A5066105534- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Immune responses and vaccinations
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Microbial infections and disease research
- Bacterial Identification and Susceptibility Testing
- Immunodeficiency and Autoimmune Disorders
- Virology and Viral Diseases
- Infectious Diseases and Tuberculosis
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Immune cells in cancer
- Animal Behavior and Welfare Studies
- Viral gastroenteritis research and epidemiology
Animal and Plant Health Agency
2011-2025
Veterinary Medicines Directorate
2006-2011
Control of bovine tuberculosis (TB) in cattle has proven particularly challenging where reservoirs infection exist wildlife populations. In Britain and Ireland, control is hampered by a reservoir Eurasian badgers ( Meles meles ). Badger culling positive negative effects on TB difficult, costly controversial. Here we show that Bacillus Calmette-Guérin (BCG) vaccination captive reduced the progression, severity excretion Mycobacterium bovis after experimental challenge. clinical field study,...
Controlling bovine tuberculosis (bTB) in livestock is often hindered by the presence of a wildlife reservoir, such as Eurasian badger UK and Ireland. Vaccinating badgers against bTB can reduce severity Mycobacterium bovis infection potential onwards transmission to cattle, other species, thus combined with population control might provide additional benefits (and reference models). To evaluate effects co-administration vaccine (BCG) contraceptive (GonaCon), captive were injected...
In the UK and Ireland, European badger is main wildlife reservoir for Mycobacterium bovis (M. bovis), causal agent of bovine tuberculosis (bTB). The ability to diagnose M. infection in badgers critical understanding epidemiology this species informing control strategies. study we determined sensitivity specificity a lateral flow assay (Dual Path Platform (DPP) VetTB assay) identify infected live using two blood sample types: fresh whole (suitable immediate testing field without further...
The European badger (Meles meles) is a reservoir host of Mycobacterium bovis and responsible for proportion the tuberculosis (TB) cases seen in cattle United Kingdom Republic Ireland. An injectable preparation bacillus Calmette-Guérin (BCG) vaccine licensed use badgers UK its forms part bovine TB eradication plans England Wales. However, there are practical limitations to widespread application an research priority development oral deliverable bait. Previous studies reported successful...
In Europe, badgers (Meles meles) are recognized as major tuberculosis (TB) reservoir hosts with the potential to transmit infection associated cattle herds. Recent studies in Spain have demonstrated that vaccination a heat-inactivated Mycobacterium bovis vaccine (HIMB) successfully protects captive wild boar and red deer against progressive disease. The aim of this study was evaluate efficacy two oral vaccines TB badger model: live-attenuated M. bacillus Calmette-Guérin BCG (Danish strain)...
Bovine tuberculosis (bTB), caused by Mycobacterium bovis, represents a major animal health issue. In the United Kingdom and Republic of Ireland, European badgers (Meles meles) have been shown to act as reservoir M. bovis infection, hindering eradication bTB in livestock. The availability suitable diagnostic assays, particularly those that may be applied "trap-side" setting, would facilitate implementation wider range disease control strategies. Here we evaluate Dual Path Platform (DPP) VetTB...
Abstract European badgers ( Meles meles ) have been identified as wildlife reservoirs for Mycobacterium bovis in the UK and Ireland, may also a role epidemiology of animal tuberculosis other regions. Thus, detection M. ‐infected be required purposes surveillance monitoring disease levels infected populations. Current serological assays to detect infection live badgers, while rapid inexpensive, show limited diagnostic sensitivity. Here we describe evaluate new ELISA platforms recognition P22...
Oral vaccination with Mycobacterium bovis Bacille of Calmette and Guerin (BCG) has provided protection against M. to badgers both experimentally in the field. There is also evidence suggesting that persistence live BCG within host important for maintaining TB. Here we investigated capacity badger inductive mucosal sites absorb maintain BCG. The targeted mucosae were oropharyngeal cavity (tonsils sublingual area) small intestine (ileum). We showed significant quantities persisted tissues...
Badgers (Meles meles) are a major tuberculosis (TB) reservoir in Europe, with the potential to transmit infection cattle. Here we assessed whether recently described oral vaccine based on heat-inactivated Mycobacterium bovis (HIMB), delivered as edible baits, can protect badgers from infection. Eight were given individually five each one consisting of ball peanut butter, natural and oat flakes including dose containing 5 × 107 colony-forming units. In parallel, control group seven did not...
A real-time PCR assay for the measurement of gamma interferon (IFN-gamma) mRNA in European badger (Meles meles) blood cultures was developed. The levels IFN-gamma stimulated with either bovine or avian tuberculin specific mycobacterial antigens were compared those a nonstimulated control culture as basis determining tuberculosis (TB) status live badgers. validated by testing 247 animals which there matching data from postmortem examination and tissues. Relative changes response to found be...
Bovine tuberculosis (TB) in Great Britain adversely affects animal health and welfare is a cause of considerable economic loss. The situation exacerbated by European badgers (Meles meles) acting as wildlife source recurrent Mycobacterium bovis infection to cattle. Vaccination against TB possible means reduce control bovine TB. delivery vaccine oral bait holds the best prospect for vaccinating over wide geographical area. There are practical limitations volume concentration Bacillus Calmette...
Tuberculosis (TB) vaccination could be used as a key part of integrated strategies for the disease’s control if an effective and safe vaccine under field conditions is obtained. Recent studies in Spain have evaluated protective efficacy two oral vaccines against experimental challenge with live intra-bronchial Mycobacterium bovis captive badgers: live-attenuated M. BCG (Danish strain) heat-inactivated (HIMB) vaccine. With objective increasing knowledge cellular development progress infection...
In wildlife disease management there are few diseases for which vaccination is a viable option. The human vaccine BCG has been used the control of bovine tuberculosis in badgers since 2010 and expected to increase. Understanding long-term effects repeated campaigns on prevalence vital, but modelling thus far generally assumed that provides perfect protection proportion population, animals exposed have second independent chance becoming protected. We held workshop with experts field obtain...