A5101928943- Liver Disease and Transplantation
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Nutrition, Genetics, and Disease
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Nitric Oxide and Endothelin Effects
- Glutathione Transferases and Polymorphisms
- Urinary Bladder and Prostate Research
- Supercapacitor Materials and Fabrication
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Autophagy in Disease and Therapy
- Computational Drug Discovery Methods
- Advanced Proteomics Techniques and Applications
- Cancer-related gene regulation
- Neuroscience and Neuropharmacology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Adipose Tissue and Metabolism
- Advanced Thermodynamic Systems and Engines
Hunan Normal University
2019-2023
Hunan Provincial People's Hospital
2012-2023
Analysis Group (United States)
2023
Boston University
2023
University of Shanghai for Science and Technology
2019-2022
Soochow University
2020
Harbin Medical University
2020
Capital Medical University
2011
Methamphetamine (MA) abuse results in neurotoxic outcomes, including increased anxiety and depression. Studies have reported an association between MA exposure anxiety, nonetheless, the underlying mechanism remains elusive. In present study, we developed a mouse model of anxiety-like behavior induced by administration. RNA-seq was then performed to profile gene expression patterns hippocampus (HIPP), differentially expressed genes (DEGs) were significantly enriched signaling pathways related...
Background: Gallbladder cancer (GBC) is often diagnosed at an advanced stage with limited therapeutic options and poor prognosis. The five-year survival rate of this when below 5%, the median time less than a year standard gemcitabine-based chemotherapy. Survival benefit second-line treatment unknown. Thus, there urgent need for novel strategies targeted therapy based on next generation sequencing (NGS) may be value. Methods: Comprehensive genomic profiling (CGP) was performed NGS panel...
690 Background: NALIRIFOX (liposomal irinotecan + 5-fluorouracil/leucovorin oxaliplatin) demonstrated significantly improved OS compared to 1L gemcitabine nab-paclitaxel in the phase 3 NAPOLI trial (NCT04083235). The median (95% CI) intention-to-treat population (N= 383) was 11.1 (10.0, 12.1) months. However, relative efficacy of versus FFX (irinotecan oxaliplatin), another standard care for treatment mPDAC, has not been studied. To further contextualize findings from trial, current study...
In recent years, ER+ and HER2- breast cancer of adjuvant therapy has made great progress, including chemotherapy endocrine therapy. We found that the responsiveness treatment was related to prognosis patients. However, reliable prognostic signatures based on drug resistance-related markers have not been well confirmed, This study in amied establish a gene signature for risk stratification cancer.We used data from The Cancer Genoma Atlas (TCGA) dataset expression database (Gene Expression...
Abstract Sarcopenia is a complex polygenic disease, and its molecular mechanism still unclear. Whole lean body mass (WLBM) heritable trait predicting sarcopenia. To identify genomic loci underlying, we performed whole‐exome sequencing (WES) of WLBM variation with high depth (more than 40*) in 101 Chinese subjects. We then replicated the major findings large‐scale UK Biobank (UKB) cohort ( N = 217,822) for WLBM. The results four single‐nucleotide polymorphisms (SNPs) were significant both...
Abstract Background Liposarcoma is a malignant mesenchymal tumor that most commonly involves the retroperitoneum and lower extremities. However, liposarcoma of esophagus has been rarely reported in literature. Case presentation We report case 46-year-old man with complaint intermittent dysphagia for 6 years, accompanied paroxysmal vomiting pedicled to mouth. Imaging studies showed huge mixed density lesion middle esophageal lumen. Surgical resection was performed through an external cervical...
Nickel based materials have been extensively reported to be highly effective for the electrochemical oxidation of urea in wastewater, which are critical energy utilization as well contamination elimination. In this study, two Ni containing nickel-aluminum layered double hydroxides (NiAl-LDH) and metal organic framework (Ni-MOF) were synthesized compared with disk towards reaction (UOR). Physical characterization proved existence same valence +2 as-prepared catalysts. Moreover, analysis...
Whole body lean mass (WBLM) is a heritable trait predicting sarcopenia. To identify genomic locus underlying WBLM, we performed genome-wide association study of fat-adjusted WBLM in the Framingham Heart Study (FHS, N = 6,004), and replicated Kansas City Osteoporosis (KCOS, 2,207). We identified novel 3p27.1 that was associated with (lead SNP rs3732593 P 7.19 × 10-8) discovery FHS sample, lead successfully KCOS sample (one-sided 0.04). Bioinformatics analysis found this its adjacent SNPs had...
Abstract Background: Ovarian cancer ascites are a clinical conundrum in the process of diagnosis and treatment, chemotherapy is main treatment. The efficacy prognostic assessment has been subject continuous exploration. Methods: Affymetrix HTA2.0 microarray analysis ovarian without with chemotherapy, as well metabolomics techniques, showed that AMY1A gene expression was significantly higher than chemotherapy. Results: tissues, ascitic precipitated cells supernatants, high sAMY-1α negatively...
Objective To investigate the impact of splenectomy with periesophagogastric devascularization on liver function patients cirrhosis and hypersplenism. Methods Clinical data 177 hypersplenism who underwent in Third Affiliated Hospital Sun Yat-sen University from January 2010 to December 2012 were retrospectively analyzed. There 120 males 57 females mean age (54±13) years old. The informed consents all obtained ethical committee approval was received. Firstly performed during operation,...
Objective To investigate the opportunity and skill of surgery for pancreatic sinistral portal hypertension. Methods Clinical data were retrospectively analyzed on 15 cases hypertension admitted from Dec 2015 to 2017. Results All fiften underwent surgical treatment, among them three initially treated conservatively in early stage surgically gastrointestinal bleeding, 12 with definite disease first stage. Three patients second recurrent bleeding. The followed up 6 18 months...