A5034071001- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Neurological Complications and Syndromes
- Vascular Malformations and Hemangiomas
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurogenesis and neuroplasticity mechanisms
- Connective tissue disorders research
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- Neurosurgical Procedures and Complications
- Pluripotent Stem Cells Research
- Cerebrovascular and Carotid Artery Diseases
- Spine and Intervertebral Disc Pathology
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Issues in Pregnancy
- Hemoglobinopathies and Related Disorders
- Ocular Oncology and Treatments
- Child Abuse and Related Trauma
- Optical Imaging and Spectroscopy Techniques
- Aortic Disease and Treatment Approaches
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati
2016-2025
University of Cincinnati Medical Center
2014-2024
University of California, Irvine
2020
Children's Hospital of Orange County
2020
Medical University of South Carolina
2020
Boston Children's Hospital
2020
Harvard University
2020
Cincinnati Sportsmedicine and Orthopaedic Center
2019
University of Utah
2018
The authors present the case of a patient that demonstrates long-standing use megestrol acetate, progesterone agonist, and its association with multiple intracranial meningioma presentation. Discontinuation acetate led to shrinkage tumors complete resolution one tumor. Histological examination demonstrated largest tumor had high (by > 25% cell nuclei) progesterone-positive expression, including receptor (PR) isoform B, compared low expression PR A; there was no evidence estrogen only...
Background Familial cerebral cavernous alformation (CCM) is an autosomal dominant disease caused by mutations in KRIT1, CCM2, or PDCD10. Cases typically present with multiple lesions, strong family history, and neurological symptoms, including seizures, headaches, other deficits. Intracranial hemorrhage (ICH) a severe manifestation of CCM, which can lead to death long-term Few studies have reported ICH rates risk factors familial CCM. We report assess whether CCM lesion burden, severity...
Abstract The glial scar resulting from spinal cord injury is rich in chondroitin sulfate proteoglycan (CSPG), a formidable barrier to axonal regeneration. We explored the possibility of breaching that by first examining functional vitro model. found embryonic stem cell-derived neural lineage cells (ESNLCs) with prominent expression nerve antigen 2 (NG2) survived, passed through an increasingly inhibitory gradient CSPG, and expressed matrix metalloproteinase 9 (MMP-9) at appropriate stage...
Background: Data from the early pandemic revealed that 0.62% of children hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had an arterial ischemic stroke (AIS). In a larger cohort June 2020 to December 2020, we sought determine whether our initial point estimate was stable as continued and understand radiographic laboratory data may clarify mechanisms pediatric AIS in setting SARS-CoV-2. Methods: We surveyed international sites expertise numbers SARS-CoV-2...
We report two unusual cases of a 17-month-old boy with previously undiagnosed lumbar dermal sinus tract terminating in an intradural dermoid cyst and holocord edema or syrinx, presenting paraparesis sphincter dysfunction secondary to intramedullary abscess 26-month-old infected abscess, recurrent episodes meningitis hydrocephalus. Pre-operative magnetic resonance imaging (MRI) studies these patients were initially confused for spinal cord tumor; however, the presence associated made this...
Recent studies suggest that cerebral revascularization surgery may be a safe and effective therapy to reduce stroke risk in patients with sickle cell disease moyamoya syndrome (SCD-MMS).We performed multicenter, retrospective study of children SCD-MMS treated conservative management alone (conservative group)-chronic blood transfusion and/or hydroxyurea-versus plus surgical (surgery group). We monitored cerebrovascular event (CVE) rates-a composite strokes transient ischemic attacks....
To restore proper function to a damaged central nervous system (CNS) through transplantation, it is necessary replace both neural and nonneural elements that arise from different germ layers in the embryo. Mounting evidence indicates importance of signals related vasculogenesis governing proliferation differentiation early CNS development. Here, authors examined whether embryonic stem cell (ESC)-derived progenitors can selectively generate endothelial cells after transplantation...
<h3>BACKGROUND AND PURPOSE:</h3> Widening of the occipital condyle-C1 interval is most specific and sensitive means detecting atlanto-occipital dislocation. Recent studies attempting to define normal measurements in children have varied substantially. This study was performed test null hypothesis that morphology joint do not change as a function age. <h3>MATERIALS METHODS:</h3> Imaging review subjects undergoing CT upper cervical spine for reasons unrelated trauma or developmental...
Chronic occipital and suboccipital headache is a common symptom in patients with Chiari I malformation. These headaches may persist despite appropriate surgical treatment of the underlying pathology via decompression, duraplasty, cerebrospinal fluid diversion. Occipital nerve stimulation has been shown to be effective variety headache/pain syndromes.To review retrospectively our experience primary diagnosis malformation history chronic pain intractable medical therapies.We present...
The authors present the case of a patient who presented acutely with aneurysmal subarachnoid hemorrhage (SAH) and contralateral iatrogenic dural arteriovenous fistula (DAVF). Diagnostic angiography was performed, revealing right-sided middle cerebral artery (MCA) aneurysm left-sided DAVF immediately adjacent to entry ventriculostomy bur hole site. A craniotomy performed for clipping ruptured MCA aneurysm, subsequently underwent endovascular obliteration 3 days later. their treatment an in...
This study was intended to describe and correlate the neuroimaging findings in pediatric patients after sepsis.Retrospective chart review.Single tertiary care PICU.Patients admitted Cincinnati Children's Hospital Medical Center with a discharge diagnosis of sepsis or septic shock between 2004 2013 were crossmatched who underwent during same time period.All studies that occurred subsequent event reviewed, all new imaging recorded classified. As many experienced multiple events and/or had...