A5047638206- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Cancer therapeutics and mechanisms
- Hematopoietic Stem Cell Transplantation
- Extracellular vesicles in disease
- Protein Degradation and Inhibitors
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Misinformation and Its Impacts
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Synthetic Organic Chemistry Methods
- Retinoids in leukemia and cellular processes
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Childhood Cancer Survivors' Quality of Life
- Phagocytosis and Immune Regulation
- Mesenchymal stem cell research
- Telomeres, Telomerase, and Senescence
- Hydrogen's biological and therapeutic effects
- Bone and Joint Diseases
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
Albert Einstein College of Medicine
2019-2024
Montefiore Health System
2024
Montefiore Medical Center
2019-2024
Montefiore Einstein Comprehensive Cancer Center
2024
University of Brescia
2021-2022
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2021
Stem Cell Institute
2019
California Institute for Regenerative Medicine
2019
Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within lineage, HSCs have largest NADPH pools, are required proper and homeostasis. Bioinformatic analysis of transcriptome, biochemical assays, genetic inactivation FAO all indicate FAO-generated fuels cholesterol synthesis in HSCs. Interference with disturbs segregation toward...
Abstract Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but bases for its transforming properties and overall association with favorable therapeutic responses remain incompletely understood. Here we demonstrate that an oncogenic mutant form of (NPM1c) impairs mitochondrial function. NPM1c also hampers formation promyelocytic (PML) nuclear bodies (NB), which are regulators fitness key senescence effectors. Actinomycin D (ActD), antibiotic...
The role of mitochondria in the fate determination hematopoietic stem and progenitor cells (HSPCs) is not solely limited to switch from glycolysis oxidative phosphorylation, but also involves alterations mitochondrial features properties, including membrane potential (ΔΨmt). HSPCs have a high ΔΨmt even when rates respiration phosphorylation are low, we previously shown that minimum proton flow through ATP synthesis (or complex V) enables HSPCs. Here show sustain unique equilibrium between...
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy that continues to have poor prognosis despite recent therapeutic advances. Venetoclax (Ven), a BCL2-inhibitor has shown high response rate in AML; however, relapse invariable due mitochondrial dysregulation includes upregulation of the antiapoptotic protein MCL1, central mechanism Ven resistance (Ven-res). We previously demonstrated transcription factor STAT3 upregulated AML hematopoietic stem and progenitor cells (HSPCs)...
There are scarce data regarding influenza vaccination among people with HIV infection (PWHIV). The goal of this explorative study is to assess hesitancy toward in a group PWHIV during the COVID-19 pandemic. A questionnaire was administered 219 patients vaccinated at our clinic 2020-2021 campaign. It evaluated subjects' adherence vaccine over last three seasonal campaigns, confidence, complacency and convenience, effect pandemic on choice become vaccinated. population divided into two groups:...
As cellular metabolism is a key regulator of hematopoietic stem cell (HSC) self-renewal, the various roles played by mitochondria in homeostasis have been extensively studied HSC researchers. Mitochondrial activity levels are reflected their membrane potentials (ΔΨm), which can be measured cell-permeant cationic dyes such as TMRM (tetramethylrhodamine, methyl ester). The ability efflux pumps to extrude these from cells limit usefulness, however. resulting measurement bias particularly...
High-risk MDS & AML are the result of malignant transformation an immature hematopoietic precursor. Venetoclax (Ven) is a selective inhibitor anti-apoptotic BCL2 protein that FDA approved for treatment AML, despite which, overall cure rates in HR-MDS and dismal. Signal transducer activator transcription 3 (STAT3) de-methylation overexpression stem cells. It associated with adverse prognosis large cohort patients. We have also demonstrated STAT3 controls several important leukemic drivers...
Radiation therapy is employed in treating various cancer types. However, depending on the type and stage of cancer, its benefits can be limited, it may cause serious side effects that detrimentally affect quality life (QOL) for patient. Preventing radiation enhance response to treatment improve patient’s QOL. Independently, vitamin C hydrogen have demonstrated potential reducing anticancer drugs therapy. Furthermore, both been postulated possess direct properties. their combined remain...
There are scarce data regarding flu vaccination among people with HIV infection (PWHIV). The goal of this explorative study is to assess hesitancy toward influenza in a group PWHIV during the pandemic. A questionnaire was administered 219 patients vaccinated at our clinic 2020-2021 campaign. It evaluated subjects’ adherence over last 3 seasonal campaigns, vaccine confidence, complacency and convenience, effect pandemic on choice vaccinate. population divided into two groups: fully...
<p>Key resource table with RRID</p>
<p>Supplementary table S1</p>
<p>Supplementary figures and methods</p>
<p>Key resource table with RRID</p>
<div>Abstract<p>Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but bases for its transforming properties and overall association with favorable therapeutic responses remain incompletely understood. Here we demonstrate that an oncogenic mutant form of (NPM1c) impairs mitochondrial function. NPM1c also hampers formation promyelocytic (PML) nuclear bodies (NB), which are regulators fitness key senescence effectors. Actinomycin D...
<p>Supplementary table S2</p>
<p>Supplementary table S2</p>
<p>Supplementary table S3</p>
<p>Supplementary table S3</p>