A5079128182- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Testicular diseases and treatments
- Ferroptosis and cancer prognosis
- CNS Lymphoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- CAR-T cell therapy research
- Management of metastatic bone disease
- Pituitary Gland Disorders and Treatments
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Salivary Gland Tumors Diagnosis and Treatment
- MRI in cancer diagnosis
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Vascular Malformations Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
Guangdong 999 Brain Hospital
2016-2025
Intracranial non-germinomatous germ cell tumors (NGGCTs) are rare pediatric central nervous system (CNS) tumors. Growth impairment induced by radiation treatment was rarely evaluated. We aimed to evaluate the impacts of radiotherapy on height development as well dosimetric constraints, providing potential insights for hormonal replacement treatment. A total 128 patients diagnosed with NGGCTs were retrospectively studied. Sex, age at irradiation, physical doses and biologically effective dose...
Genetic alterations of chronic active B-cell receptor signaling often occur in primary central nervous system lymphoma (PCNSL). We conducted a phase-II trial high-dose methotrexate plus ibrutinib and temozolomide (MIT) the treatment newly diagnosed PCNSL. A total 35 patients were enrolled, with 33 included analysis. The best overall response rate was 93.9% complete 72.7% for induction therapy. 2-year progression-free survival (PFS) 57.6% (95%CI: 49.0-66.2) 84.8% 78.6-91.0). incidence grade ≧...
Abstract Background and purpose Leptomeningeal metastasis (LM) is a rare but detrimental complication in patients with non-small cell lung cancer (NSCLC). Although whole brain radiotherapy (WBRT) used to eliminating cells or microscopic foci, it becoming less favorable due the concerns over neurocognitive toxicity. This study aimed re-evaluate role of WBRT setting modern targeted therapy. Materials methods From December 2014 March 2019, 80 NSCLC cytologically and/or radiologically proven LM...
Abstract Objectives To evaluate the multiparametric diagnostic performance with non-enhancing tumor volume, apparent diffusion coefficient (ADC), and arterial spin labeling (ASL) to differentiate between atypical primary central nervous system lymphoma (PCNSL) glioblastoma (GBM). Methods One hundred fifty-eight patients pathologically confirmed typical PCNSL ( n = 59), (hemorrhage, necrosis, or heterogeneous contrast enhancement, 29), GBM 70) were selected. Relative minimum ADC (rADC min ),...
Background: Brain necrosis (RN) is a common radiotherapy sequela for brain metastases. Bevacizumab identified as therapeutic strategy RN. This study aimed to the clinical and radiobiological impacts on efficacy of in treating RN following stereotactic radiosurgery (SRS) Methods: From April 2011 November 2019, 40 patients diagnosed with after SRS metastases were retrospectively analyzed. Patients treated follow-up 6 months using MR imaging at different timepoints. Linear regression was...
Molecular characteristics are essential for the classification and grading of gliomas. However, diagnostic midline glioma is still debatable substantial molecular clinical heterogeneity within each subgroup suggested that they should be further stratified. Here, we studied mutation landscape Chinese patients in hope to provide new insights prognosis treatment.Tissue samples from 112 underwent next-generation sequencing targeting 425 cancer-relevant genes. Gene mutations copy number...
Since autophagy and the immune microenvironment are deeply involved in tumor development progression of Lower-grade gliomas (LGG), our study aimed to construct an autophagy-related risk model for prognosis prediction investigate relationship between signature LGG. Therefore, we identified six genes (BAG1, PTK6, EEF2, PEA15, ITGA6, MAP1LC3C) build training cohort (n = 305 patients) verify prognostic validation 128) whole 433), based on data from The Cancer Genome Atlas (TCGA). six-gene could...
Abstract Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) provide a better prognosis in EGFR -mutant non-small cell lung cancer (NSCLC). Nevertheless, the outcome of leptomeningeal metastasis (LM) remains poor. In addition, due to limited access intracranial tumour tissue, gene alterations associated with from adenocarcinoma (LM-LUAD) are unclear. Methods Forty-five patients LM-LUAD May 2019 June 2021 Guangdong Sanjiu Brain Hospital were enrolled this study....
Background Leptomeningeal metastases (LM) have become increasingly common in non-small cell lung cancer (NSCLC) patients who harbor epidermal growth factor receptor ( EGFR ) mutation treated with -TKI and are correlated inferior prognosis. Evidence prior research demonstrated that amplification was more likely presented advanced clinical stages associated worse survival. However, whether is a prognostic marker NSCLC–LM still inconclusive. Methods This study enrolled diagnosed from June 2019...
