A5103019230- Sinusitis and nasal conditions
- RNA modifications and cancer
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Vestibular and auditory disorders
- RNA Research and Splicing
- Nasal Surgery and Airway Studies
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Pediatric health and respiratory diseases
- Olfactory and Sensory Function Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Ferroptosis and cancer prognosis
- Retinal and Optic Conditions
- Magnetic confinement fusion research
- Leprosy Research and Treatment
- Cancer Mechanisms and Therapy
- Obstructive Sleep Apnea Research
- Airway Management and Intubation Techniques
- Traditional Chinese Medicine Analysis
- Advanced Glycation End Products research
- Liver Diseases and Immunity
- NF-κB Signaling Pathways
Guiyang Medical University
2016-2025
Affiliated Hospital of Guizhou Medical University
2016-2025
Zhejiang University
2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2024
National Clinical Research Center for Digestive Diseases
2024
Affiliated Hospital of Hebei University
2024
Soochow University
2021
Guangzhou University
2020
Background In recent years, tinnitus has attracted increasing research interest. However, bibliometric analysis of global on is rare. The objective this study was to identify and describe the foci developing trends using a approach. Methods Publications related published from 2001 2020 were searched for in Science Citation Index-Expanded (SCI-E) Social Sciences Index (SSCI) databases Web Core Collection Clarivate Analytics. approach used estimate data, VOSviewer CiteSpace software analyze...
Background The field of otolaryngology has achieved remarkable progress over the past decade due to technological advancements and interdisciplinary integration. Understanding research trends hotspots is essential drive further innovation development. Methods A comprehensive search was conducted on Web Science November 22, 2024, identify top 1,000 most-cited publications from 2014 2024. Data were analyzed using GraphPad Prism v8.0.2, CiteSpace (6.2.4R), VOSviewer (1.6.18) visualize networks....
Background: Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor with very high mortality rate, large number of studies have confirmed the correlation between inflammation tumors involvement inflammation-related regulators in progression HNSCC. However, prognostic model for HNSCC based on genes involved inflammatory factors has not been established. Methods: First, we downloaded transcriptome data clinical information from patients head TCGA GEO (GSE41613) analysis,...
Background The causative relationship between chronic rhinosinusitis (CRS) and depression remains unclear. Herein we employed Mendelian randomization (MR) coupled with single-cell analysis to investigate the causality CRS depression. Methods Data pertaining were mined from genome-wide association study database, a dataset was sourced literature. To explore causality, conducted bidirectional MR using MR-Egger, weighted median, inverse variance (IVW), simple mode, IVW representing most...
Background Research on the treatment of chronic rhinosinusitis (CRS) has increased in recent decades. We undertook a bibliometric and visualization analysis studies CRS to track research trends highlight current “hotspots”. Methods Original publications related were obtained from Science Citation Index-Expanded (SCI-E) Social Sciences Index (SSCI) databases Web Core Collection (WoSCC) Clarivate Analytics between 2001 2020. The country/region, institution, author, journal, references,...
Olfactory dysfunction (OD) accompanied by depression or anxiety is a very common clinical problem, and there has been growing number of studies on OD with in recent decades. This study performed bibliometric visual analyses the literature to derive research trends identify emerging foci. Relevant publications were obtained from Science Citation Index-Expanded Social Sciences Index Web Core Collection databases (2002-2021). CiteSpace VOSviewer applied evaluate foci this domain. The found that...
Background Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral vestibular vertigo. Although BPPV benign, its underlying mechanisms are complicated, and patients diagnosed with significantly affected by it in their daily lives. Hence, this study's purpose was to investigate global trends frontiers field BPPV. Methods We searched research literature published from 2002 2021 on using two databases Web Science Core Collection, we conducted a bibliometric...
As a natural compound isolated from Paeoniae radix, Paeoniflorin (PF) has been shown the antitumor effects in various types of human cancers including glioma, which is one serious tumors central nervous system. Translocator protein 18 KDa (TSPO) to be relevant glioma aetiology. However, regulation PF TSPO and neurosteriods biosynthesis on still unclear. In present study, cell (U87 U251) were cultured used quantify bindings TSPO. Results indicated that there was not significant different...
