A5025125509- Ferroptosis and cancer prognosis
- Iron Metabolism and Disorders
- Trace Elements in Health
- Plasma Applications and Diagnostics
- DNA Repair Mechanisms
- Reproductive Biology and Fertility
- Extracellular vesicles in disease
- BRCA gene mutations in cancer
- Occupational and environmental lung diseases
- Cancer, Lipids, and Metabolism
- Endometriosis Research and Treatment
- Advanced biosensing and bioanalysis techniques
- Biomarkers in Disease Mechanisms
- Vascular Tumors and Angiosarcomas
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Uterine Myomas and Treatments
- Pulmonary Hypertension Research and Treatments
- Hemoglobinopathies and Related Disorders
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- Advanced Photocatalysis Techniques
- Nanocomposite Films for Food Packaging
- Sperm and Testicular Function
- PARP inhibition in cancer therapy
- Sarcoma Diagnosis and Treatment
Nagoya University
1959-2025
Kumamoto University
2011-2018
Ovarian endometriosis (OE) provides women of reproductive age with not only severe menstrual pain but also infertility and an increased risk for ovarian carcinogenesis. Whereas peritoneal models have been developed syngeneic implantation minced uterine tissue oncogenic K-ras allele conditional Pten deletion within surface epithelium generated preneoplastic endometrial glandular morphology, followed by endometrioid adenocarcinoma, there has no mouse model OE similar to human counterparts,...
Reactive species are involved in various aspects of neoplastic diseases, including carcinogenesis, cancer-specific metabolism and therapeutics. Non-thermal plasma (NTP) can directly provide reactive species, by integrating atmospheric interjacent molecules as substrates, to represent a handy strategy load oxidative stress situ. NTP causes apoptosis and/or ferroptosis specifically cancer cells types. Plasma-activated Ringer's lactate (PAL) is another modality at the preclinical stage...
Epstein-Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus that causally associated with several malignancies. In addition to latent factors, lytic replication contributes cancer development. this study, we examined whether the gene BNRF1, which conserved among gamma-herpesviruses, has an important role in lymphomagenesis. We found lymphoblastoid cell lines (LCLs) established by BNRF1-knockout EBV exhibited remarkably lower pathogenicity mice xenograft model than LCLs produced...
Oral cancer accounts for ~2% of all cancers worldwide, and therapeutic intervention is closely associated with quality life. Here, we evaluated the effects non-thermal plasma on oral squamous cell carcinoma cells special reference to catalytic Fe(II). Non-thermal exerted a specific killing effect in comparison fibroblasts. Furthermore, was dependent amounts Fe(II), present especially lysosomes. After application, lipid peroxidation occurred peroxides mitochondrial superoxide were generated....
Abstract BRCA1 is one of the causative genes for hereditary breast and ovarian cancer syndrome with a high risk early‐onset cancer. Whereas olaparib (OLA), an inhibitor poly‐ADP‐ribose polymerase, has been applied as adjuvant therapy to those patients, its effect on reproductive function remains unelucidated. Recently, rat model (MUT; Brca1 (L63X/+) mutation) mimicking human pathogenic variant established. Using this model, we evaluated effects OLA in comparison wild‐type (WT) rats. MUT...
Germline-mutation in BRCA1 tumor suppressor gene is an established risk for carcinogenesis not only females but also males. Deficiency the repair of DNA double-strand breaks hypothesized as a responsible mechanism carcinogenesis. However, supporting data insufficient both mutation spectra cancers patients with germline-mutation and murine knockout/knock-in models Brca1 haploinsufficiency. Furthermore, information on driving force toward carriers lacking. Here we applied Fenton reaction-based...
Malignant mesothelioma is an aggressive neoplasm for which effective treatments are lacking. We often encounter cases with a profound desmoplastic reaction, suggesting the involvement of cancer‑associated fibroblasts (CAFs) in progression. While roles CAFs have been extensively studied other tumors and led to view that cancer stroma contains heterogeneous populations CAFs, their remain unknown. previously showed connective tissue growth factor (CTGF), secreted protein, produced by both cells...
We fabricated sensors by modifying the surface of MoS2 and WS2 with COVID-19 antibodies investigated their characteristics, including stability, reusability, sensitivity, selectivity. Thiols disulfanes in strongly interact vacant Mo or W sites WS2, yielding durable devices that are stable for several days air water. More importantly, detachment is suppressed even during aggressive cleaning process at pH 3, which allows reusing same device experiments without appreciable loss sensitivity....