To investigate the X-ray-specific sensitive genes and potential signaling pathways involved in latent period of radiation-induced lung injury (RILI) mouse models.Mice were randomized into groups for whole thoracic irradiation with a single fraction 20 Gy X-ray or 12.5 carbon heavy ion. Lungs harvested 3 weeks after irradiation, RNA was extracted detected genome-wide transcriptional microarrays. Differentially expressed (DEGs) calculated each group determined, followed by gene enrichment...
Xingrui Chen, Minting Ye, Ruyu Ai, Changguo Shan, Minyao Lai, Weiping Hong, Yanying Yang, Hui Wang, Juan Li, Junjie Zhen, Jiangfen Zhou, Qingjun Hu, Shaoqun Antonio Rossi, Toyoaki Hida, Rafael Rosell, Shuisheng Zhong, Linbo Cai
Gliomas are the malignance of a poor prognosis. The current WHO classification remains unable to predict survival outcomes accurately. Novel surrogates highly required for improved stratification patients and hence, allowing delivery most appropriate treatment.Transcriptional profiles 301 glioma cases on platform Chinese Glioma Genome Atlas (CGGA) were retrospectively studied.Extracellular matrix (ECM) scores established by integrating panel featured gene-signatures, correlating well with...
It is well-known that genomic mutational analysis plays a significant role in patients with NSCLC for personalized treatment. Given the increasing use of stereotactic radiosurgery (SRS) brain metastases (BM), there an emerging need more precise assessment survival outcomes after SRS. Patients BM and treated by SRS were eligible this study. The primary endpoint was overall (OS). Cox regression models used to identify independent prognostic factors. A predictive nomogram developed evaluated...
Stroke is a rare but fatal complication of advanced cancer with Trousseau syndrome, especially as initial symptoms. Here, we report the clinical characteristics, treatment, and prognosis patients non-small cell lung (NSCLC) who initially presenting acute multiple cerebral infarction.The imaging, oncological outcomes 10 diagnosed syndrome NSCLC between 2015 2021 at Guangdong Sanjiu Brain Hospital were retrospectively collected analyzed. The course two typical cases presented.All...
Objective: To analyze the clinicopathological characteristics and prognosis of diffuse midline glioma (DMG) with H3K27M mutation. Methods: Thirty cases DMG were collected in Guangdong Sanjiu Brain Hospital from October 2016 to May 2018. The patients' data including age, tumor site histological grade, treatment follow-up analyzed. Results: There 21 males 9 females, a mean age 26 years (range 5-53 years). Fourteen tumors located thalamus, 12 brainstem (one involved both thalamus brainstem),...
Abstract: Leptomeningeal metastasis (LM) is a rare but lethal complication of advanced non-small cell lung cancer (NSCLC) that has devastating impact on patient survival and quality life. Osimertinib, an irreversible tyrosine kinase inhibitor, approved as therapy for NSCLC with epidermal growth factor receptor (EGFR) mutation. However, the efficacy optimal dosage osimertinib in treatment patients LM who harbor uncommon EGFR mutations have yet to be fully investigated. Herein, we report case...
Stereotactic radiosurgery (SRS) is a widely used therapy for brain metastases(BMs) in Non-small cell lung cancer(NSCLC). However, its role symptomatic patients with EGFR mutation remains unclear. We have retrospectively reviewed the clinical data of BMs whom received SRS as salvage approach and concurrent gifitinib therapy.Seven primary NSCLC, BMs, were identified retrospective review treated using X-knife at Guangdong 999 Brain Hospital between 1 January 2012 31 August 2014. The median...
We retrospectively studied the efficacy of bevacizumab as salvage therapy for recurrent malignant glioma with a focus on overall survival (OS).Patients who received other than surgery were included. Efficacy was evaluated using MRI. Neurological function Response Assessment in Neuro-Oncology (RANO). The rate calculated Kaplan-Meier method.Fifty-one patients (31 grade III, 20 IV) Among them, 22 subjects (43.1%) bevacizumab. median OS 10.2 months (range, 1 to 27 months). Patients receiving had...
Background: Stereotactic radiosurgery (SRS) is an important treatment option. This report evaluated the efficacy and safety of SRS in patients with large cerebellum metastases from lung cancer.