A5059114632- COVID-19 epidemiological studies
- Parasites and Host Interactions
- Data-Driven Disease Surveillance
- Fungal Infections and Studies
- Viral Infections and Vectors
- Plant Pathogens and Resistance
- Birth, Development, and Health
- Fecal contamination and water quality
- Global Health and Epidemiology
- Viral gastroenteritis research and epidemiology
- Child Nutrition and Water Access
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Climate Change and Health Impacts
- Retinal and Optic Conditions
- Viral Infections and Immunology Research
- COVID-19 and Mental Health
- Insects and Parasite Interactions
- Census and Population Estimation
- Global Maternal and Child Health
- Parasite Biology and Host Interactions
- Epigenetics and DNA Methylation
- Malaria Research and Control
- Flood Risk Assessment and Management
- Hidradenitis Suppurativa and Treatments
University of California, Berkeley
2016-2025
Santa Clara County Behavioral Health Services
2024
University of California System
2023
Berkeley Public Health Division
2017
Emory University
2015
Importance A SARS-CoV-2 vaccine was approved for adolescents aged 12 to 15 years on May 10, 2021, with approval younger age groups following thereafter. The population level impact of the pediatric COVID-19 vaccination program has not yet been established. Objective To identify whether California's immunization associated changes in incidence and hospitalizations. Design, Setting, Participants case series including children 6 months conducted California. Data were obtained cases California...
Coccidioidomycosis, caused by inhalation of Coccidioides spp. spores, is an emerging infectious disease that increasing in incidence throughout the southwestern US. The pathogen soil-dwelling, and spore dispersal human exposure are thought to co-occur with airborne mineral dust exposures, yet fundamental exposure-response relationships have not been conclusively estimated. We estimated associations between fine concentration coccidioidomycosis California from 2000 2017 at census tract level,...
Dams have long been associated with elevated burdens of human schistosomiasis, but how dams increase disease is not always clear, in part because many ecological and socio-economic effects. A recent hypothesis argues that block reproduction the migratory river prawns eat snail hosts schistosomiasis. In Senegal River Basin, there evidence prawn populations declined schistosomiasis increased after completion Diama Dam. Restoring to a water-access site upstream dam reduced density reinfection...
Coccidioidomycosis, an emerging fungal disease in the western USA, exhibits seasonal patterns that are poorly understood, including periods of strong cyclicity, aseasonal intervals, and variation timing have been minimally characterized, unexplained as to their causal factors. Coccidioidomycosis incidence has increased markedly recent years, our limited understanding intra- inter-annual seasonality hindered identification important drivers transmission, climate conditions. In this study, we...
As the appreciation for importance of environment in infectious disease transmission has grown, so too interest pathogen fate and transport. Fate been traditionally described by simple exponential decay, but there is increasing recognition that some pathogens demonstrate a biphasic pattern decay-fast followed slow. While many have attributed this behavior to population heterogeneity, we dynamics can arise through number plausible mechanisms. We examine identifiability general model...
Abstract Background Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), associated with severe manifestations the disease. Pediatric immunization inactivated EV71 vaccine was initiated in 2016 Asia-Pacific region, including China. We analyzed time series HFMD cases attributable to EV71, coxsackievirus A16 (CA16), other enteroviruses Chengdu, transmission center China, assess early impacts immunization. Methods Reported were obtained from China’s...
Background Large-scale school closures have been implemented worldwide to curb the spread of COVID-19. However, impact and re-opening on epidemic dynamics remains unclear. Methods We simulated COVID-19 transmission using an individual-based stochastic model, incorporating social-contact data school-aged children during shelter-in-place orders derived from Bay Area (California) household surveys. under observed conditions counterfactual intervention scenarios between March 17-June 1,...
Significance Food system collapse incurs major societal costs that may extend across generations. The Great Chinese Famine—widely acknowledged as the largest famine in human history—was associated with tremendous short-term adverse health consequences, yet its long-term effect on infectious disease incidence has not been estimated. We conducted a cohort analysis of >1 million pulmonary tuberculosis (PTB) cases center ongoing transmission experienced high mortality, finding substantial...
School closures may reduce the size of social networks among children, potentially limiting infectious disease transmission. To estimate impact K–12 and reopening policies on children's interactions COVID-19 incidence in California's Bay Area, we collected data contacts assessed implications for transmission using an individual-based model. Elementary Hispanic children had more during than high school non-Hispanic respectively. We estimated that spring 2020 elementary schools averted 2167...
