A5101427950- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Risk Factors
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Sirtuins and Resveratrol in Medicine
- Gastric Cancer Management and Outcomes
- Autophagy in Disease and Therapy
- Antiplatelet Therapy and Cardiovascular Diseases
- Esophageal Cancer Research and Treatment
- Acute Myocardial Infarction Research
- Metastasis and carcinoma case studies
- Cardiovascular Health and Disease Prevention
- Esophageal and GI Pathology
- Endoplasmic Reticulum Stress and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Artery Anomalies
- Health Systems, Economic Evaluations, Quality of Life
- Protease and Inhibitor Mechanisms
- Anesthesia and Pain Management
Soochow University
2012-2025
Air Force Medical University
2009-2024
Third Affiliated Hospital of Zhengzhou University
2024
Boehringer Ingelheim (Germany)
2021-2024
Fourth People’s Hospital of Jinan
2024
Shandong First Medical University
2024
Kaiser Permanente Center for Health Research
2022-2024
Boehringer Ingelheim (Egypt)
2023
Capital Medical University
2021
National Clinical Research
2021
The effects of systolic blood pressure (SBP), serum total cholesterol (TC), fasting plasma glucose (FPG), and body mass index (BMI) on the risk cardiovascular diseases (CVD) have been established in epidemiological studies, but consistent estimates effect sizes by age sex are not available.We reviewed large cohort pooling projects, evaluating baseline or usual exposure to metabolic risks ischemic heart disease (IHD), hypertensive (HHD), stroke, diabetes, and, as relevant selected other CVDs,...
This study aims to analyze the adverse drug events (ADEs) associated with tolvaptan in Food and Drug Administration Adverse Event Reporting System database from fourth quarter of 2009 second 2024. After standardizing data, various signal detection techniques, including Odds Ratio (ROR), Proportional (PRR), Bayesian Confidence Propagation Neural Network, Multi-Item Gamma Poisson Shrinker, were employed for analysis. Among 7,486 ADE reports where was primary suspected drug, a total 196...
Abstract Aims Contemporary estimates of heart failure (HF) prevalence in Japan are scarce. We aimed to estimate HF and trends using nationally representative, large administrative claims databases. Methods results This retrospective analysis used data from the Medical Data Center (JMDC) (age ≤74 years) Vision (MDV) (all ages) databases (study period: 1 January 2014–31 December 31 2019). calculated crude sex‐/age‐standardized models (weighting based on Japanese census data, 2014–2019). Among...
Abstract Background To investigate the efficacy of different doses corticosteroids in treating severe coronavirus disease 2019 (COVID-19) pneumonia. Methods Between May 01, 2023, and June 20, 48 patients with COVID-19 pneumonia were treated at Department Respiratory Critical Care Medicine Jinan Fourth People's Hospital. The observation group (21 patients) received standard care high-dose corticosteroids, (high-dose group). control (27 low-dose (low-dose We collected baseline data recorded...
Performances of the Acute Physiology and Chronic Health Evaluation II (APACHE II) score Sequential Organ Failure Assessment (SOFA) were assessed in predicting mortality outcome critically ill elderly patients.Mean APACHE SOFA scores compared 106 intensive care unit patients aged > 65 years classified as survivors or deaths. The discriminatory ability was evaluated using area under receiver operating characteristic (ROC) curve. Calibration Hosmer-Lemeshow test.Mean lower than those who died....
Hypoxic microenvironments play a significant role in the progression of colorectal cancer (CRC). Silencing information regulator 1 (SIRT1), class III histone deacetylase, modulates multiple biological behaviors cancer. However, its CRC remains unclear. This study aims to explore SIRT1 migration and invasion under hypoxia.SIRT1 protein mRNA levels were detected by Western blotting real-time PCR cells exposed hypoxia (1% O2). The abilities SW480 HCT116 with overexpression or knockdown studied...
