A5074657995- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- Neurogenetic and Muscular Disorders Research
- Sperm and Testicular Function
- Urologic and reproductive health conditions
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Neuroscience and Neural Engineering
- Medicinal Plant Pharmacodynamics Research
- Heart Rate Variability and Autonomic Control
- Sarcoma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Cardiac Health and Mental Health
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- Cancer Genomics and Diagnostics
- Glutathione Transferases and Polymorphisms
- Geometric Analysis and Curvature Flows
- Histiocytic Disorders and Treatments
- Brain Tumor Detection and Classification
- Transcranial Magnetic Stimulation Studies
- Point processes and geometric inequalities
- Hereditary Neurological Disorders
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Honghu Hospital of Traditional Chinese Medicine
2024
Second Affiliated Hospital of Nanchang University
2021-2024
Nanchang University
2021-2024
Xuzhou Central Hospital
2015-2023
Jiangsu University
2023
Xuzhou Cancer Hospital
2023
Jilin Medical University
2022
Jilin University
2022
Zhongda Hospital Southeast University
2022
Abstract Purpose This paper was mainly conducted to investigate the effect of chronic endometritis (CE) on clinical outcome patients with unexplained infertility. Materials and methods 145 infertility from Reproductive Center our hospital January 2018 December 2021 were selected as group. 42 definite causes control group during same period. Both groups underwent hysteroscopy immunohistochemical tests for CD38 CD138. According results immunohistochemistry, incidence CE between two analyzed....
Abstract Background There is a lack of biomarkers for distinguishing non-obstructive azoospermia (NOA) patients with successful sperm retrieval (Sp+) from those failed (Sp-). This study aimed to determine the potential extracellular vesicles tRNA-derived small RNA (tsRNA) as novel non-invasive biomarker by microdissection testicular extraction (mTESE). Methods The included 18 NOA and 23 (Sp-), 15 obstructive (OA) patients, 5 idiopathic oligospermia (IO) 12 healthy people. Seminal plasma...
Essential tremor (ET) is the most common neurological movement disorder with few treatments and limited therapeutic efficacy, research into noninvasive effective critical. Abnormal cerebello-thalamo-cortical (CTC) loop function are thought to be significant pathogenic causes of ET, cerebellum cortex targets for ET treatment. In recent years, transcranial magnetic stimulation (TMS) has been recognized as a promising brain technique owing its nature safety. this study, we will use left M1...
Amyotrophic lateral sclerosis is an unremitting neurodegenerative (ND) disease characterized by progressive and fatal loss of motor neuron function. While underlying mechanisms for ALS susceptibility are complex, current understanding suggests that interactions between age, genetic, environmental factors may be the key. Environmental exposure to metal/metalloids has been implicated in various ND diseases including ALS, Alzheimer's Disease (AD), Parkinson's (PD). However, most currently...
A plethora of environmental risk factors has been persistently implicated in the pathogenesis amyotrophic lateral sclerosis (ALS), including metal/metalloids. This study aimed to examine potential associations between cerebral spinal fluid (CSF) metal/metalloids and ALS risks. CSF concentrations copper (Cu), nickel (Ni), mercury (Hg), arsenic (As), manganese (Mn), iron (Fe) (spinal- bulbar-onset) patients controls were measured using inductively coupled plasma mass spectrometry (ICP-MS)....
Abstract To comprehensively assess whether p75 ECD in urine could be a candidate biomarker for ALS evaluation. Urine samples were collected from 101 patients, 108 patients with other neurological disease (OND) and 97 healthy controls. 61 followed up clinical data including ALSFRS-r every 6 to 12 months, 23 died 17 lost touch during follow period. Enzyme-linked immunoassay was employed determine concentration. The the severity of ALS. concentration significantly higher than that OND CTRL (p...
Purpose: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive loss of motor neurons, but it increasingly recognized to be more disseminated disease. The literature on the involvement sympathetic skin response (SSR) in ALS few. Methods: We reviewed with specific emphasis SSR and investigated 120 patients sporadic 130 age-matched healthy subjects determine effects patients. was conducted all subjects. Results: found prolonged mean latency patients,...
