A5101524649- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Image Processing Techniques and Applications
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Urinary and Genital Oncology Studies
- Endometrial and Cervical Cancer Treatments
- Gastrointestinal disorders and treatments
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Hepatitis Viruses Studies and Epidemiology
- Cell Image Analysis Techniques
- Bladder and Urothelial Cancer Treatments
- Multiple Myeloma Research and Treatments
- Chemokine receptors and signaling
- Advanced Glycation End Products research
Capital Medical University
2011-2024
Beijing YouAn Hospital
2011-2024
Capital University
2024
Beijing Fengtai Hospital
2023
Beijing Chao-Yang Hospital
2023
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2022
East Carolina University
2014-2015
CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) play critical roles in controlling the processes of tumors, infections, autoimmunity and graft rejection. Immunosuppressive drug rapamycin (RPM), targeting on key cellular metabolism molecule mTOR, is currently used clinics to treat patients with allo-grafts, autoimmune diseases tumors. However, effect RPM MDSCs has not been studied. significantly decreases cell number immunosuppressive ability T Ly6C(high) monocytic (M-MDSCs) both...
Administration of autologous invariant natural killer T (iNKT) cells was safe and well-tolerated in patients with hepatocellular carcinoma (Barcelona Clinic Liver Cancer stage B/C). Expanded iNKT produced T-helper 1-like responses possible antitumor activity. No severe adverse events were observed any the enrolled patients, including one patient who received 1010 vitro-expanded as a single infusion.Invariant co-express T-cell antigen receptor (NK) cell receptors. Invariant exhibit activity,...
Invariant NKT cells (iNKT) are CD1d-restricted T with the capacity of antitumor immunity. The safety autologous iNKT cell treatment in hepatocellular carcinoma (HCC) has been verified. This study aimed to investigate its efficacy advanced HCC after transarterial chemoembolization (TACE) failure.This open-label, randomized, controlled, trial enrolled 60 patients unresectable TACE failure at three centers. Transarterial embolization (TAE) was used instead protect function. Patients were...
NY-ESO-1 belongs to the cancer testis antigens (CTA) family, and is identified in a variety of tumors. Certain studies have demonstrated that predicts tumor recurrence treatment response. No reports are currently available regarding correlation between hepatocellular carcinoma (HCC) following surgery. The purpose present study was evaluate association relapse HCC explore possible mechanisms for this correlation. A total 120 patients were analyzed expression by immunohistochemistry (IHC)....
Accurate classification of malignant cells from benign ones can significantly enhance cancer diagnosis and prognosis by detection circulating tumor (CTCs). We have investigated two approaches quantitative morphology polarization diffraction imaging on prostate cell types to evaluate their feasibility as single-cell assay methods toward CTC after enrichment. The been measured a confocal method obtain three-dimensional parameters flow cytometry (p-DIFC) image texture parameters. support vector...
T lymphocytes are the most important immune cells that affect both development and treatment of hepatitis B. We used high-throughput sequencing to determine diversity in V J regions TCR β chain 4 chronic B patients before after HBeAg seroconversion. Here, we demonstrate expressed<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi mathvariant="normal">V</mml:mi><mml:mi mathvariant="normal">β</mml:mi><mml:mn mathvariant="normal">12</mml:mn></mml:math>-4 at highest...
Cytotoxic T lymphocytes (CTLs) are important for the recognition of hepatitis B virus (HBV), mediating immunoprotective mechanisms and determining clinical outcome following HBV infection. CTLs recognize invading via cell receptor (TCR). The aim current study was to investigate variability TCR in from patients with chronic whether genomic recombination is regulated by treatment strategies. Peripheral blood mononuclear cells (PBMCs) were isolated high‑throughput sequencing performed analyze...
High mobility group box chromosomal protein 1 (HMGB1) is an important proinflammatory molecule in a number of inflammatory disorders, but little known about its role acute-on-chronic liver failure (ACLF). To elucidate the HMGB1 ACLF, expression specimens from patients with ACLF was investigated. Immunohistochemical staining performed to confirm and subcellular localization obtained 13 caused by hepatitis B virus (HBV) infection, 20 chronic viral healthy controls. In addition, TFK-1 cells...
