A5076399295- Metabolism and Genetic Disorders
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Reproductive System and Pregnancy
- Wnt/β-catenin signaling in development and cancer
- CAR-T cell therapy research
- Infant Nutrition and Health
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- Fluoride Effects and Removal
- Pregnancy and Medication Impact
- RNA modifications and cancer
- S100 Proteins and Annexins
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Vascular Malformations and Hemangiomas
- RNA and protein synthesis mechanisms
- Nerve injury and regeneration
- Developmental Biology and Gene Regulation
- Birth, Development, and Health
- RNA Interference and Gene Delivery
Niigata University
2016-2024
Niigata University of Pharmacy and Medical and Life Sciences
2024
Niigata University Medical and Dental Hospital
2018-2020
Nara Medical University
1991-2017
Vanderbilt University Medical Center
2015
Nagoya City University
2013
Nagoya University
2013
Okayama University
2013
Aichi Cancer Center
2013
Kawasaki Medical School
2013
Protein kinase C (PKC) has been implicated in the Wnt signaling pathway; however, its molecular role is poorly understood. We identified novel genes encoding δ-type PKC Xenopus EST databases. Loss of PKCδ function revealed that it was essential for convergent extension during gastrulation. then examined relationship between and pathway. translocated to plasma membrane response Frizzled signaling. In addition, loss inhibited translocation Dishevelled activation c-Jun N-terminal (JNK) by...
The diverse localization of transcripts in cells suggests that there are many specific RNA–protein interactions have yet to be identified. Progress has been limited, however, by the lack a robust method detect and isolate RNA-binding proteins. Here we describe use an RNA aptamer, scaffolded tRNA, create affinity matrix efficiently pulls down transcript-specific proteins from cell lysates. addition tRNA scaffold Streptavidin aptamer (tRSA) increased binding efficiency ∼10-fold. tRSA system...
Metastatic breast cancer is the leading cause of cancer-associated death in women. The progression this fatal disease associated with inflammatory responses that promote cell growth and dissemination, eventually to a reduction overall survival. However, mechanism(s) inflammation-boosted remains unclear. In study, we found for first time an extracellular cytokine, S100A8/A9, accelerates metastasis upon binding surface receptor, melanoma adhesion molecule (MCAM). Our molecular analyses...
Myristoylated alanine-rich C kinase substrate (MARCKS) is an actin-binding, membrane-associated protein expressed during Xenopus embryogenesis. We analyzed its function in cytoskeletal regulation gastrulation. Here, we show that blockade of impaired morphogenetic movements, including convergent extension. MARCKS was required for control cell morphology, motility, adhesion, protrusive activity, and cortical actin formation embryonic cells. also demonstrate the noncanonical Wnt pathway...
Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology.Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable cancer nests, making it highly difficult cure patients PDAC.However, PDAC also owe intractability other critical factors such as cellular interaction between cells microenvironment well architectural barriers, which increases...
Identifying the specific functional regulator of integrin family molecules in cancer cells is critical because they are directly involved tumor invasion and metastasis. Here we report high expression PLOD2 oropharyngeal squamous cell carcinomas (SCCs) its role as a stabilizer β1, enabling β1 to initiate invasion/metastasis. Integrin stabilized by PLOD2-mediated hydroxylation was recruited plasma membrane, site, accelerated motility, leading metastasis vivo, whereas loss abrogated it. In...
S100A11, a member of the S100 family proteins, is actively secreted from pancreatic ductal adenocarcinoma (PDAC) cells. However, role extracellular S100A11 in PDAC progression remains unclear. In present study, we investigated crosstalking between cells and surrounding fibroblasts progression. An abundant cancer stimulated neighboring through receptor for advanced glycation end products (RAGE) upon binding was followed by not only an enhanced cell motility vitro but also increased number...
MINT‐ 6823820 : axin (uniprotkb: O15169 ) physically interacts (MI: 0218 with beta catenin P35222 by anti tag coimmunoprecipitation 0007
The fertile stroma in pancreatic ductal adenocarcinomas (PDACs) has been suspected to greatly contribute PDAC progression. Since the main cell constituents of are fibroblasts, there is crosstalking(s) between cells and surrounding fibroblasts stroma, which induces a fibroblast proliferation burst. We have reported that several malignant cancer including secrete pronounced level S100A11, turn stimulates via receptor for advanced glycation end products (RAGE) an autocrine manner. Owing RAGE +...
Pancreatic invasive ductal adenocarcinoma (PDAC) is a representative intractable malignancy under the current cancer therapies, and considered scirrhous carcinoma because it develops dense stroma. Both PODXL1, member of CD34 family molecules, C5aR, critical cell motility inducer, have gained recent attention, as their expression was reported to correlate with poor prognosis for patients diverse origins including PDAC; however, previous studies independently on respective biological...
Activation of the epidermal growth factor receptor (EGFR) has been observed in many malignant tumors and its constitutive signal transduction facilitates proliferation tumors. EGFR-tyrosine kinase inhibitors, such as gefitinib, are widely used a molecular-targeting agent for inactivation EGFR signaling show considerable therapeutic effect non-small cell lung cancers harboring activating mutations. However, prolonged treatment inevitably produces with additional gefitinib-resistant mutations...
p14 ARF is one of the major tumor suppressors conventionally identified both as mdm2‐binding molecule restoring p53 function in nucleus, and a nucleophosmin‐binding partner inside nucleolous to stabilize ribosomal RNA. However, its recently reported mitochondrial localization has pointed novel properties suppressor. At same time, functional peptides are gaining much attention nanomedicine for their vivo utility non‐invasive biologics. We previously ‐specific peptide that restored sensitivity...
Epithelial cell polarity regulator Crumbs3 ( Crb3 ), a mammalian homolog within the Drosophila Crb gene family, was initially identified as an essential embryonic development factor. It is recently implicated in tumor suppression, though its specific functions are controversial. We here demonstrate that strongly promotes invasion and metastasis of human colon adenocarcinoma cells. centrality to migration supported by strong expression at invasive front metastatic foci colonic patient...
To compare statistically the clinical effects and postoperative course of scanning CO(2) laser conventional surgical method to evaluate effectiveness former for treatment ingrown nail deformities.We performed vaporization matrix using in 25 cases with deformities.In 21 cases, recurrence deformity was not observed during follow-up. All were free infection. Use reduced pain, all patients able return their daily activities by day 3 post-surgery without any problems.Statistically, operating time...
Despite receiving rituximab‐combined chemotherapy, follicular lymphoma (FL) patients often suffer tumor recurrence and understand that the cause of relapse in FL would thus significantly ameliorate therapeutics. In present study, we show TRA‐1‐60‐expressing cells are a unique population FL, converge to conventional stem cell marker Oct3/4 ALDH1‐positive population, resist current B‐lymphoma agents. TRA‐1‐60 expression was observed scattered tissues only as well resting B‐lymphocytes inside...