A5101405556- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Air Quality Monitoring and Forecasting
- Immune cells in cancer
- Wheat and Barley Genetics and Pathology
- Carcinogens and Genotoxicity Assessment
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Oral microbiology and periodontitis research
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Circular RNAs in diseases
- Energy and Environment Impacts
- Wind and Air Flow Studies
- Pancreatic function and diabetes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Oral Health Pathology and Treatment
- Biomarkers in Disease Mechanisms
- Urban Heat Island Mitigation
- Folate and B Vitamins Research
- DNA Repair Mechanisms
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Infrared Target Detection Methodologies
Tianjin University of Traditional Chinese Medicine
2025
Shanghai Institute of Technical Physics
2024
Chinese Academy of Sciences
2024
National Institute for Occupational Health and Poison Control
2005-2023
Capital Medical University
2021-2022
Capital University
2022
Hebei Agricultural University
2020-2021
Integrated Chinese Medicine (China)
2017-2018
Beijing Center for Disease Prevention and Control
2017
The 309th Hospital of Chinese People's Liberation Army
2016
Abstract The role of LOXL2 in cancer has been widely demonstrated, but current therapies targeting are not yet fully developed. We believe that selective nature-derived inhibition may provide a better therapeutic approach for the treatment cancer. Therefore, we adopted comprehensive combining deep learning and traditional computer-aided drug design methods to screen inhibitors. Bioactivity affinity potential inhibitors were determined by molecular docking virtual screening. At same time,...
The relationship between diesel engine exhaust (DEE), a known lung carcinogen, and immune/inflammatory markers that have been prospectively associated with cancer risk is not well understood. To provide insight into these associations, we conducted cross-sectional molecular epidemiology study of 54 males highly occupationally exposed to DEE 55 unexposed male controls from representative workplaces in China. We measured plasma levels 64 all subjects using Luminex bead-based assays, compared...
The International Agency for Research on Cancer recently classified diesel engine exhaust (DEE) as a Group I carcinogen based largely its association with lung cancer. However, the exposure-response relationship is still subject of debate and underlying mechanism by which DEE causes cancer in humans not well understood.We conducted cross-sectional molecular epidemiology study truck testing facility 54 workers exposed to wide range (ie, elemental carbon air levels, median range: 49.7,...
Urinary mutagenicity reflects systemic exposure to complex mixtures of genotoxic/carcinogenic agents and is linked tumor development. Coal combustion emissions (CCE) diesel engine exhaust (DEE) are associated with cancers the lung other sites, but their influence on urinary unclear. We investigated associations between CCE or DEE mutagenicity. In two separate cross-sectional studies nonsmokers, organic extracts urine were evaluated for levels using strain YG1041 in Salmonella (Ames) assay....
Type 1 diabetes (T1D), an autoimmune disease, occurs most commonly in children. Identifying altered gene expression peripheral blood mononuclear cells (PBMCs) of T1D may lead to new strategies for preserving or improving β-ell function patients with T1D.The Gene Expression Omnibus database was searched microarray studies PBMCs T1D. Subsequently, datasets from multiple were integrated obtain differentially expressed genes (DEGs) between and normal controls (NC). analysis performed determine...
Objectives: TP53 is an important tumor suppressor gene to maintain genomic integrity, and its mutations increase the susceptibility oral carcinoma. Previous published studies have reported association of codon 72 polymorphism with carcinoma, but results remain controversial inconclusive. Methods: We therefore performed meta-analysis based on a comprehensive search in PubMed, EMBASE, Google Scholar databases up August 19, 2017. Results: Total 3,525 cases 3,712 controls from 21 case-control...
Our study aims to detect the underlying mechanism of suppressive effect Follistatin-like 1 (FSTL1) on lung metastasis triple negative breast cancer (TNBC). We found that FSTL1 had no proliferation and 4T1 cells in vitro, while tumor-bearing Fstl1 heterozygous (Fstl1+/-) mice, number anti-tumor T lymphocytes was significantly reduced with increase metastasis. Impaired development can cause dysfunction adaptive immune system, which promotes Therefore cell further investigated. Lower population...
Background Millions of workers worldwide are exposed to diesel engine exhaust (DEE), a known genotoxic carcinogen. Alu retroelements repetitive DNA sequences that can multiply and compromise genomic stability. There is some evidence linking altered repeats cancer elevated mortality risks. However, whether influenced by environmental pollutants unexplored. In an occupational setting with high DEE exposure levels, we investigated associations repeat copy number. Methods A cross-sectional study...
Diesel engine exhaust (DEE) is classified as a Group 1 human carcinogen. Using targeted proteomics approach, we aimed to identify proteins associated with DEE and characterize these markers understand the mechanisms of DEE-induced carcinogenicity. In this cross-sectional molecular epidemiology study, measured elemental carbon (EC) using personal air monitor quantified 1317 in serum SOMAScan assay (SOMALogic) among 19 diesel exposed factory workers unexposed controls. We used linear...
