A5071024563- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Infectious Diseases and Mycology
- Head and Neck Surgical Oncology
- Antifungal resistance and susceptibility
- Nasal Surgery and Airway Studies
- Olfactory and Sensory Function Studies
- Neuroscience of respiration and sleep
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Sleep and related disorders
- Healthcare and Venom Research
- Sleep and Wakefulness Research
- Antimicrobial Peptides and Activities
- Ginseng Biological Effects and Applications
- Immunotherapy and Immune Responses
- Congenital Ear and Nasal Anomalies
- Bone Tumor Diagnosis and Treatments
- Airway Management and Intubation Techniques
- Mycobacterium research and diagnosis
- Drug-Induced Adverse Reactions
- Protein Degradation and Inhibitors
Gwangju Institute of Science and Technology
2018-2025
Catholic University of Daegu
2015-2024
Kangwon National University
2023
Daegu Health College
2023
Daegu Catholic University Medical Center
2021
Mayo Clinic
2004-2005
Catholic University of America
2003
Kyungpook National University
2000
Abstract Eosinophils and their products are probably important in the pathophysiology of allergic diseases, such as bronchial asthma, host immunity to certain organisms. An association between environmental fungal exposure asthma has been long recognized clinically. Although microorganisms (e.g., lipopolysaccharides) directly activate inflammatory cells macrophages), mechanism(s) that triggers eosinophil degranulation is unknown. In this study we investigated whether human eosinophils have...
The management of type 2 diabetes mellitus (T2DM) is generally not only focused on pharmacological therapy. Medical nutrition therapy often forgotten by patients for several reasons, such as difficulty determining the right nutritional pattern themselves, regulating their daily patterns, or even heeding diet recommendations given doctors. Management one important efforts that can be made diabetic to prevent an increase in complexity disease. Setting a with proper will help manage healthy...
Chronic rhinosinusitis with nasal polyps (CRSwNP) has various histological patterns and the immunologic characteristics differ between eastern western patients. This study assessed pattern of Korean NPs determined whether NP have become westernized.Three hundred forty-nine CRSwNP patients were enrolled in this 2001 (n = 107), 2006 111), 2011 131). Histological type was categorized as eosinophilic, neutrophilic, seromucinous gland hyperplasia, stromal atypia types. Medical records reviewed...
Conclusions. Proteases in fungi interact with nasal epithelial cells and enhance the production of inflammatory cytokines vitro. These induced migration eosinophils neutrophils. Protease-activated receptors (PARs) might also play a role process cell activation. Objective. The epithelium is first barrier encountered by airborne allergens an active participant airway inflammation. Fungi have been increasingly recognized as important pathogens sinusitis consist several allergenic proteins....
Melittin and apamin are the main components of bee venom they have been known to anti-inflammatory anti-fibrotic properties. The aim this study was evaluate effect melittin on airborne fungi-induced chemical mediator extracellular matrix (ECM) production in nasal fibroblasts. Primary fibroblasts were isolated from polyps, which collected during endoscopic sinus surgery. Nasal treated with Alternaria Aspergillus. effects interleukin (IL)-6 IL-8 determined enzyme linked immunosorbent assay....
<i>Background:</i> The nasal epithelium is the first barrier encountered by airborne allergens and an active participant in airway inflammation. Fungi have been increasingly recognized as important pathogens sinusitis diseases. aim of study was to evaluate fungal protease activity during cytokine production polyp epithelial cells determine expression Toll-like receptor (TLR) mRNA fungi. <i>Methods:</i> Nasal were obtained from patients stimulated with...
Mitochondria-specific delivery methods offer a valuable tool for studying mitochondria-related diseases and provide breakthroughs in therapeutic development. Although several small-molecule peptide-based transporters have been developed, peptoids, proteolysis-resistant peptidomimetics, are promising alternative to current approaches. We designed series of amphipathic peptoids evaluated their cellular uptake mitochondrial localization. Two with cyclohexyl residues demonstrated highly...
Cluster analyses on inflammatory markers of chronic rhinosinusitis (CRS) in Asians from multicenter data are lacking. This study aimed to identify the endotypes CRS Koreans and evaluate relationship between clinical parameters.Nasal tissues were obtained patients with controls who underwent surgery. The investigated by measuring interleukin (IL)-5, interferon (IFN)-γ, IL-17A, IL-22, IL-1β, IL-6, IL-8, matrix metalloproteinase-9, eotaxin-3, eosinophil cationic protein, myeloperoxidase (MPO),...
Silver has long been known as a strong antimicrobial and disinfectant. Several types of nano-silver coated products have developed. However, the disinfectant characteristics not well studied. The aim this study was to investigate effect on allergic inflammation in mouse model.Female BALB/C mice were sensitized by intraperitoneal injection ovalbumin (OVA) aluminium hydroxide days 0, 7, 14, 21. Mice challenged with intranasal instillation OVA. Nano-silver also administered nasally prior...
Abstract Objectives/Hypothesis Nasal polyps develop in the ethmoidal and middle turbinate area, often relation to inflammatory conditions. Their exact etiology pathogenesis are still under debate. Histologically, infiltrated by a number of cells, with eosinophil predominating most specimens. This finding suggests that nasal polyp is an growth controlled local environment. The chemokines eotaxin RANTES ( r egulated on ctivation n ormal T cell e xpressed s ecreted) have been postulated be...
Abstract Objectives/Hypothesis Eosinophil infiltration into an inflammatory site is a characteristic histological finding in patients with chronic rhinosinusitis and nasal polyps. Most of the eosinophils are activated cavity, but exact activation mechanism unknown. The study was designed to investigate effect human epithelial cells on eosinophils. Study Design Peripheral blood were isolated from healthy volunteers incubated polyp cell conditioned media (HPECM). Superoxide production...
The role of fungi in the pathogenesis chronic rhinosinusitis (CRS) is being increasingly recognized. presences fungal spores are a necessary condition for sinusitis, and spore counts vary widely, both geographically seasonally. aim this study was to characterize seasonal variation nasal cavity CRS patients compare it with histologic types polyps.One hundred eight clinical diagnosis polyps were enrolled 1 year. Nasal secretions obtained by aspiration cultured identify fungi. divided into four...
Background Asian sand dust (ASD) contains a variety of chemical and microbiological materials such as lipopolysaccharide (LPS) beta-glucan that can cause inflammation. The increase in the atmospheric concentration ASD has been associated with asthma severity adverse effects on respiratory function. aim this study was to evaluate effect inflammatory process mucin gene expression nasal epithelial cells. Methods Primary polyp cells were exposed for 72 hours, then supernatants collected. To...
Bee venom (BV) has been used as an anti-inflammatory and immune modulating agent in Oriental medicine. This study a mouse model to investigate the anti-allergic effect of BV, which is treatment various inflammatory diseases traditional BV was obtained from National Institute Agricultural Science Technology Korea. Female BALB/C mice were sensitized by intraperitoneal injection ovalbumin (OVA). administered nasally prior intranasal instillation OVA. Allergic behavior, serum OVA-specific...
Objective—Although chronic rhinosinusitis (CRS) is one of the most frequently reported diseases its etiology not well understood. Recently, fungi have been proposed to influence chronicity rhinosinusitis. If do play an important role then topical antifungal treatment may improve inflammatory process CRS. Therefore, in this study we measured cytokine levels nasal polyps after intranasal irrigation. Material and Methods—Nasal were collected before 4 weeks with 100 mg/l amphotericin B (n=16),...