ObjectivesThe purpose of this study was to analyze the clinical characteristics chronic hepatitis B (CHB) cured by antiviral therapy.MethodsForty-two patients with CHB were enrolled. All had been treated peginterferon (Peg-IFN) in combination nucleoside analogue (NA) therapy for variable amounts time, and all successfully disease.ResultsThe combined treatment time participants 124.7 ± 58.8 weeks, average Peg-IFN 102.6 56.1 weeks. At 24 Hepatitis surface antigen (HBsAg) e (HBeAg) decreased...
Hepatocellular carcinoma (HCC) is a common malignancy worldwide. Alpha-fetoprotein (AFP) still the only serum biomarker widely used in clinical settings. However, approximately 40% of HCC patients exhibit normal AFP levels, including very early and AFP-negative HCC; for these patients, not applicable as detection. Thus, there an urgent need to identify novel biomarkers whom disease cannot be diagnosed early. In this study, we screened identified proteins evaluated feasibility using...
<title>Abstract</title> <bold>Background: </bold>Our study aimed to determine the incidence, patient characteristics, and clinical outcomes of patients with newly diagnosed myeloma (NDMM) bone marrow fibrosis (BMF). <bold>Methods:</bold> The data, histological features, NDMM were collected. Reticular fiber staining was performed on enrolled cases, degree reticular hyperplasia graded, incidence BMF calculated. differences in between BMF+ group BMF– compared. <bold>Results:</bold> involved a...
Gastric cancer (GC) is the fourth most common worldwide, with overall 5-year survival rate of approximate 20%. Although multimodal treatments that combine surgery chemotherapy and immunotherapy have been shown to improve survival, pathological complete response (pCR) rare in advanced GC patients liver metastases. Pre-clinical studies clinical trials demonstrated antitumor efficacy invariant natural killer T (iNKT) cells various malignancies, including GC. While therapy comprised...
We acquired confocal image stacks from human CD4+ and CD8+ T lymphocytes extracted spleen tissues to reconstruct quantify their 3D morphology. Statistically significant differences in nuclear volume were found between the two subtypes.
Hepatocyte nuclear factor 1α (HNF1α) plays essential roles in controlling development and metabolism; its mutations are clearly linked to the occurrence of maturity-onset diabetes young (MODY3) humans. Lysine 117 (K117) glutamic acid (E117) mutation HNF1α gene has been clinically associated with MODY3, but no functional data on this variant available. Here, we addressed role lysine function using a knock-in animal model site-directed mutagenesis. K117E homozygous mice exhibited dwarfism,...
The aim of this study is to investigate the clinical characteristics and diagnostic therapeutic methods bladder metastasis after radical prostatectomy improve its diagnosis treatment.The data four patients with were retrospectively analyzed from January 2011 December 2021. Three cases suffered intermittent gross hematuria, only one case was found have an elevated prostate-specific antigen (PSA) value. Transurethral resection tumor performed in cases, which also underwent urethral mass....
<h3>Background</h3> Hepatocellular carcinoma remains a leading cause of mortality worldwide, accounting for over three quarter million deaths annually.<sup>1</sup> While transarterial chemoembolization (TACE) therapy is the current first-line intervention roughly 70–80% cases which are non-resectable,<sup>2–6</sup> repeated treatments quickly lead to recalcitrance in recurring tumors, and 5-year survival rates linger at an abysmal 18%.<sup>7</sup> The results our phase 1 trial indicated that...
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) was positively correlated with serological hepatitis surface antigen (HBsAg) levels in e (HBeAg) positive chronic (CHB) patients. We evaluated whether Thymopentin (TP5) and interferon (IFN-a) had a synergic effect on HBV cccDNA the of TP5 addition therapy HBsAg clearance CHB Real-time PCR experiments were performed to test HepG2.2.15 cells. 45 HBeAg-positive patients been distributed into two groups randomly. Treatment group: 23...
Abstract Objectives: Patients with hepatorenal syndrome-acute kidney injury (HRS-AKI) based on acute-on-chronic liver failure (ACLF) have a high rate of mortality. Terlipressin combined albumin is the first line therapy for HRS-AKI in cirrhosis, however, whether it more effective than alone ACLF unclear. We aimed to analyze therapeutic effects terlipressin these patients. Methods: A retrospective study was conducted patients at Beijing You’an Hospital between October 2010 and 2019. The...