Infrared imaging systems play an important role in many fields. With the increasing demand for system miniaturization, infrared computational technology achieves aberration correction through image restoration algorithms, becoming effective way to simplify configuration. The accurate modeling of detector noise is a critical step technology, and its precision directly impacts efficacy restoration. This article elucidates random model pyroelectric detectors experimental research proposes...
Diesel engine exhaust (DEE) is an established lung carcinogen, but the biological mechanisms of diesel-induced carcinogenesis are not well understood. MicroRNAs (miRNAs) small noncoding RNAs that play a potentially important role in regulating gene expression related to cancer. We conducted cross-sectional molecular epidemiology study evaluate whether serum levels miRNAs altered healthy workers occupationally exposed DEE compared unexposed controls. two-stage study, first measuring 405 pilot...
OBJECTIVE To investigate the alteration of activator protein-1 (AP-1) luciferase activity in human embryo lung fibroblasts (HELF) after exposed to silica, and role mitogen activated protein kinase (MAPK)/AP-1 pathway on silica-induced cell cycle changes. METHODS After HELF cells were treated with 200 microg/ml immunofluorescence assays employed detect translocation phosphorylation level extracellular signal-regulated (ERK) c-Jun N-terminal (JNK), flow cytometry was used distributions cycle,...
Abstract Background The inositol phospholipid signaling system, which is based on the metabolism of phosphoinositide (PI), mediates plant growth, development, and responses to adversity. Diacylglycerol kinase (DGK) one key enzymes in PI-cycle, catalyzes phosphorylation diacylglycerol (DAG) form phosphatidic acid (PA). To date, comprehensive genomic functional analyses DGK genes have not been reported wheat. Results In this study, 20 gene family members from heterologous hexaploid wheat...
OBJECTIVE To study the role of Phosphatidylinositol 3 kinase (PI3K) in silica-induced DNA double strand break repair human embryo lung fibroblasts (HELF). METHODS Control HELF cells and DN-Deltap85 (HELF transfected with Dominant negative mutant PI3K) were treated 200 microg/ml silica for different times. The expression levels phosphor-H2AX (H2AX), Ku70, Ku80 DNA-PKcs determined by Western blot. Furthermore, breaks measured neutral comet assay after 0, 12 24 h. RESULTS After treatment times,...
Abstract Rationale: Recent epidemiological studies show that Diesel Engine Exhaust (DEE) exposure is associated with lung cancer, however the mechanism by which this occurs not well understood. The goal of study was to assess transcriptomic alterations in nasal epithelium DEE exposed workers from factories where diesel engines are utilized. Methods: Nasal brushings were obtained 41 subjects who work a factory exposure, and 38 comparable control without any exposure. median Elemental Carbon...
OBJECTIVE To investigate the reverse effect of all-trans retinoic acid (ATRA) on Benzo (a) pyrene (B P)-induced cyclin D1, CDK4, E2F-1 and E2F-4 expression cell cycle progression in human embryo lung fibroblast (HELF). METHODS After HELF cells was treated with ATRA, they were exposed to 2 micromol/L B P. Western blotting employed detect protein level; RNA transfection techniques used ATRA-induced signal pathway; flow cytometry progression. RESULT treatment P for 24 h, D1 both increased...
Abstract Immune cell infiltration in the tumor microenvironment is associated with cancer prognosis. Tumor-associated macrophages (TAMs) play an essential role initiation, progression, and metastasis. Follistatin-like protein 1 (Fstl1), a glycoprotein widely expressed human mouse tissues, suppressor various cancers regulator macrophage polarization. However, how Fstl1 affects crosstalk between breast cells remains unclear. Analyzing public data, we found that expression significantly...
Abstract Immune cell infiltration in the tumor microenvironment is associated with cancer prognosis. Tumor-associated macrophages (TAMs) play an essential role initiation, progression, and metastasis. Follistatin-like protein 1 (Fstl1), a glycoprotein widely expressed human mouse tissues, suppressor various cancers regulator macrophage polarization. However, how Fstl1 affects crosstalk between breast cells remains unclear. Analyzing public data, we found that expression significantly...
Abstract Immune cell infiltration in the tumor microenvironment is associated with cancer prognosis. Tumor-associated macrophages (TAMs) play an essential role initiation, progression, and metastasis. Follistatin-like protein 1 (Fstl1), a glycoprotein widely expressed human mouse tissues, suppressor various cancers regulator macrophage polarization. However, how Fstl1 affects crosstalk between breast cells remains unclear. Analyzing public data, we found that expression significantly...