A5073102590- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Helicobacter pylori-related gastroenterology studies
- Biochemical and Molecular Research
- Bacteriophages and microbial interactions
- Immunodeficiency and Autoimmune Disorders
- Antibiotic Use and Resistance
- Plant Virus Research Studies
- Diphtheria, Corynebacterium, and Tetanus
- Pharmaceutical and Antibiotic Environmental Impacts
- Malaria Research and Control
- Evolution and Genetic Dynamics
- Veterinary medicine and infectious diseases
- Infectious Diseases and Mycology
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Plant-based Medicinal Research
- Microbial Natural Products and Biosynthesis
- Medical Research and Treatments
- Parasites and Host Interactions
- Escherichia coli research studies
- Bacterial Identification and Susceptibility Testing
Albert Einstein College of Medicine
2019-2024
Jacobs (United States)
2021
Pondicherry University
2011-2019
Montefiore Medical Center
2019
National Institute of Research in Tuberculosis
2019
Although not previously known to cause human infections, Kocuria species have now emerged as pathogens, mostly in compromised hosts with severe underlying disease. Recently, there has been an increasing incidence of different types infections reported, most likely due the adoption better identification methods. Here, we report a case peritonitis caused by rosea diabetic nephropathy patient who was on continuous ambulatory peritoneal dialysis. Sepsis and K. our yielded two identical isolates...
The emergence of drug resistance in Helicobacter pylori has resulted a greater need for susceptibility-guided treatment. While the alleles associated with to clarithromycin and levofloxacin have been defined, there are limited data regarding molecular mechanisms underlying other antimicrobials. Using H. isolates from 42 clinical specimens, we compared phenotypic whole-genome sequencing (WGS)-based detection resistance. Phenotypic correlated presence 23S rRNA (A2142G/A2143G) (kappa...
Mycobacterium tuberculosis (Mtb) possesses five type VII secretion systems (T7SS), virulence determinants that include the apparatus and associated substrates. Mtb strains deleted for genes encoding substrates of ESX-3 T7SS, esxG or esxH, require iron supplementation in vitro growth are highly attenuated vivo. In a subset infected mice, suppressor mutants esxH deletions were isolated, which enabled to high titers restored virulence. Suppression was conferred by mechanisms cause...
ABSTRACT The molecular epidemiology and carbapenem resistance mechanisms of clinical isolates Acinetobacter baumannii obtained from a south Indian tertiary care hospital were investigated by repetitive extragenic palindromic sequence PCR (REP‐PCR) multi‐locus typing (MLST). Analysis resistant determinants was achieved screening for the presence genes encoding OXA‐carbapenemases, metallo‐β‐lactamases (MBLs) efflux pumps. REP‐PCR generated around eight clusters high heterogeneity; these, two...
Inhibition of MurA in open conformation by orientin and closed quercetin-3-<italic>O</italic>-<sc>d</sc>-glucuronide with efficient inhibitory constant values.
Acinetobacter baumannii is an important human pathogen and considered as a major threat due to its extreme drug resistance. In this study, the genome of hyper-virulent MDR strain PKAB07 A. isolated from Indian patient was sequenced analyzed understand mechanisms virulence, resistance evolution. Comparative analysis revealed virulence related genes scattered throughout genome, instead being organized island, indicating highly mosaic nature genome. Many intermittent horizontal gene transfer...
ABSTRACT Mycobacterium tuberculosis ( Mtb ) is an intracellular pathogen that survives and grows in macrophages. A mechanism used by to achieve survival secrete effector molecules arrest the normal process of phagosome maturation. Through maturation (PMA), remains early avoids delivery degradative phagolysosomes. One PMA secreted SapM phosphatase. Because host target SapM, phosphatidylinositol-3-phosphate (PI 3 P), located on cytosolic face phagosome, needs not only be released mycobacteria...
Secretory N-acyl homoserine lactones (AHLs) mediate quorum sensing (QS) in bacteria. AHLs are shown to be inhibitory for an unrelated group of bacteria and might mimic host signalling elements, thereby subverting the regulatory events cells. This study investigated AHL produced by Acinetobacter baumannii analysed its effect on other bacterial species mammalian Chemically characterized had m/z value 325 with a molecular formula C18H31NO4 showed potential against Staphylococcus aureus....
Staphylococcus aureus is a major human pathogen that also causes important infections in cattle and sheep. The present study aimed to test genetic diversity among strains of S. isolated from (n=34) humans (n=22) by DNA typing.Fluorescent amplified fragment length polymorphism (FAFLP) the genotyping tool used study. presence mecA Panton-Valentine leukocidin (PVL) genes these strain groups was checked.A dendrogram deduced FAFLP showed all clustered into 10 (A-J) with relative divergence less...
<b>Introduction:</b> <i>Pseudomonas aeruginosa</i> is a potent opportunistic nosocomial human pathogen among Gram-negative bacteria causing various life-threatening infections in patients from Intensive Care Units. This bacterium has become resistant to almost all commonly available antibiotics with limited treatment options. Multi drug <i>P. (MDRPA) major cause of concern hospital acquired infections. It uses distinctive mechanisms virtually the such as Metallo β-lactamases (MBL)...
BackgroundExtended spectrum betalactamase (ESBL)-producing organisms are a major cause of hospital-acquired infections.ESBL-producing Escherichia coli (E.coli) have been recovered from the hospital environment.These drugresistant also found to be present in humans as commensals.The investigation intended isolate ESBL-producing E. gut already infected patients; date, only few studies shown evidence microflora source infection. AimsThis study aimed detect presence ESBL genes E.coli that...
Significance Despite decades of research, we lack an effective vaccine against influenza, a deadly virus that costs the United States nearly $90 billion annually. Current strategies do not translate into highly protective immunity circulating and novel influenza strains. Here, demonstrate herpes simplex viral (HSV) vector expressing hemagglutinin can be used to elicit response influenza. The efficacy this is abrogated by preexisting HSV, protects lethal HSV challenge, elicits functional...
Phenotypic testing for drug susceptibility of Mycobacterium tuberculosis is critical to basic research and managing the evolving problem antimicrobial resistance in management, but it remains a specialized technique which access severely limited. Here, we report on development validation an improved phage-mediated detection system M. We incorporated nanoluciferase (Nluc) reporter gene cassette into TM4 mycobacteriophage genome create phage TM4-nluc. assessed performance this context cellular...
The objective of the present study is to investigate diverse resistance determinants, their association with insertion sequence mobile elements and predilection a particular clone for such associations in Acinetobacter baumannii.Fifty-four consecutive isolates collected during 2011-2012 from tertiary care hospital were subjected susceptibility testing followed by PCR screening commonly reported β-lactamases 16S rRNA methyltransferase encoding genes. integrity resistance-nodulation-cell...
Acinetobacter baumannii has emerged as one of the most common nosocomial pathogens and is considered to be a significant threat public health worldwide. Here, we present draft genome sequence multidrug-resistant clinical strain A. PKAB07 isolated from wound infection in India during 2011 2012.
Genome sequencing and assembly of viral genomes within the
Helicobacter pylori is found in the gut lining of more than half world's population, causes gastric ulcers, and contributes to stomach cancers. Menaquinone synthesis H. relies on rare futalosine pathway, where 5′-methylthioadenosine nucleosidase (MTAN) proposed play an essential role. Transition state analogues MTAN, including BuT-DADMe-ImmA (BTDIA) MeT-DADMe-ImmA (MTDIA), exhibit bacteriostatic action against numerous diverse clinical isolates with minimum inhibitory concentrations (MIC's)...
Tuberculosis, caused by