Circadian negative feedback loop (CNFL) genes play important roles in cancer development and progression. To evaluate the effects of single nucleotide polymorphisms (SNPs) CNFL on survival GC patients, 13 functional SNPs from 5 were genotyped a cohort 1030 resected patients (704 training set, 326 validation set) to explore association with overall (OS). Among SNPs, three (rs1056560 CRY1, rs3027178 PER1 rs228729 PER3) significantly associated OS verified set pooled analysis. Furthermore,...
Sirtuin1 (SIRT1) is a mammalian NAD+-dependent type III deacetylase that plays paramount roles in diverse cellular processes. The nucleocytoplasmic shuttling of SIRT1 was discovered more than decade ago, but the subcellular localization tumor progression remain unclear. Here, we report cytoplasmic acts as suppressor ovarian carcinoma. By creating carcinoma cell lines overexpressing wild-type and nuclear signals (NLSs) mutated together with both unbiased proteomic acetylomic approaches...
Background Stenting of airway stenosis is a common procedure in specialized centers. The aim this study was to summarize our clinical experience ventilation strategy and anesthesia management patients undergoing urgent tracheal stenting. Methods Clinical data 22 with severe who underwent endoscopic placement stent during 2‐year period were retrospectively reviewed. efficacy safety different strategies veno‐arterial extracorporeal membrane oxygenation ( ECMO ), individualized based on the...
Abstract Therapeutic resistance is a notable cause of death in patients with ovarian carcinoma. Polyploid giant cancer cells (PGCCs), commonly arising tumor tissues following chemotherapy, have recently been considered to contribute drug resistance. As type III deacetylase, Sirtuin1 (SIRT1) plays essential roles the cell cycle, cellular senescence, and Accumulating evidence has suggested that alteration its subcellular localization via nucleocytoplasmic shuttling critical process influencing...
Background: Aspergillus has become the second most common causative agent of invasive fungal infections and is leading cause death from infections. Methods: English‐language publications ranging 1975 to 2022 collected Web Science Core Collection database were analyzed visually using VOSviewer, R package Bibliometrix, Scimago graphic, Gephi, Pajek, Microsoft Excel 365. Literature search advanced function in WoSCC with formula “TS=(Aspergillus).” The inclusion criteria as follows: (1) article...
Abstract Immune checkpoint inhibitors combined with chemotherapy have shown promising efficacy in treating gastric or gastroesophageal junction (G/GEJ) adenocarcinoma the neoadjuvant setting. This phase II trial (NCT05715632) aimed to investigate and safety of perioperative camrelizumab plus XELOX patients locally advanced G/GEJ adenocarcinoma. Treatment‐naive cT3‐4aN1‐3 M0 resectable were recruited receive (200 mg, intravenously) on Day 1 (oxaliplatin at 130 mg/m 2 capecitabine 1000 Days...
Introduction Aspirin is an effective antiplatelet drug for preventing cardiovascular events in high-risk subjects. However, patients with chronic kidney disease and undergoing hemodialysis (HD), its preventive efficacy remains controversial. The present study aimed to determine whether aspirin therapy reduces the risk of (CVD) all-cause mortality on HD. Methods We conducted a 5-y prospective cohort involving Major exposure variables included prescription (100 mg/d) no (nonaspirin). primary...
This study investigated selenoprotein P expression, using immunohistochemistry, in gastric adenocarcinoma tissue microarrays constructed from 30 specimens and normal tissues (controls). Selenoprotein expression scores were significantly lower (17/30, 56.7%) than control (25/30, 83.3%). was more likely to be expressed well-to-moderately differentiated cases (13/17, 76.5%) with low differentiation (4/13, 30.8%) there no significant difference between tumour node metastasis (TNM) stage I – II...
A simplified model not requiring a clinic visit is important for cardiovascular prevention. We compared such model, with one clinical measurements prediction of ischemic stroke.Five population-based Finnish cohorts comprising 14 296 men and 16 065 women aged 25-64 years were randomly recruited from 1982, followed up using the national registers until end 2007. The final Cox included age, prior history diabetes hypertension, happy marriage, capability to walk 500 m (self-estimate), regular...