A5075326339- Amyotrophic Lateral Sclerosis Research
- Long-Term Effects of COVID-19
- Neurogenetic and Muscular Disorders Research
- Peripheral Neuropathies and Disorders
- Peripheral Nerve Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Cervical and Thoracic Myelopathy
- EEG and Brain-Computer Interfaces
- COVID-19 and Mental Health
- Orthopedic Surgery and Rehabilitation
- Epilepsy research and treatment
- Spine and Intervertebral Disc Pathology
- Alzheimer's disease research and treatments
- Cardiac electrophysiology and arrhythmias
- Parvovirus B19 Infection Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Facial Nerve Paralysis Treatment and Research
- Histiocytic Disorders and Treatments
- Infectious Encephalopathies and Encephalitis
- Vagus Nerve Stimulation Research
- Cerebral Palsy and Movement Disorders
- Nerve Injury and Rehabilitation
- Tendon Structure and Treatment
Ospedale Policlinico San Martino
2018-2025
University of Genoa
2018-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
<h3>Background and Objective</h3> A variety of neurological disorders has been reported as presentations or complications COVID-19 infection. The objective this study was to determine their incidence dynamics long-term functional outcome. <h3>Methods</h3> Neuro-COVID Italy a multicentre, observational, cohort with ambispective recruitment prospective follow-up. Consecutive hospitalized patients presenting new associated infection (neuro-COVID), independently from respiratory severity, were...
Background Multiple Sclerosis (MS) is the first cause of non-traumatic neurological disability in young adults. Primary and secondary progressive MS are still lacking effective treatments. A new nutraceutical product made lyophilised leaves bioengineered kiwi plants ( Actinidia deliciosa ) overexpressing osmotin has recently been developed. Osmotin a protein associated with stress adaptation plant cells it shares anti-inflammatory neuroprotective properties mammalian adiponectin. The aim...
Neurological involvement in long COVID (coronavirus disease 2019) is well known. In a previous study we identified two subtypes of neurological COVID, one characterized by memory disturbances, psychological impairment, headache, anosmia and ageusia, the other peripheral nervous system involvement, each which present different risk factor profile. this study, aimed to clarify persistence symptoms with significantly longer term follow-up. We prospectively collected data from patients prior...
We recently reported the potential of Hough transform in delineating spinal cord metabolism by 18F-fluorodeoxyglucose PET/CT scanning amyotrophic lateral sclerosis. The present study aimed to verify relationship between and brain 44 prospectively recruited patients affected sclerosis submitted whole-body PET/CT. Patients were studied highlight presence hypo- or hypermetabolism with respect healthy controls, multiple regression analysis was performed evaluate correlation metabolism. Our...
Abstract Purpose Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease leading to neuromuscular palsy and death. We propose computational approach [18F]-fluorodeoxyglucose (FDG) PET/CT images analyze the structure metabolic pattern of skeletal muscle in ALS its relationship with aggressiveness. Materials methods A 3D method was used extract whole psoas muscle’s volumes average attenuation coefficient (AAC) from CT obtained by FDG performed 62 patients healthy controls. Psoas...
Guillain-Barré syndrome (GBS) is an autoimmune neurological disorder often preceded by viral illnesses or, more rarely, vaccinations. We report on a unique combination of postcoronavirus disease 2019 (COVID-19) vaccine GBS that occurred months after parainfectious COVID-19-related GBS. Shortly manifesting COVID-19 symptoms, 57-year-old man developed diplopia, right-side facial weakness, and gait instability that, together with electrophysiology cerebrospinal fluid examinations, led to...
The aim of our study was to evaluate the role mutations in <i>MAPT</i> gene patients with pure amyotrophic lateral sclerosis (ALS). A cohort 120 ALS patients, both sporadic and familial, without cognitive impairment analyzed by next-generation sequencing a multiple-gene panel comprising 23 genes, including <i>MAPT</i>, known be associated frontotemporal dementia. presence <i>C9orf72</i> expansion also investigated. Twelve had...
The aim of the present study is to describe ultrasound (US) and magnetic resonance imaging (MRI) findings in patients with neuropathies affecting deep (DB) superficial (SB) branches Ulnar nerve (UN) investigate potential role modalities diagnostic workup these conditions.We screened our institutional database identify a diagnosis UN mononeuropathy, among them, we reviewed cases where US disclosed pathological terminal divisions. In this latter subgroup, retrieved available data on MRI...
Recent studies suggest that psychological resilience (PR) is associated with more well-preserved cognition in healthy subjects (HS), but an investigation of such phenomenon patients motor neuron diseases (MNDs) still lacking. The aim our study was therefore to evaluate PR and its relationship baseline cognitive/behavioral mood symptoms, as well longitudinal cognitive functioning, MNDs.
During the COVID-19 pandemic, electroencephalography (EEG) proved to be a useful tool demonstrate brain involvement. Many studies reported non-reactive generalized slowing as most frequent pattern and epileptiform activity in minority of patients.To investigate prevalence diffuse unreactive background attenuation or suppression its correlation with outcome cohort patients.The EEGs recorded during first year pandemic were retrospectively evaluated identify main focus on occurrence low-voltage...
Pure/predominant upper motor neuron (pUMN) and lower (pLMN) diseases have significantly better prognosis compared to amyotrophic lateral sclerosis (ALS), but their early differentiation is often challenging. We therefore tested whether a multimodal characterization approach embedding clinical, cognitive/behavioral, genetic, neurophysiological data may improve the of pUMN pLMN from ALS already by time diagnosis. Dunn’s chi-squared tests were used compare 41 ALS, 34 pLMN, 19 cases with...
Hereditary myopathies represent a clinically and genetically heterogeneous group of neuromuscular disorders, characterized by highly variable clinical presentations frequently overlapping phenotypes with other likely influenced genetic environmental modifiers. Genetic testing is often challenging due to ambiguous diagnosis. Here, we present the case family Electromyography (EMG) features resembling myotonia-like disorder in which Whole Exome Sequencing (WES) analysis revealed co-segregation...
Spinal cord atrophy is one of the hallmarks amyotrophic lateral sclerosis (ALS); however, it not routinely assessed in routine clinical practice. In present study, we evaluated whether spinal cross-sectional area measured at foramen magnum level using a magnetic resonance imaging head scan represents clinically meaningful measure to be added whole-brain volume assessment. Using an active surface approach, and brain parenchymal fraction on T1-weighted three-dimensional spoiled gradient...
Autoimmune encephalitis (AE) is an immune-mediated condition that induces brain inflammation due to several neural-specific autoantibodies. The main triggering and predisposing factors are infections, genetics, the use of immune checkpoint inhibitors tumors. We report a case 57-year-old male with biopsy-confirmed Langerhans cell histiocytosis (LCH) concomitant anti-LGI1 discussing possible relationship in pathogenesis these phenomena. Only sporadic cases AE developing context histiocytic...