A5044167903- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Crystallography and molecular interactions
- Erythrocyte Function and Pathophysiology
- Hematopoietic Stem Cell Transplantation
- Plant Disease Resistance and Genetics
- Immune cells in cancer
- Phytochemistry and Biological Activities
- Phagocytosis and Immune Regulation
- Plant Pathogens and Resistance
- Hemoglobinopathies and Related Disorders
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Essential Oils and Antimicrobial Activity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Curcumin's Biomedical Applications
- Thermal Regulation in Medicine
- Fungal Plant Pathogen Control
- Food composition and properties
- Microbial infections and disease research
- Bee Products Chemical Analysis
- Immune Response and Inflammation
- Transplantation: Methods and Outcomes
The University of Queensland
2016-2024
Mater Research
2016-2024
Translational Research Institute
2016-2023
Govind Ballabh Pant University of Agriculture and Technology
2007-2019
Harvard University
2014-2019
Beth Israel Deaconess Medical Center
2014-2019
Prince Charles Hospital
2018
Griffith University
2009-2016
National Heart Foundation of Australia
2012-2016
Heart Foundation
2014
A protective association between bilirubin and atherosclerosis/ischemic heart disease clearly exists in vivo. However, the relationship vivo oxidative stress parameters a clinical population remains poorly described. The aim of this study was to assess whether persons expressing Gilbert syndrome (GS; i.e., unconjugated hyperbilirubinemia) are protected from thiol oxidation determine if this, addition their improved lipoprotein profile, could explain reduced oxidized low-density (oxLDL)...
Severe viral respiratory infections are often characterised by extensive myeloid cell infiltration and activation persistent lung tissue injury. However, the immunological mechanisms driving excessive inflammation in remain poorly understood.To identify that drive immune recruitment during novel drug targets to reduce disease severity.Preclinical murine models of influenza A virus severe acute syndrome coronavirus 2 (SARS-CoV-2) infection.Oxidised cholesterols oxysterol-sensing receptor...
Augmented renal clearance (ARC) is being increasingly described in neurocritical care practice. The mechanisms driving this phenomenon are largely unknown. aim of project was therefore to explore changes function, cardiac output (CO), and atrial natriuretic peptide (ANP) concentrations patients with isolated traumatic brain injury (TBI). This prospective observational cohort study conducted a tertiary-level, university-affiliated intensive unit (ICU). Patients normal plasma creatinine (<120...
// Zsuzsanna Nemeth 1, 4 , Eva Csizmadia 1 Lisa Vikstrom Mailin Li Kavita Bisht 5 Alborz Feizi Sherrie Otterbein 6 Brian Zuckerbraun Daniel B. Costa 2, 3 Pier Paolo Pandolfi Janos Fillinger 7 Balazs Döme 4, 8, 9 Leo E. Barbara Wegiel 2 Department of Surgery, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard School, Boston, MA, USA Cancer Center Medicine, Tumor Biology, National Koranyi Institute TB and Pulmonology, Budapest, Hungary Heart Foundation Research Griffith...
Sepsis is a multi-system syndrome that remains the leading cause of mortality and critical illness worldwide, with hemodynamic support being one cornerstones acute management sepsis. We used an ovine model endotoxemic shock to determine if 0.9% saline resuscitation contributes lung inflammation injury in respiratory distress syndrome, which common complication sepsis, investigated potential role matrix metalloproteinases this process.Endotoxemic was induced sheep by administration escalating...
Macrophages play a crucial role in the maintenance and resolution of inflammation express number pro- anti-inflammatory molecules response to stressors. Among them, complement receptor 5a (C5aR) plays an integral development inflammatory disorders. Biliverdin bilirubin, products heme catabolism, exert effects inhibit activation. Here, we define biliverdin on C5aR expression macrophages roles Akt mammalian target rapamycin (mTOR) these responses. administration inhibited lipopolysaccharide...
Sepsis is associated with abnormal host immune function in response to pathogen exposure, including endotoxin (lipopolysaccharide; LPS). Cytokines play crucial roles the induction and resolution of inflammation sepsis. Therefore, primary aim this study was investigate effects endogenous tetrapyrroles, biliverdin (BV) unconjugated bilirubin (UCB) on LPS-induced cytokines human blood. Biliverdin UCB are by products haem catabolism have strong cytoprotective, antioxidant anti-inflammatory...
