancer-related molecular mechanisms research
- Gastrointestinal motility and disorders
- Glycogen Storage Diseases and Myoclonus
- Antifungal resistance and susceptibility
- Cardiac electrophysiology and arrhythmias
- Genetic Syndromes and Imprinting
- Genetics and Neurodevelopmental Disorders
- Yeasts and Rust Fungi Studies
- Bacterial biofilms and quorum sensing
- interferon and immune responses
Children's Hospital of Philadelphia
2015-2025
University of Louisville
2010-2022
Novo Nordisk (United States)
2019
University of Louisville Hospital
2010
American Medical Group Association
2000
In addition to HLA genetic incompatibility, non-HLA difference between donor and recipients of transplantation leading allograft rejection are now becoming evident. We aimed create a unique genome-wide platform facilitate genomic research studies in transplant-related studies. designed genotyping tool based on the most recent human reference datasets, included customization for known potentially relevant metabolic pharmacological loci transplantation. describe here design implementation...
Abstract Background Postural orthostatic tachycardia syndrome (POTS) is a complex disorder with serious health consequences, while its etiology remains largely elusive. Objective The purpose of this study was to investigate the genetic landscape POTS using genomic approaches in unique pediatric cohort. Methods We conducted combined genome wide genotyping and whole exome sequencing (WES) systemically examine molecular mechanisms pathogenesis. patients were genotyped as two independent...
ABSTRACT This study compared the BD GeneOhm methicillin-resistant Staphylococcus aureus (MRSA) real-time PCR assay to culture by use of BBL CHROMagar MRSA for detection in 627 nasal surveillance specimens collected from intensive care unit (ICU) patients. The had a sensitivity, specificity, positive predictive value, and negative value 100%, 96.7%, 70.3%, respectively. Nine 19 false-positive grew methicillin-susceptible S. (MSSA) broth enrichment culture, which two demonstrated evidence mec...
We report three cases of infection due to the Gram-negative rod Ignatzschineria (Schineria) indica involving bacteremia and urinary tract. Two were clearly associated with maggot infestation, third could conceivably have had unrecognized infestation believe these be first I. infections reported in association myiasis.
Abstract We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using stringently defined phenotype. Analysis phenotypic variability led to the identification specific genetic risk factor that approached significance (rs929626 in EBF1 (Early B-Cell Factor 1); P = 2.04 × 10 −7 ; OR 0.7; 95% confidence interval (CI) 0.61–0.8) with independent replication ( 0.04), suggesting variant-mediated dysregulation leptin signaling may play role AN. Multiple SNPs LD variant support...
OBJECTIVE: To use pharmacy and laboratory data to assess diabetes care within a medical group between groups determine dispensing patterns the extent which providers change therapy based on HbA1c results. RESEARCH DESIGN AND METHODS: Participating submitted 1 year of for continuously enrolled patients. Required included date birth, all diabetes-specific prescriptions (oral hypoglycemic agents insulin), prescription, National Drug Code, values, lower upper normal limits, testing. RESULTS: Few...
A wide range of clinical findings have been associated with mutations in Syntaxin Binding Protein 1 ( STXBP1 ), including multiple forms epilepsy, nonsyndromic intellectual disability, and movement disorders. recently mitochondrial pathology, although it remains unclear if this phenotype is a part the core feature for gene disorder. We report 7-year-old boy who presented diagnostic evaluation intractable episodic ataxia, resting tremor, speech regression following period apparently normal...
Up to 40% of patients with epilepsy become drug resistant (DRE). Genetic factors are likely play a role. While efforts have focused on the transporter and target hypotheses, neither them fully explains pan-pharmacoresistance seen in DRE.In this study, we developed used phenotyping algorithm for identification DRE, responders, epilepsy-free controls that were sequenced using gene panel by Pharmacogenomics Research Network (PGRN), which includes 82 genes involved response. We tested hypothesis...
In contrast to a robust literature on known pathogenic fungi such as Cryptococcus and Aspergillus species that cause pulmonary infections, reports of the uncommon genus Sporopachydermia causing infections are very limited. We present first case report describing fungus, lactativora likely pneumonia in patient with history polysubstance abuse injection drug use (IDU). The recovered following antifungal treatment. organism was from blood culture, 3 days post collection. Although CHROMagar...
Onset® 3 (eine 18-wöchige, randomisierte, kontrollierte Phase-3-Studie) zeigte, dass eine Basal-Bolus-Therapie (BBT) mit schnell wirksamem Insulin aspart (Faster aspart) bei der Blutzuckerkontrolle einer alleinigen Basaltherapie (BOT) Typ 2 Diabetes überlegen ist. In dieser Post-hoc-Auswertung wurde die Aussagekraft des PPG-Anstiegs, nächtlichen Veränderung Blutzuckers und HbA1c zu Baseline für Vorhersage Nutzens Bolusinsulin-Intensivierung untersucht.
Abstract As part of our laboratory testing utilization at University Louisville Hospital (ULH), any send-out test ≥$500 must be assessed by the clinical chemistry fellow or pathology resident for necessity and as a way to provide consultation ordering physician on appropriate utilization. In 2018, we noticed prominent increase in volume panels autoimmune encephalopathy (AE) related disorders being ordered. This was met with considerable cost hospital, lack consensus which should ordered,...
Introduction: Patients with a history of splenectomy have higher prevalence infections encapsulated organisms due to decreased phagocytic activity and humoral response. One such rare organism is Raoultella ornithinolytica, Gram-negative bacillus commonly found in the aquatic environment. Here we present case this bacterium causing liver abscess. Case Description/Methods: A 72-year-old female hypertension, hyperlipidemia, (secondary abdominal trauma) presented after being down. She complained...