Any independent life requires iron to survive. Whereas deficiency causes oxygen insufficiency, excess is a risk for cancer, generating double-edged sword. Iron metabolism strictly regulated via specific systems, including iron-responsive element (IRE)/iron regulatory proteins (IRPs) and the corresponding ubiquitin ligase FBXL5. Here we briefly reflect history of bioiron research describe major recent advancements. Ferroptosis, newly coined Fe(II)-dependent necrosis, providing huge impact on...
Malignant mesothelioma (MM) is still a social burden associated with asbestos exposure. Local iron accumulation thereby represents the major pathogenesis, followed by oxidative DNA strand breaks and genomic alterations in mesothelium. BRCA1 critical component of homologous recombination repair directed to double-stranded breaks, whereas germline mutation an established risk for breast/ovarian cancer, its role MM development remains be elucidated. Murine Brca1 mutant models so far have not...
Current progress in biology and medical science is based on the observation at level of nanometers via electron microscopy computation. Of note, size most cells higher species exists a limited range from 5 to 50 μm. Recently, it was demonstrated that endogenous extracellular nanoparticles play role communication among various cellular types variety contexts. Among them, exosomes serum have been established as biomarkers for human diseases by analyzing cargo molecules. No life earth can...
Pathogenic variants of BRCA1/2 constitute hereditary breast and ovarian cancer (HBOC) syndrome, mutant is a risk for various cancers. Whereas the clinical guideline HBOC patients has been organized therapy prevention cancer, there no recommendation on female reproductive discipline. Indeed, role pathogenic in reserve not established due to deficiency appropriate animal models. Here, we used rat model Brca2(p.T1942fs/+) Sprague-Dawley strain with CRISPR-Cas9 editing evaluate females....
Pulmonary capillary hemangiomatosis (PCH) is a rare cause of pulmonary hypertension. It characterized proliferation within the alveolar septa. Here, we report case PCH with extensive fibrosis. A 52-year-old man clinical diagnosis non-specific interstitial pneumonia died respiratory failure severe Autopsy revealed pronounced right ventricle hypertrophy and Consistent diagnosis, histological examination diffuse fibrosis, in addition, it also disclosed marked septa as well fibrotic stroma,...
Abstract Nonequilibrium atmospheric pressure plasma has enabled a variety of new applications in medicine, agriculture, and other industries. It is particularly noteworthy that itself and/or plasma‐activated culture medium have been shown to preferentially kill various cancer cells. We previously developed Ringer's lactate solution (PAL) for use as treatment. In this study, behaviors extracellular intracellular reactive oxygen nitrogen species the cellular respiratory system PAL‐treated HeLa...
•A patient had endometrioid adenocarcinoma arising from endometriosis in the canal of Nuck.•The tumor invaded muscles inguinal region.•She showed favorable prognosis by radical surgery and adjuvant chemotherapy.
Plasma-activated chitosan (PAC) colloids for cancer treatment were obtained by using the cold atmospheric plasma technique. Chitosan solutions irradiated ignited in argon gas and a mixture of with nitrogen oxygen gases certain ratios. The structural modifications chemical species generated investigated EPR, LC-MS/MS, XRD, DLS, TGA methods. cell viability test showed selective cytotoxic effect on human breast carcinoma cells (MCF-7), while mammary epithelial (MCF-10A) left unharmed. was...
芳香族アミン類の一種である3,3’-ジクロロ-4,4’-ジアミノジフェニルメタン（MOCA）は，ウレタン樹脂の硬化剤等に産業利用される一方，国際がん研究機関 によりグループ1（ヒトに発がん性あり）に分類され，労働者の健康影響が懸念されている．MOCAの発がん過程には，肝臓をはじめとした各臓器で代謝される際に生じる活性酸素種（ROS）やDNA付加体によるDNA損傷が関係すると考えられているが，その中でもROSによって引き起こされるDNA酸化的損傷である8-ヒドロキシ-2’ -デオキシグアノシン（8-オキソグアニン：8-OHdG）は，高頻度に発生し，DNA複製時のG→Tの点突然変異を惹起する．しかし，実験動物においてMOCAばく露が実際に変異原性の高い8-OHdGを引き 起こすか調べた研究は我々の知る限り存在しない．
Leiomyosarcoma of the inferior vena cava (IVC) is a rare tumor, and it needs complete surgical resection for cure. In addition, reconstruction IVC necessary in many cases. Herein, we indicate case 57-year-old female with leiomyosarcoma segment I IVC, which grew deep into vascular lumen. She underwent en bloc tumor by an artificial pericardium patch.