A5100345201- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Healthcare and Venom Research
- Bioactive natural compounds
- Pharmacology and Obesity Treatment
- Synthesis of Organic Compounds
- Phytochemistry and Bioactivity Studies
- Flavonoids in Medical Research
- Insect Utilization and Effects
- Mycotoxins in Agriculture and Food
- Cholinesterase and Neurodegenerative Diseases
- Analytical chemistry methods development
- Drug Transport and Resistance Mechanisms
- Trigeminal Neuralgia and Treatments
- Berberine and alkaloids research
- Coffee research and impacts
- Ferroptosis and cancer prognosis
- Neuroendocrine Tumor Research Advances
- Synthesis of Tetrazole Derivatives
- Urticaria and Related Conditions
- Sirtuins and Resveratrol in Medicine
- Synthesis and Catalytic Reactions
- Ginseng Biological Effects and Applications
- Marine Sponges and Natural Products
Zhengzhou University of Light Industry
2024
Minzu University of China
2023-2024
Dalian University of Technology
2022
Dalian University
2022
Shandong University of Technology
2022
China XD Group (China)
2017-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2020
Chinese Academy of Sciences
2019
Sun Yat-sen University
2019
South China Sea Institute Of Oceanology
2019
Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM PTN-PTPRZ1 paracrine signalling. PTN expression correlates with CD11b+/CD163+ and poor prognosis patients. Co-implantation M2-like (MLCs) promoted GSC-driven tumour growth, silencing in...
Atrovimycin (1), a cyclodepsipeptide containing unique vicinal-hydroxylated cinnamic acyl chain, was isolated and elucidated from Streptomyces atrovirens LQ13. The biosynthetic pathway of 1 achieved, revealing cytochrome P450 (Avm43) epoxide hydrolase (Avm29) enzymes constructing the vicinal-dihydroxy substitution, as well tailoring (Avm28) enzyme catalyzing β-hydroxylation l-Phe moiety. shows in vitro antifungal activity antitubercular against Mycobacterium tuberculosis H37Rv both (with MIC...
Cancer is the second leading cause of death worldwide. Edible medicinal mushrooms have been used in traditional medicine as regimes for cancer patients. Recently anti-cancer bioactive components from some isolated and their effects tested. Pleurotus ferulae, a typical edible mushroom Xinjiang China, has also to treat patients folk medicine. However, little studies reported on ferulae. This study aims extract ferulae investigate extracts. We ethanol enriched with terpenoids tested anti-tumour...
Multiflorumisides A–G (1–7), seven new dimeric stilbene glucosides with two rare coupling patterns, were isolated from the roots of Polygonum multiflorum. The structures these elucidated through comprehensive spectroscopic and chemical analyses. absolute configurations 3 5–7 established by comparing their experimental quantum-chemical ECD data. Putative biosynthetic pathways toward dimers suppressive effects against nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells are...
In the process of oil exploitation, water level an well can be predicted and position reservoir estimated by measuring content crude oil, with reference for automatic production high efficiency in field. this paper, a visual method is proposed. The samples were separated centrifugation, distillation or electric dehydration, water-oil layered mixture was formed according to unequal densities. Then volume ratio analyzed digital image processing, able calculated. A new based on IGAVD (image...
Abstract The effect of ozone treatment on the degradation two Alternaria mycotoxins, alternariol (AOH) and monomethyl ether (AME), in both aqueous solution orange juice was investigated. In addition, quality after evaluated. results demonstrated that effectively eliminated AOH AME. an solution, exhibited a reduction 57.95%, while AME decreased by 40.24% 5 s treatment. And toxins could be almost completely degraded within 40 s. Moreover, alkaline condition with pH value 10 facilitated...
Lenalidomide, an immunomodulatory agent, and flavopiridol, a broad cyclin-dependent kinase inhibitor, are active therapies for clinical use in genomic high-risk chronic lymphocytic leukemia. A high-performance liquid chromatographic assay with tandem mass spectrometric detection has been developed to simultaneously quantify lenalidomide flavopiridol human mouse plasma facilitate their combined development. Samples were prepared by liquid-liquid extraction acetonitrile (ACN)-containing...
New cationic polymeric nanoparticles were synthesised with high adsorption capacities for diclofenac sodium and showed fast desorption.
Pancreatic cancer has a high degree of malignancy and low 5-year survival rate, drug resistance is one the main factors leading to poor prognosis pancreatic cancer. Wogonin flavonoid isolated from Scutellaria baicalensis, which certain antitumor activity. Hence purpose this study was investigate whether wogonin can be used enhance sensitivity gemcitabine chemotherapy, its possible sensitization mechanism. In vitro, MTT assay showed that increased cytotoxicity in gemcitabine-resistant cells....
