A5040908974- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Parkinson's Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Chemical Synthesis and Analysis
- Historical Medical Research and Treatments
- Receptor Mechanisms and Signaling
- Ginkgo biloba and Cashew Applications
- Neurogenesis and neuroplasticity mechanisms
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Chemical synthesis and alkaloids
- Endoplasmic Reticulum Stress and Disease
- Nuclear Receptors and Signaling
- Forest Biomass Utilization and Management
- Click Chemistry and Applications
- Barrier Structure and Function Studies
University of Latvia
2016-2025
Unidad de Cirugía Artroscópica
2018
Foundation for Ichthyosis and Related Skin Types
2018
Latvia University of Life Sciences and Technologies
2018
Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting millions of people worldwide. At present, there no effective cure for PD; treatments are symptomatic and do not halt progression neurodegeneration. Extracellular vesicles (EVs) can cross blood–brain barrier represent promising alternative to classical treatment strategies. In present study, we examined therapeutic effects intranasal administration EVs derived from human exfoliated deciduous teeth...
Neuroinflammation, oxidative stress, decreased glucose/energy metabolism, and disrupted neurotransmission are changes that occur early in sporadic Alzheimer's disease (AD), manifesting as mild cognitive impairment. Recently, the imbalanced function of gamma-aminobutyric acid (GABA) system was identified a critical factor AD progression. Thus, maintaining balance among neurotransmitter systems, particularly GABA system, can be considered beneficial strategy to slow The present study...
This study aimed to evaluate the hepatoprotective effects of nettle (Urtica dioica L.) leaf water extracts on oxygen consumption in fatty acid oxidation (FAO) pathway using an vitro liver HepG2 cell model and employing oxygraphy approach. It also examined impact these lipid accumulation viability under oxidative stress. The were obtained via maceration with preservatives or by sonication with/without preservatives. Their chemical composition, including polyphenols, vitamins, minerals, was...
Alzheimer’s disease (AD) is the most common cause of dementia. Fingolimod has previously shown beneficial effects in different animal models AD. However, it contradictory when been applied at early stages. Our objective was to evaluate fingolimod two treatment paradigms. To address this aim, we treated male and female APP-transgenic mice for 50 days, starting either before plaque deposition days age (early) or 125 (late). effects, investigated neuroinflammatory glial markers, Aβ load,...
The novel 1,4-dihydropyridine derivatives containing the cationic pyridine moiety at position 4, and N-propargyl group as a substituent 1 of 1,4-DHP cycle were designed, synthesised, assessed in biological tests. Among all compounds, 4-(N-dodecyl) pyridinium group-containing compounds 11 (without group) 12 (with demonstrated highest calcium antagonistic properties against neuroblastoma SH-SY5Y (IC50 about 5–14 μM) vascular smooth muscle A7r5 cell – 0.6–0.7 lines, indicating that they...
Amyloid-β (Aβ) deposition is one of the hallmarks amyloid hypothesis in Alzheimer's disease (AD). Mouse models using APP-transgene overexpression to generate plaques have shown model only certain parts disease. The extent which data from mice can be transferred man remains controversial. Several studies convincing treatment results reducing Aβ and enhancing cognition but failed totally human. One model-dependent factor has so far been almost completely neglected: endogenous expression mouse...
Abstract Polyprenols (PPs) have been identified in almost all living organisms. The richest source of PPs is the needles conifer trees. Endogenously, PPs, similarly to cholesterol, are synthesised human and animal cells via mevalonate pathway. Previous studies demonstrated anti-oxidant properties PPs. To our knowledge, no published on influence muscle strength. We hypothesised that administration could prevent changes functioning caused by statins (weakness, etc.). In present study,...
Sharing and developing digital educational resources open has been proposed as a way to harmonize improve clinical pharmacology therapeutics (CPT) education in European medical schools. Previous research, however, shown that there are barriers the adoption implementation of resources. The aim this study was determine perceived opportunities use creation among CPT teachers possible solutions for these barriers.
Previously, we have found that mildronate [3-(2,2,2-trimethylhydrazinium) propionate dihydrate], a small molecule with charged nitrogen and oxygen atoms, protects mitochondrial metabolism is altered by inhibitors of complex I has neuroprotective effects in an azidothymidine-neurotoxicity mouse model. In the present study, investigated rat model Parkinson’s disease (PD) was generated via unilateral intrastriatal injection neurotoxin 6-hydroxydopamine (6‑OHDA). We assessed expression cell...
Background. Mildronate (3-[2,2,2-trimethylhydrazinium] propionate dihydrate) traditionally is a well-known cardioprotective drug. However, our recent studies convincingly demonstrated its neuroprotective properties. The aim of the present study was to evaluate influence mildronate on expression proteins that are involved in differentiation and survival nigrostriatal dopaminergic neurons rat model Parkinson’s disease (PD). following biomarkers were used: heat shock protein 70 (Hsp70,...
Mildronate, a carnitine congener drug, previously has been shown to provide neuroprotection in an azidothymidine‐induced mouse model of neurotoxicity and Parkinson's disease rat model. The aim this study was investigate the effects mildronate treatment on cognition pathology Alzheimer's (AD) mice (APP SweDI ). Mildronate administered i.p. daily at 50 or 100 mg/kg for 28 days. At end treatment, animals were behaviorally cognitively tested, brains assessed AD‐related pathology, inflammation,...
Ca2+ blockers, particularly those capable of crossing the blood-brain barrier (BBB), have been suggested as a possible treatment or disease modifying agents for neurodegenerative disorders, e.g., Alzheimer's disease. The present study investigated effects novel 4-(N-dodecyl) pyridinium group-containing 1,4-dihydropyridine derivative (AP-12) on cognition and synaptic protein expression in brain. Treatment AP-12 was wild type C57BL/6J mice transgenic model (Tg APPSweDI) using behavioral tests...
The needles of conifer trees are one the richest sources natural polyprenols. Polyprenol homologs from Abies sibirica L. lipophilic 80% purified extract were analyzed and quantified. In total, 10 peaks (Prenol-11 to Prenol-20) observed in ultra-high-performance liquid chromatography–diode array detector (UHPLC-DAD) chromatogram Siberian fir with most abundant compound being Prenol-15 (relative amount 37.23 + 0.56% total polyprenol yield). solubility incorporation efficiency into liposomes...
Background and Objectives: Dissecting the complex pathological cascade of an ischemic stroke in preclinical models is highly warranted to understand course this disease humans. Neurogenesis angiogenesis are integral for post-stroke recovery, yet it not clear how these processes altered months after stroke. In study, we investigated changes that take place subacutely focal cerebral ischemia experimental adult male mice. Materials Methods: Male 12-week-old C57BL/6 mice underwent a 60 min long...