The brainstem is an important component in the pathology of amyotrophic lateral sclerosis (ALS). Although neuroimaging studies have shown multiple structural changes ALS patients, few investigated alterations brainstem. Herein, we compared structure between patients with and healthy controls.A total 33 controls were recruited this study. T1-weighted diffusion tensor imaging (DTI) acquired on a 3 Tesla magnetic resonance (3T MRI) scanner. Volumetric vertex-wised approaches implemented to...
<b><i>Purpose:</i></b> The diagnosis of Guillain-Barre syndrome (GBS) in the very early stage may be challenging. Our aim was to report neurophysiological abnormalities GBS within 4 days clinical onset. We expected that will diagnosed by assistance study stage. <b><i>Methods:</i></b> prospectively recruited patients with a discharged from First Affiliated Hospital Xi’an Jiaotong University and Xi Jing Hospital. Patients were classified into 3...
The early clinical features of nitrous oxide (N2 O)-induced neuropathy were mimicking that Guillain-Barré syndrome (GBS). We aimed to explore and laboratory characteristics N2 O-induced in comparison with GBS. retrospectively reviewed data 15 patients compared them GBS patients. age the group was significantly younger than (22 ± 5 vs 45 17). Paresthesia more common (100% 53.3%). proportion distal upper limbs weakness lower (20.0% 93.3%). There no significant difference 80.0%). incidence...
To identify differential metabolites and metabolic pathways provide guidance for the novel biomarkers diagnosis prognosis of amyotrophic lateral sclerosis (ALS). ALS patients people without nervous diseases were recruited. Metabolomic analysis was performed using gas chromatography-mass spectrometry (GC/MS). The orthogonal projections to latent structures discriminant (OPLS-DA) used metabolites. Kyoto Encyclopedia Genes Genomes MetaboAnalyst pathways. 75 detected aligned. OPLS-DA showed...
To probe the role of FasL in cell apoptosis oral squamous carcinomas (OSCCs).The expression Fas/FasL was assessed 10 cases normal epithelium, 38 OSCC and tumor infiltrating lymphocytes (TIL), 11 metastatic lymph nodes by immunohistochemistry. Apoptosis cells TIL detected terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL). FasL-induction T tested co-culture vitro with SCC-9 Jurkat cells.The epithelium all demonstrated extensive Fas, positive rate being...
Abstract To explore differential diagnosis value of dissociated lower-limb muscle impairment, we performed a retrospective analysis clinical and electrophysiological features in 141 involved ALS patients, 218 normal controls, 67 disease 32 lumbar spondylosis patients. The impairment was quantified by plantar flexion dorsiflexion strength, compound action potentials ratio peroneal tibial nerves (split index, SI) semi-quantitative scoring scale denervation potential. Clinical features: the...
Abstract The aim of this study was to localize the anatomic distribution upper motor neuron (UMN) loss through examining cortical thickness at clinical onset amyotrophic lateral sclerosis (ALS) and explore manifestation in functionally impaired body region attribute impairment lower (LMN) or UMN mixed LMN UMN? features, corresponding areas from different regions MRI electromyography (EMG) data were collected 108 classical ALS patients. thinner group than control bilateral head-face...
The reference values of long exercise test are inconsistent in previous studies. Our research aims to determine the and improve diagnostic efficiency periodic paralysis.In this study, 100 healthy controls, 35 non-periodic paralysis patients, 47 patients with were recruited. procedures conducted following McMannis(1986) method.The decrease rate compound muscle action potential amplitudes was correlated gender, it not influenced by age, height, weight, exercise. After analyzing receiver...
<b><i>Introduction:</i></b> To illuminate the mechanism of neuromuscular junction involvement by analyzing features a slow-rate repetitive nerve simulation (RNS) and EMG in amyotrophic lateral sclerosis (ALS) patients. <b><i>Methods:</i></b> We retrospectively analyzed relationship between clinical decremental response RNS 184 sporadic ALS <b><i>Results:</i></b> (1) 44.3 43.5% compound muscle action potentials (CMAP)...
<b><i>Objective:</i></b> To investigate the spread direction and prognostic factors in limb-onset sporadic amyotrophic lateral sclerosis (sALS). <b><i>Methods:</i></b> Medical records of 128 patients with sALS were reviewed. Variables studied age at symptom onset, gender, region lateralization onset to diagnosis interval (ODI), progression direction, bulbar-involved, time from ALSFRS-r, upper motor neuron (UMN) signs rate....