A5071665974- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Genetic Associations and Epidemiology
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Advanced Steganography and Watermarking Techniques
- Cardiovascular Issues in Pregnancy
- Autoimmune and Inflammatory Disorders Research
- Cardiac Structural Anomalies and Repair
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Vasculitis and related conditions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Chemokine receptors and signaling
- Moyamoya disease diagnosis and treatment
- Connective tissue disorders research
- Blind Source Separation Techniques
- RNA regulation and disease
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Acute Myeloid Leukemia Research
- Immune Response and Inflammation
University of Ulsan
2015-2024
Ulsan College
2015-2024
Asan Medical Center
2015-2024
Chung-Ang University Hospital
2018
Kyung Hee University Hospital at Gangdong
2018
Catholic University of Korea
2018
Korea National Institute of Health
2003-2007
GTx (United States)
2007
National Human Genome Research Institute
2006
National Institutes of Health
2002-2005
Summary Unraveling the genetic background of common complex traits is a major goal in modern genetics. In recent years, genome‐wide association (GWA) studies have been conducted with large‐scale data sets variants. Most those relied on single‐marker approaches that identify single factors individually and can be limited considering fully joint effects multiple traits. Joint identification would more powerful provide better prediction since it utilizes combined information across Here we...
Abstract Mice bearing the experimental murine renal cancer Renca can be successfully treated with some forms of immunotherapy. In present study, we have investigated molecular pathways used by NK and T cells to lyse cells. normally express low levels Fas that substantially enhanced either IFN-γ or TNF-α, combination + TNF-α synergistically enhances cell-surface expression. addition, pretreated are sensitive lysis mediated ligand (FasL)-expressing hybridomas (dllS), cross-linking anti-Fas Abs...
The role of Fas in the regulation solid tumor growth was investigated. Murine renal carcinoma (Renca) cells were constitutively resistant to Fas-mediated killing vitro, but exhibited increased expression and sensitivity after exposure IFN-gamma TNF. Transfected Renca overexpressing efficiently killed vitro upon anti-Fas Ab (Jo2). When Fas-overexpressing injected into syngenic BALB/c mice, there a consistent significant delay progression, reduced metastasis, prolonged survival that not...
Abstract IFN-γ is a critical component of the endogenous and many cytokine-induced antitumor immune responses. In this study we have shown that combination IL-18 IL-2 (IL-18/IL-2) synergistically enhances production both in vitro vivo, synergizes vivo to induce complete durable regression well-established 3LL tumors >80% treated mice. We observed nascent, but ineffective, host response against depends on IL-12 Fas/Fas ligand (Fas-L) pathway. The combined administration IL-18/IL-2...
Early detection and proper management of kidney rejection are crucial for the long-term health a transplant recipient. Recipients normally monitored by serum creatinine measurement sometimes with graft biopsies. Donor-derived cell-free deoxyribonucleic acid (cfDNA) in recipient's plasma and/or urine may be better indicator acute rejection. We evaluated digital PCR (dPCR) as system monitoring status using single nucleotide polymorphism (SNP)-based donor DNA or urine. compared abilities QX200,...
Kawasaki disease (KD) is an acute systemic vasculitis that can potentially cause coronary artery aneurysms in some children. KD occurs approximately 1.5 times more frequently males than females. To identify sex-specific genetic variants are involved pathogenesis children, we performed a sex-stratified genome-wide association study (GWAS), using the Illumina HumanOmni1-Quad BeadChip data (249 cases and 1,000 controls) replication for 34 candidate SNPs independent sample set (671 3,553...
Recently, the medical image has been digitized by development of computer science and digitization devices. There are needs for database service long term storage because construction PACS (picture archiving communication system) following DICOM (digital imaging communications in medicine) standards, tele-medicine, et al. Furthermore, authentication copyright protection required to protect illegal distortion reproduction information data. In this paper, we propose digital watermarking...
Cancer diagnosis is associated with an increased suicide risk, particularly within the first 1 year after of cancer. Abnormal function hypothalamic-pituitary-adrenal axis has been implicated in pathophysiology depression and suicide. We examined genetic associations functional Bcl-1 polymorphism (rs41423247) neuron-specific glucocorticoid receptor (NR3C1) gene, death by cancer patients. Suicides occurring a ('early suicide') were considered separately from those suicides during second or...