A5100337646- Plant biochemistry and biosynthesis
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Genomic variations and chromosomal abnormalities
- Transgenic Plants and Applications
- Cancer Genomics and Diagnostics
- Genomics and Rare Diseases
- Caveolin-1 and cellular processes
- Fibroblast Growth Factor Research
- Dermatologic Treatments and Research
- Genetic Mapping and Diversity in Plants and Animals
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- Kruppel-like factors research
- Biochemical Acid Research Studies
- Cell Adhesion Molecules Research
- Sphingolipid Metabolism and Signaling
- Mesenchymal stem cell research
- Inflammatory Myopathies and Dermatomyositis
- Connective tissue disorders research
- Dermatological and Skeletal Disorders
- Protein Kinase Regulation and GTPase Signaling
- Body Contouring and Surgery
- Aortic Disease and Treatment Approaches
- High Altitude and Hypoxia
Shanghai Jiao Tong University
2017-2024
XinHua Hospital
2022
Renji Hospital
2022
Shanghai Children's Medical Center
2020-2021
The First Affiliated Hospital, Sun Yat-sen University
2020
Zhongshan Hospital
2020
Fudan University
2020
Sun Yat-sen University
2019-2020
Peking University People's Hospital
2020
Peking University
2020
Artemisia annua, a traditional Chinese medicinal plant, remains the only plant source for artemisinin production, yet few genes have been identified to be involved in both response biotic stresses, such as pathogens, and biosynthesis. Here, we isolated WRKY transcription factor (TF) AaWRKY17, which could significantly increase content resistance Pseudomonas syringae A. annua. Yeast one-hybrid (Y1H), dual-luciferase (dual-LUC), electrophoretic mobility shift assay (EMSA) results showed that...
Artemisinin is a secondary metabolite extracted from Artemisia annua. As an effective antimalarial component certified by WHO, artemisinin has extensive economical values. Numerous studies about transcription factors positively regulating biosynthesis have been published while negative regulators are rarely reported. In the present study, we identified AaMYB15 as first R2R3-MYB that negatively regulates in A. Experimental evidences showed factor within nucleus and predominantly expressed...
The Agrobacterium-mediated transient transformation, which proved effective in diverse plant species, has been widely applied for high-throughput gene function studies due to its simplicity, rapidity, and high efficiency. Despite the efforts have made on Artemisia annua expression, achieving functional characterization basing a fast easy-manipulated transformation system A. remains challenging.The first pair of true leaves is an ideal candidate Agrobacterium injection. EHA105 was optimal...
Abstract Diabetic patients are prone to developing chronic inflammation after trauma and have persistent nonhealing wounds. Reactive oxygen species (ROS) recurrent bacterial infections at the site of long‐term wounds also further delay skin wound healing tissue regeneration. In this study, a granular gel (which exhibits ROS scavenging antibacterial properties) is fabricated based on hyaluronic acid‐ g ‐lipoic acid (HA‐LA). Briefly, HA‐LA synthesized fabricate microgels, which assembled by Ag...
Hyperbaric oxygen preconditioning (HBO₂P + HAE) has been found to be beneficial in preventing the occurrence of ischemic damage brain, spinal cord, heart, and liver several disease models. In addition, pulmonary inflammation edema are associated with a marked reduction expression levels both aquaporin (AQP) 1 AQP5 lung. Here, aims this study first ascertain whether acute lung injury can induced by simulated high altitude rats second assess HBO2P HAE is able prevent proposed altitude-induced...
Indigenous pigs in South China are valuable genetic resources with many specific and unique characters, which have played an important role the establishment of some western modern pig breeds. However, origin diversity indigenous not been fully understood. In present study, we sequenced 534 novel mitochondrial DNA (mtDNA) D-loop assembled 54 complete mitogenome sequences for all 17 breeds from Fujian, Guangdong, Guangxi Hainan China. These data were analyzed together previously published...
Abstract Background Pathogenic variants in POC1A led to SOFT syndrome and variant POC1A-related (vPOC1A) syndrome. is a rare primordial dwarfism condition characterized by short stature, onychodysplasia, facial dysmorphism hypotrichosis.The main clinical differences between vPOC1A include dyslipidemia with insulin resistance acanthosis nigricans. To our knowledge, this the first report of patient diagnosed homozygous splicing variant, which could help extend understanding genotypic...
Abstract Background Tricho‐rhino‐phalangeal syndrome (TRPS) is a rare autosomal dominant disorder characterized by craniofacial and skeletal malformations including short stature, thin scalp hair, sparse lateral eyebrows, pear‐shaped nose, cone‐shaped epiphyses. This condition caused haploinsufficiency or dominant‐negative effect of the TRPS1 gene. Methods In this study, we analyzed clinical genetic data five unrelated TRPS patients. They were suspected having on basis radiological features...
Abstract Epithelial ovarian cancer (EOC) is the leading cause of deaths due to in women. Adipocytes have been suggested play a key role stimulation EOC growth. However, mechanisms underlying adipocyte-induced proliferation remain undefined. Here, we provide first evidence that adipocytes induce activation sphingosine kinase (SphK) 2 EOC, which represents novel pathway mediates SphK2 inhibition cells led remarkable cell proliferation. Moreover, was extracellular signal-regulated protein...
Understanding the molecular mechanisms underlying human adipose-derived stem cell (hASC) differentiation to smooth muscle may contribute development of effective therapies for relevant defects, such as bladder wall and urethral defects. A previous study described hASCs cells (SMCs) by transforming growth factor-β1 (TGF-β1) bone morphogenetic protein‑4 (BMP4) treatment. The present investigated whether microRNA-145 (miR‑145) be involved in process hASC differentiation. expression miR‑145 was...
To the Editor: A 50-year-old man presented with a 1-month history of pruritic papules and nodules on his trunk extremities. The patient had 20-year alcoholism, 10-year Meniere's disease. He was treated intravenous sodium aescinate for 5 days because disease 2 months ago. Other chronic diseases or special family histories were denied. Upon physical examination, red brown papules, diameter 3 to mm noted limbs, shoulders, dorsum, central umbilicated necrosis, keratin plug, accompanied by Kobner...
ABSTRACT Multiple synostoses syndromes (SYNS) are a group of rare genetic bone disorders characterized by multiple joint fusions. We previously reported an SYNS4-causing GDF6 c.1330 T > A (p.Tyr444Asn) mutation, which reduced Noggin-induced inhibition and enhanced SMAD1/5/8 signaling. However, the mechanisms gain-of-function mutation alters formation comprehensive molecular portraits SYNS4 remain unclear. Herein, we introduce p.Tyr443Asn (orthologous to human p.Tyr444Asn) into mouse...
Trichomes, which are classified as glandular or non-glandular, hair-like epidermal structures that present on aerial parts of most plant species. Glandular secretory trichomes (GSTs) have the capacity to secrete and store specialized metabolites, widely used natural pesticides, food additives, fragrance ingredients pharmaceuticals. Isolating individual is an essential way for identifying trichome-specific gene functions discovering novel metabolites. However, isolation difficult...
Background: Post-transcriptional mechanisms, including microRNA-mediated inhibition of gene expression, participates in vascular remodeling by modulating the biological functions VSMCs.Methods: We explored miR-22 expression aortic tissues from normal and thoracic dissection patients respectively. In addition, we noticed that apoptosis VSMCs was regulated vitro, vivo models.Findings: The AD is lower than NA (P < 0.05). Apoptosis accelerates human aorta with dissection. meanwhile,...