A5100374347- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Peripheral Artery Disease Management
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Pancreatitis Pathology and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lipoproteins and Cardiovascular Health
- Cardiovascular Effects of Exercise
- Acute Ischemic Stroke Management
- Intensive Care Unit Cognitive Disorders
- Viral Infections and Immunology Research
- Cardiac and Coronary Surgery Techniques
- Vascular Procedures and Complications
- Cardiac electrophysiology and arrhythmias
- Diabetes and associated disorders
- Eosinophilic Disorders and Syndromes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Persona Design and Applications
- Hemophilia Treatment and Research
- Radiation Dose and Imaging
National Central University
2024
National Yang Ming Chiao Tung University
2017-2024
Taichung Veterans General Hospital
2014-2024
National Chung Hsing University
2022-2024
National Taiwan University Hospital
2024
Landseed Hospital
2014-2024
National Taipei University
2017-2022
Taipei Medical University-Shuang Ho Hospital
2022
Taipei Medical University
2022
Wuhan Polytechnic University
2018
Abstract Background and Aim This study estimated the prevalence of metabolic dysfunction‐associated steatotic liver disease (MASLD) according to cardiometabolic risk factors. The long‐term impacts MASLD on all‐cause cardiometabolic‐specific mortality were evaluated. Methods We enrolled 343 816 adults aged ≥30 years who participated in a health screening program from 1997 through 2013. was identified basis abdominal ultrasonography profiles. participants further categorized by enzyme...
Two oligomeric types of glycyl-tRNA synthetase (GlyRS) are found in nature: a α2 type and α2β2 type. The former has been identified all three kingdoms life often pairs with tRNAGly that carries an A73 discriminator base, while the latter is only bacteria chloroplasts almost always coupled contains U73. In yeast Saccharomyces cerevisiae, single GlyRS gene, GRS1, provides both cytoplasmic mitochondrial functions, isoacceptors compartments possess A73. We showed herein Homo sapiens Arabidopsis...
Heavy calcifications remain formidable challenges to PCI, even for well-experienced operators. However, rotational atherectomy (RA)-induced coronary perforations (CPs) still could not be obviated. This study was explore incidence and mechanisms of RA-induced CP in real-world practice. Knowing why CPs occur RA should help operators avert such mishaps.Patients who received from April 2010 December 2019 with keywords related were retrieved database. The procedure details, angiography, clinical...
Approximately 25%-30% of patients diagnosed with idiopathic pulmonary arterial hypertension (PAH) have a clustered underlying Mendelian genetic cause and should be classified as heritable PAH (HPAH). The sixth World Symposium on Pulmonary Hypertension listed
Objectives To evaluate the outcomes of rotational atherectomy for heavily‐calcified side branches coronary bifurcation lesions. Background Side‐branch (SB) preservation is clinically important but technically challenging in non‐left main true SB (SB RA) sometimes mandatory clinical are not well studied. Methods We retrospectively studied patients who underwent RA at our institute heavily calcified, balloon‐uncrossable or—undilatable lesions over an approximately 5‐year period (January 2011...
Introduction A high hemoglobin glycation index (HGI) and glycated (HbA1c) level are associated with greater inflammatory status, dipeptidyl peptidase-4 (DPP-4) inhibitors can suppress inflammation. We aimed to evaluate the relationship between HGI therapeutic effect of DPP-4 inhibitors. Methods This retrospective cohort study followed 468 patients type 2 diabetes receiving inhibitor treatment for 1 year. Estimated HbA1c was calculated using a linear regression equation derived from another...
To investigate the effects of statins on all-cause mortality risk at different low-density lipoprotein cholesterol (LDL-C) levels, and to compare between statin users non-users with identical LDL-C levels in a type 2 diabetes cohort.In total, 10,582 outpatients aged ≥18 years mellitus (T2DM) 2009 2012 were enrolled this retrospective cohort study central Taiwan. All-cause events followed up until end 2014. According medical records during follow-up period, patients classified into (+) (-)...
Abstract The purpose of this phase I clinical trial is to assess the safety and tolerability allogeneic adipose tissue‐derived stem cells (ADSCs) among chronic kidney disease (CKD) patients. 12 eligible CKD patients with an estimated glomerular filtration rate (eGFR) 15–44 ml/min/1.73 m 2 received one dose intravenous ADSCs (ELIXCYTE ® ), as 3 groups: low (6.4 × 10 7 in total 8 ml), middle (19.2 24 ml) 6 high (32.0 40 ELIXCYTE evaluated after 48 weeks. Primary endpoint was profiles terms...
Genetic variants could be identified in subjects with idiopathic and heritable pulmonary arterial hypertension (PAH). The 6th World Symposium on Pulmonary Hypertension (WSPH) provided a list of genes evidence association PAH. However, reports using whole exome sequencing (WES) from southeastern Asian PAH cohorts were scarce.Subjects (N = 45) two medical centers central Taiwan screened for related gene variants. genomic DNA was prepared peripheral blood lymphocytes. We performed WES all...