A series of terpenoids (1-17), comprising six new compounds designated bipolariterpenes A-F (1-6) and eleven recognized (7-17), were isolated from the wheat culture potato endophytic fungus Bipolaris eleusines. Their structures stereochemistry clarified by HRESIMS, NMR, DP4 + probability analyses, computations for electronic circular dichroism (ECD). All are made up meroterpenoids, four sesterterpenes seven sesquiterpenes. Among them, (4, 5, 10, 11) investigated their antifungal,...
Wen-Xin Xianga*, Qing Liua*, Xiao-Man Lia, Chun-Hua Lua* & Yue-Mao Shenaa Key Laboratory of Chemical Biology (Ministry Education), School Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. China
In this study, two “on–off” probes (BF2-cur-Ben and BF2-cur-But) recognizing acetylcholinesterase (AChE) were designed synthesized. The obtained can achieve recognition of AChE with good selectivity pH-independence a linear range 0.5~7 U/mL 0.5~25 respectively. BF2-cur-Ben has lower limit detection (LOD) (0.031 U/mL), higher enzyme affinity (Km = 16 ± 1.6 μM), inhibitor sensitivity. A responsive mechanism the for was proposed based on HPLC mass spectra (MS) experiments, as well calculations....
Human leukocyte antigen (HLA)-B*5701 is strongly associated with developing a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*5701 prevalence in HIV-1-infected subjects China. We investigated population including Han and non-Han ethnic groups.A prospective multi-centre study was designed determine status of adults at six sites across tested by the method PCR-SSP.From centers, 3,000 HIV-infected patients [2,452 (81.7%) Han, 548 (18.3%) Non-Han] were recruited mean age...
We synthesized two calcium salts of 3,6-bis(1H-1,2,3,4-tetrazol-5-yl-amino)-1,2,4,5-tetrazine (BTATz): [Ca2(BTATz)2(H2O)8·6H2O] (1) and Ca(BTATz)(phen)(H2O)5·4H2O (2). Complexes 1 2 were characterized by elemental analysis, Fourier transform infrared spectrometry, single-crystal X-ray diffraction. Structural analysis revealed that Ca(II) was present in different coordination structures the complexes. Complex exhibited a symmetric octahedral included three nitrogens five water molecules....
The interaction of silica nanoparticles (SiO2NPs) with berberine hydrochloride (BRH) was studied in aqueous solution at pH 9.0 and room temperature by using fluorophotometry. Based on a significant enhancement the fluorescence intensity SiO2NPs-BRH aggregates, spectrofluorimetric method which simple, sensitive green developed for determination BRH solution. linear range from 2.0-50.0 μg L-1 detection limit 0.73 L-1. There no interference compounds normally used to formulate pharmaceutical...
Inhibition of adipocytes differentiation is suggested to be an important strategy for prevention and/or treatment obesity. In our present study, Cordyceps militaris showed significant inhibitory activity on adipocyte in 3T3-L1 preadipocytes as assessed by measuring fat accumulation using Oil Red O staining. Activity-guided fractionation led the isolation cordycepin (1), guanosine (2) and tryptophan (3) active compounds. All three compounds were more effective early stage adipogenesis than...
Obesity, which is characterized by excessive fat accumulation, occurs absorption lipase and sequential accumulation in adipocytes through adipocyte differentiation. Thus, inhibition of pancreatic activity differentiation would be crucial for the prevention treatment obesity. Investigation anti-obesity compounds from Parthenocissus tricuspidata stems resulted isolation nineteen including five acetophenones, flavonoids nine stilbene derivatives. Among them, derivatives showed most potent...
Tectorigenin (TEC) is an effective compound that derived from many plants, such as Iris unguicularis, Belamcanda chinensis and Pueraria thunbergiana Benth. Evidence suggested TEC has anti-tumor, anti-oxidant activity, anti-bacterial anti-inflammatory effects. In addition, there some evidence indicated a potential anti-stroke compound; however, its specific roles associated mechanism have not yet been elucidated. the present study, we aimed to investigate anti-inflammatory, activity...
Abstract Two new complexes, [Ni(dpypda)(H 2 O) 3 ]·(fum) ( 1 ) and [Cu (dpypda) (fum) ] n ·8 H O (dpypda= N , 4 ‐di(pyridin‐2‐yl)pyrimidine‐2,4‐diamine, fum=fumarate), have been synthesized characterized by single‐crystal X‐ray diffraction. Complex is a discrete unit, exhibiting (4,5,6)‐connected framework formed hydrogen bonding interactions electrostatic between free fum dianions mononuclear 2+ cations. However, in complex two crystallographically independent adopt the alternative mode of...
Abstract The study examined the impact of jujube constituents on cold plasma (CP) degradation alternariol (AOH) and monomethyl ether (AME), followed by assessing changes in CP electrochemical properties. correlation between these properties toxin was analyzed to understand how components influence breakdown AOH AME. Results showed that when treated with for 3 minutes, 0.00350 mg/mL protein degraded 49.0% 48.8% Under same treatment time, 0.0500 polysaccharide 74.6% AME 95.8%. Conversely, Vc,...