A5033816658- interferon and immune responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Occupational and environmental lung diseases
- Biomarkers in Disease Mechanisms
- Inflammation biomarkers and pathways
- Immune Response and Inflammation
- Viral Infections and Outbreaks Research
- RNA modifications and cancer
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Pediatric health and respiratory diseases
- Bone and Dental Protein Studies
- Viral Infections and Vectors
- Viral Infections and Immunology Research
China-Japan Friendship Hospital
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
National Clinical Research
2023
China National Pharmaceutical Group Corporation (China)
2021-2022
Beijing Ditan Hospital
2017-2019
Capital Medical University
2017-2019
ABSTRACT Interferon-induced transmembrane proteins (IFITMs) are restriction factors that inhibit the infectious entry of many enveloped RNA viruses. However, we demonstrated previously human IFITM2 and IFITM3 essential host facilitating coronavirus (HCoV) OC43. In a continuing effort to decipher molecular mechanism underlying IFITM differential modulation HCoV entry, investigated roles structural motifs important for protein posttranslational modifications, intracellular trafficking,...
Interferons (IFNs) control viral infections by inducing expression of IFN-stimulated genes (ISGs) that restrict distinct steps replication. We report herein gamma-interferon-inducible lysosomal thiol reductase (GILT), a lysosome-associated ISG, restricts the infectious entry selected enveloped RNA viruses. Specifically, we demonstrated GILT was constitutively expressed in lung epithelial cells and fibroblasts its could be further induced type II interferon. While overexpression inhibited...
Background: Coal worker's pneumoconiosis (CWP) is a chronic occupational disease mainly caused by coal dust inhalation in miners. This study aimed to investigate the clinical value of Osteopontin (OPN), KL-6, Syndecan-4 and Gremlin-1 as serum biomarkers CWP. Patients Methods: We integrated reported lung tissues transcriptome data patients with silica-exposed alveolar macrophage microarray identify four CWP-associated biomarkers. The concentrations Osteopontin, Krebs von den Lungen-6 (KL-6),...
Purpose: CWP is an untreatable but preventable fibrotic lung disease caused by the chronic inhalation of coal dust. Genetic factors such as polymorphisms play important role in development CWP. The present study investigated association between SMAD4 and NLRP3 risk a Chinese Han population. Patients Methods: rs10502913 NLRP3rs1539019 were examined 292 subjects 315 dust-exposed controls. genotypes analyzed using direct sequencing. allele genotype proportion cases controls compared chi-square...
COPD is a complex respiratory disease characterized by chronic airway inflammation and the airflow limitations are not fully reversible due to combination of genetic environmental factors. Genetic factors such as polymorphisms, may affect susceptibility COPD. In present study, we examined association between polymorphisms three genes risk in Chinese Han population.A total 375 patients 284 control subjects were recruited from November 2018 June 2021. Data on demographic basic information,...
Coal workers' pneumoconiosis (CWP) is a chronic inflammatory and fibrotic pulmonary disease that involves complex interaction of multiple environmental genetic factors. Polymorphism, as factor, may affect the onset in susceptible populations. The present study investigated association between polymorphisms six genes CWP risk Chinese Han population.Six (CASP8 rs3834129, IL1A rs1800587, IL6 rs1800796, IL4 rs2070874, TNFA rs361525, NLRP3 rs1539019) were examined 222 subjects 247 dust-exposed...
Interferon-induced transmembrane proteins (IFITMs), a class of novel discovered viral restriction factors, are widely expressed in human tissue cells, mainly located plasma membrane and endolysosomal comparments, which the main targets virus entry. By inhibiting fusion between cell membrane, IFITMs restrict entry broad spectrum viruses, including Ebola virus, influenza A severe acute respiratory syndromes (SARS) coronavirus, dengue West Nile Zika virus. Although IFITM has been shown to be...
Objective To establish FLP-IN T Rex 293 cell line inducibly expressing human interferon-inducible transmembrane protein 3 (IFITM3) and provide a model to explore the mechanism of IFITM3 inhibiting vial entry influenza virus. Methods Full-length cDNA was cloned into pcDNA5/FRT/TO expression vector. Then established by co-transfection IFITM3/pcDNA5/FRT/TO vector pOG44 plasmid following antibiotic screening. The inducible in cells tested Western blot immunofluorescence. inhibitory effect...
COPD is a respiratory disease caused by combination of genetic and environmental factors. Polymorphism, as factor, can affect the susceptibility COPD. In this study, we assessed relationship between polymorphisms three genes risk in Chinese Han population.A total 376 patients diagnosed with 284 control subjects were enrolled study. Multivariate logistic regression analysis was used to analyze association (SMAD4 rs10502913, IL-4 rs2070874, HSPA1L rs2227956) susceptibility.The SMAD4 rs10502913...