Rotational atherectomy (RA) is an indispensable tool used for calcified lesion preparation in percutaneous coronary intervention (PCI). However, use of RA the setting acute myocardial infarction (AMI) challenged with limited clinical data.
Asians have higher frequency of intracranial arterial stenosis. The present study aimed to compare the clinical features and outcomes ischemic stroke patients with without middle cerebral artery (MCA) stenosis, assessed by transcranial sonography (TCS), based on Taiwan Stroke Registry (TSR).Patients acute or transient attack registered in TSR, received both carotid duplex TCS assessment were categorized into those stenosis (≥50%) (<50%) extracranial internal (ICA) MCA, respectively. Logistic...
Folic acid is a necessary micronutrient for normal human growth and development. Benzo(a)pyrene (BaP) ubiquitously distributed environmental pollutant its metabolite, benzo(a)pyrene-diol-epoxide, known to exert strong teratogenic carcinogenic effect on the body’s tissues cells. The aim of this study was investigate mechanism by which folic can inhibit toxic effects BaP both in vivo vitro . We measured changes 16HBE cell activity affected intervention using counting kit-8 assay that cycle...
Abstract A number of studies have reported on treatment outcomes coronary stenting (PCI) for multivessel artery diseases (MVD), and compared them with the conventional bypass grafting (CABG). However, clinical robot-assisted CABG (R-CABG) in comparison PCI MVD patients not been investigated. We recruited retrospectively receiving R-CABG drug-eluting stents all vessels one stage between January 2005 December 2013 at our institution least 3 years were analyzed. total 638 studied. Among them,...
The use of Complex and High-risk Coronary Interventions (CHIPs) has increased in recent years. Both rotational atherectomy (RA) hemodynamic support are important parts CHIPs.
For idiopathic pulmonary artery hypertension (PAH) patients with end-stage right heart failure who received maximal medical therapy, balloon atrial septostomy (BAS) is recommended by most guidelines as a palliative therapy or bridging treatment before lung transplantation. In this report, we described 32-year-old woman PAH, PAH-specific treatment, including intravenous prostacyclin, but still suffered from refractory failure. The markedly enlarged atrium (RA), high mean RA pressure of 23...
Objective. Patients with advanced renal insufficiency are at high risk of coronary artery disease (CAD) and complex lesions. Treating calcified lesion rotational atherectomy (RA) in these patients might be associated higher risks poorer outcomes. This study was set to evaluate features outcomes RA patients. Method. Consecutive who received from April 2010 2018 were queried the Cath Lab database. The procedural details, angiography, clinical information reviewed detail. Results. A total 411...
Purpose: Clopidogrel is widely used in coronary artery, peripheral arterial, and cerebrovascular disease. We aimed to study the association of CYP2C19 phenotype with cardiovascular outcomes interventional procedures a hospital-based population. Patients Methods: This cross-sectional, retrospective enrolled patients prior exposure clopidogrel at Taichung Veterans General Hospital (TCVGH) using data extracted from Taiwan Precision Medicine Initiative (TPMI). Data on phenotype,...
CYP2C19 loss-of-function (LOF) alleles reduce the effectiveness of clopidogrel and are associated with high rates clinical events in patients undergoing percutaneous coronary intervention (PCI) stenting Northeast Asians. However, prevalence influence LOF Southeast Asians remain unclear.This study aims to retrospectively investigate outcomes East Asian taking PCI.Between June 2019 2020, volunteer participants a single medical center were consecutively selected. The genetic data derived from...
as decrease ≥10-20 ms in iQRSd after CRT) on ventricular arrhythmia are controversial. 2In contrast, MRR is associated with significantly improved clinical outcomes. 3The anti-arrhythmic effect of only (only mechanical reverse remodeling) patients moderate-severe HF, however, still 4,5We recently found that both ERR and (ERR+MRR) CRT had more protective effects than only. 6-8It therefore clinically important to predict C ardiac resynchronization therapy (CRT) the standard treatment for heart...
Eosinophilic myocarditis encompasses a variety of etiologies and the prognosis varies. For patients with hypersensitive response to medications, high-dose corticosteroids discontinuation culprit medications are main treatments. We reported young man biopsy-proven eosinophilic which was possibly induced by Chinese herbal medicine. His heart failure left ventricular hypertrophy improved soon after low-dose corticosteroid. Low-dose corticosteroid may be effective in selected myocarditis. Early...
Current predictive models for patients undergoing coronary angiography have complex parameters which limit their clinical application. Coronary catheterization reports that describe lesions and the corresponding interventions provide information of severity artery disease completeness revascularization. This is relevant predicting patient prognosis. However, no model has been constructed using text content from before.To develop a deep learning to predict 5-year all-cause mortality...
BackgroundDemographics of pulmonary hypertension (PH) has changed a lot over the past forty years. Several recent registries noted an increase in mean age PH but only few them investigated characteristics elderly patients. Thus, we aimed to analyze such population this study.MethodsThis multicenter study enrolled patients diagnosed with group 1, 3, 4, and 5 consecutively from January 2019 December 31, 2020. A total 490 was included, were divided into three groups by (≤45 years, 45–65 >65...