Coccidioidomycosis, an emerging fungal disease in the southwestern United States, exhibits pronounced seasonal transmission, yet influence of current and future climate on timing duration transmission seasons remains poorly understood. We developed a distributed-lag Markov state transition model to estimate effects temperature precipitation season onset end, analysing reported coccidioidomycosis cases ( n = 72 125) California from 2000 2023. Using G-computation substitution estimators, we...
Objective The aim of the study is to examine associations between years firefighting service and eight chronological age-adjusted measures blood leukocyte epigenetic age acceleration: Horvath, Hannum, SkinBloodClock, Intrinsic, Extrinsic, PhenoAge, GrimAge, DNAm telomere length. Methods used a repeated analysis data from 379 incumbent firefighters career departments 100 recruit two departments, across United States. Results Incumbent had on average greater acceleration compared with...
Climate exerts complex influences on leptospirosis transmission, affecting human behavior, zoonotic host population dynamics, and survival of the pathogen in environment. Here, we describe spatiotemporal distribution incidence reported to China's National Infectious Disease Surveillance System from 2004–2014 an endemic region western China, employ distributed lag models at annual sub-annual scales analyze its association with hydroclimatic risk factors explore evidence for potential role a...
Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood. We investigate the accuracy determinants acceleration (GAA), a biomarker biological ageing. hypothesize that prenatal birth characteristics are associated with altered GAA, thereby disrupting foetal examined 372 mother-child pairs from Center for Health Assessment Mothers Children Salinas study primarily Latino...
Abstract Background Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may also have intergenerational effects by which parental ACEs are associated with mental and physical children. Epigenetic programming be one mechanism linking to child health. This study aimed investigate epigenome-wide associations maternal preconception DNA methylation patterns In Center for Health Assessment Mothers Children Salinas study, cord blood...
Healthcare restrictions during the COVID-19 pandemic, particularly in ophthalmology, led to a differential underutilization of care. An analytic approach is needed characterize pandemic health services usage across many conditions.A common analytical framework identified care utilization patterns 261 ophthalmic diagnoses. Using United States eye registry, predictions expected without were established for each diagnosis via models trained on pre-pandemic data. Pandemic effects estimated by...
Background For nearly all human fungal pathogens, the environmental constraints on their distributions remain poorly understood, hindering disease management. Here, we investigated role of zoonotic host presence, soil conditions, and interaction presence Coccidioides immitis, an emerging pathogen causative agent coccidioidomycosis. Methods A long-term experimental study initiated in 2007 Carrizo Plain National Monument, California excluded rodents from certain areas (20 by 20-meter...
The relationship between rainfall, especially extreme and increases in waterborne infectious diseases is widely reported the literature. Most of this research, however, has not formally considered impact exposure measurement error contributed by limited spatiotemporal fidelity precipitation data. Here, we evaluate bias effect estimates associated with misclassification due to data fidelity, using rainfall as an example. We accomplished via a simulation study, followed analysis incident...
Temperature is widely known to influence the spatio-temporal dynamics of vector-borne disease transmission, particularly as temperatures vary across critical thermal thresholds. When temperature conditions exhibit such ‘transcritical variation’, abrupt spatial or temporal discontinuities may result, generating sharp geographical seasonal boundaries in transmission. Here, we develop a machine learning algorithm examine implications transcritical variation for West Nile virus (WNV)...
China contributed 8.9% of all incident cases tuberculosis globally in 2017, and understanding the spatiotemporal distribution pulmonary (PTB) major transmission foci country is critical to ongoing efforts improve population health.We estimated annual PTB notification rates their distributions Sichuan province, a center transmission, from 2005 2017. Time series decomposition was used obtain trend components monthly incidence rate time series. Spatiotemporal cluster analyses were conducted...
Flooding is known to facilitate infectious disease transmission, yet quantitative research on microbiological risks associated with floods has been limited. Pathogen fate and transport models provide a framework examine interactions between landscape characteristics, hydrology, waterborne risks, but have not widely developed for flood conditions. We critically capabilities of current hydrological represent unusual flow paths, nonuniform depths, unsteady velocities that accompany flooding....
Unless a toxicant builds up in deep compartment, intake by the human body must on average balance amount that is lost. We apply this idea to assess arsenic (As) exposure misclassification three previously studied populations rural Bangladesh (n = 11,224), Navajo Nation Southwestern United States 619), and northern Chile 630), under varying assumptions about As sources. Relationships between excretion were simulated taking into account additional sources, as well variability urine dilution...
Introduction Given the rapid geographic spread of dengue and growing frequency intensity heavy rainfall events, it is imperative to understand relationship between these phenomena in order propose effective interventions. However, studies exploring association infection risk have reached conflicting conclusions, potentially due neglect prior water availability mosquito breeding sites as an effect modifier. Methods In this study, we addressed research gap by considering impact for first time....