Abstract Purpose The evidence of apatinib plus immune checkpoint inhibitors (ICIs) and transarterial chemoembolization (TACE) for treating advanced hepatocellular carcinoma (HCC) is limited. This study aimed to compare the treatment efficacy safety ICIs TACE with in these patients. Methods retrospectively enrolled 90 patients HCC treated (A-TACE group, n = 52) or (IA-TACE 38). Results objective response rate was numerically higher IA-TACE group compared A-TACE without statistical...
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by multilineage immune dysregulation, which subsequently causes inflammation, fibrosis, and even cirrhosis of liver. Due to the limitation traditional assays, local hepatic immunopathogenesis PBC has not been fully characterized. Here, we utilize single-cell RNA sequencing technology depict cell landscape decipher molecular mechanisms patients. We reveal that cholangiocytes stellate cells are involved in...
Laryngeal cancer (LCA) is a common head and neck cancer. Lysine demethylase 5B (KDM5B) knockdown expected as new target for prevention. We investigated the molecular mechanism of KDM5B in LCA.The levels KDM5B, microRNA (miR)-139-3p high-mobility-group box 2 (SOX2) LCA tissues cells, normal cells were detected. The effect on was evaluated. upstream miR downstream gene pathway predicted their effects analyzed. Wnt/β-catenin pathway-specific activator agonist delivered into expressing...
URG4, a novel oncogene, is involved in the development and progression of various tumors. This study investigated clinicopathological significance URG4 nasopharyngeal carcinoma (NPC). We used five NPC tissues adjacent normal to determine expression found that was upregulated tissues. Immunohistochemistry analysis expressed positively 97.1% (99/102) samples highly 41.2% (42/102) samples. Its level correlated with advancing clinical stage. Kaplan-Meier log-rank test patients high had poor...
Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), to evaluate therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD. Methods: An AR mouse model was established with ovalbumin, function mice detected by buried food pellet test. Mice OD were intraperitoneally injected CY-09 or saline. The activation microglia astrocytes bulb immunohistochemistry. expression level associated protein Western blot....
Background. SHC SH2 domain-binding protein 1 (SHCBP1), one of the members Src homolog and collagen (Shc) family, has been reported to be overexpressed in several malignant cancers involved tumor progression. However, expression SHCBP1 nasopharyngeal carcinoma (NPC) remains unclear, its clinical significance further elucidated. Methods. The mRNA 35 pair samples NPC adjacent normal tissues was detected by RT-qPCR. level selected cells western blot RT-qPCR, respectively. effects on vitro were...
The RFP is a toroidal magnetic configuration in which plasmas can spontaneously transform into different self-organized states. Among various states, the QSH state has dominant component for field and significantly improves confinement. Many theoretical experimental efforts have investigated transitions among This paper employs MRxMHD model to study properties of other SPEC used compute MHD equilibria KTX. volume KTX partitioned two subvolumes by an internal transport barrier. geometry this...
Objective: To study the survival rate of patients with primary hepatocellular carcinoma (HCC) undergoing clinical surgical treatment and various influencing factors, aim further improving HCC patients. Methods: Sixty who underwent liver cancer resection surgery between January 2020 December 2022 in our hospital were selected. A retrospective analysis was conducted on patients' characteristics (family medical history, alpha-fetoprotein levels, degree cirrhosis, vascular invasion), methods...
Background: Allergic rhinitis (AR) is a common hyperreactive nasal disease in otolaryngology, mainly manifested as rhinorrhea, obstruction, itching, and sneezing. Despite medication immunotherapy, large proportion of patients do not completely eliminate rhinorrhea. In recent years, the use anticholinergics treatment AR has gained attention. However, there currently no consensus on timing selection for treatment. Summary: We reviewed previous studies anticholinergic drugs summarized...