Three Himalayan Erigeron (Asteraceae) species viz mucronatus, annuus and karwinskianus growing in sub-alpine region revealed occurrence of isomeric polyacetylenic constituents viz., matricaria lachnophyllum esters which accounted for 83.3%, 69.3% 30.1% the essential oils from these species, respectively, addition to mono- sesquiterpenoids as minor constituents. The antifungal activity tested by poisoned food (PF) techniques against Fusarium oxysporum, Helminthosporium maydis, Rhizoctonia...
In normoxia, hypoxia-inducible transcription factors (HIFs) are rapidly degraded within the cytoplasm as a consequence of their prolyl hydroxylation by oxygen-dependent hydroxylase domain (PHD) enzymes. We have previously shown that hematopoietic stem and progenitor cells (HSPCs) require HIF-1 for effective mobilization in response to granulocyte colony-stimulating factor (G-CSF) CXCR4 antagonist AMD3100/plerixafor. Conversely, HIF PHD inhibitors stabilize protein vivo enhance HSPC G-CSF or...
Biliverdin reductase (BVR)-A is a pleotropic enzyme converting biliverdin to bilirubin and signaling molecule that has cytoprotective immunomodulatory effects. We recently showed inhibits the expression of complement activation fragment 5a receptor one (C5aR1) in RAW 264.7 macrophages. In this study, we investigated role BVR-A determining macrophage inflammatory phenotype function via regulation C5aR1. assessed C5aR1, M1-like markers, including chemokines (RANTES, IP-10), as well chemotaxis...
Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency and results in persistent low blood erythrocytes hemoglobin, fatigue, weakness early death. AI common people with chronic inflammation, infections or sepsis. Although several studies have reported effect on stress erythropoiesis homeostasis, mechanisms by which suppresses bone marrow, where differentiation maturation erythroid cells from hematopoietic stem occurs, not been extensively studied. Here we show...
Summary Four mungbean products namely, whole fried namkeen , dehusked roasted and salad were formulated using three different cultivars of viz. UPM 98‐1, Pant Mung‐5 Mung‐2 the effect processing methods on texture nutrient composition studied. All found to be acceptable by panel. Salad was most product with overall acceptability 8.31 out 10 followed (7.80), (7.61) (7.02). Moisture protein content increased significantly after germination for 24 h. Fat deep products. Total ash, crude fibre...
Neurogenic heterotopic ossifications (NHO) are bones that develop in periarticular muscles after severe central nervous system (CNS) injuries. Several retrospective studies have shown NHO prevalence is higher patients who suffer concomitant infections. However, it unclear whether these infections directly contribute to development or reflect the immunodepression observed with CNS injury. Using our mouse model of induced by spinal cord injury (SCI) between vertebrae T
Abstract Background A lung transplant is the last resort treatment for many patients with advanced disease. The majority of donated lungs come from donors following brain death (BD). endothelin axis upregulated in blood and donor after BD resulting systemic inflammation, damage poor graft outcomes recipient. Tezosentan (endothelin receptor blocker) improves pulmonary haemodynamic profile; however, it induces adverse effects on other organs at high doses. Application ex vivo perfusion (EVLP)...
Organs procured following brain stem death (BSD) are the main source of organ grafts for transplantation. However, BSD is associated with inflammatory responses that may damage and affect both quantity quality organs available transplant. Therefore, we aimed to investigate plasma bronchoalveolar lavage (BAL) pro-inflammatory cytokine profiles cardiovascular physiology in a clinically relevant 6-h ovine model BSD.Twelve healthy female sheep (37-42 Kg) were anaesthetized mechanically...
Background: Chronic activation of the innate immune system drives inflammation and contributes to atherosclerosis. Pro-inflammatory agents (oxidised LDL, IL-1β) drive lesional development, whereas anti-inflammatory (IL-10, HDL, Apolipoprotein-AI), promote an milieu resolution. RIPK1 (Receptor interacting protein kinase 1) is a master regulatory gene that decides whether cell undergoes inflammation, apoptosis and/or necroptosis, depending on its phosphorylation or ubiquitination status. We...