A5041995309- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Vaccine Coverage and Hesitancy
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Vitamin D Research Studies
- Respiratory viral infections research
- Cystic Fibrosis Research Advances
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Kawasaki Disease and Coronary Complications
- HIV/AIDS drug development and treatment
- Digestive system and related health
- Influenza Virus Research Studies
- Fatty Acid Research and Health
- Obstructive Sleep Apnea Research
- Meta-analysis and systematic reviews
- Delphi Technique in Research
- Alcohol Consumption and Health Effects
- Viral Infections and Immunology Research
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
Luigi Sacco Hospital
2020-2025
University of Milan
2015-2025
ASST Fatebenefratelli Sacco
2020-2025
Ospedale dei Bambini Vittore Buzzi
2021
Azienda Ospedaliero Universitaria Maggiore della Carita
2020
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2019-2020
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015
There are growing evidence of clinical manifestations other than acute respiratory syndrome in severe associated with coronavirus 2-infected children. In our multicenter retrospective analysis, we observed among 127 2 positive children that the presence gastrointestinal symptoms was more frequently and critical phenotype (P = 0.029). Moreover, having reported patients who developed cardiac impairment.
To assess whether the use of revised Cochrane risk bias tool for randomized trials (RoB2) in systematic reviews (SRs) adheres to RoB2 guidance.We searched MEDLINE, Embase, Library from 2019 May 2021 identify SRs using RoB2. We analyzed methods and results sections see was assessed at outcome measure level applied primary outcomes SR as per guidance. The relation between characteristics adequacy examined by logistic regression analysis.Two hundred-eight were included. could adherence 137 12...
Abstract Background Newborns under 6 months of age are at high risk hospitalization for acute respiratory failure following SARS‐CoV‐2 infection. Herein, we analyzed neonatal protection against passively acquired after mother vaccination and/or infection (hybrid immunity). Methods We enrolled seventy‐eight newborns immunized mothers before or during pregnancy, through Infants were stratified based on the anamnestic lack (SARS‐CoV‐2 Vaccinated – SV)/presence Infected and SIV) COVID‐19...
Background Data on the efficacy of three SARS-CoV-2 mRNA BNT162b2 vaccine doses and role previous SARS-CoV-2-infection in enhancing immunogenicity HIV-vertically-infected people living with HIV (PLWH) are limited, as is duration vaccine-induced responses. Methods plasma neutralizing activity (NA) against European (B.1), Delta (B.1.617.2) Omicron (B.1.1.529) variants cell-mediated immunity (CMI) were analyzed 29 ART-treated young PLWH (mean age 27.9 years) 30 healthy controls (HC) who...
Vitamin D and omega 3 fatty acid (ω-3) co-supplementation potentially improves type 1 diabetes (T1D) by attenuating autoimmunity counteracting inflammation. This cohort study, preliminary to a randomized control trial (RCT), is aimed at evaluating, in series of T1D children assuming Mediterranean diet an intake cholecalciferol 1000U/day from onset, if ω-3 preserves the residual endogen insulin secretion (REIS). Therefore, 22 “new onsets” 2017 received (eicosapentenoic (EPA) plus...
Severe acute respiratory syndrome coronavirus 2 infection in children mainly shows a milder course. In complicated cases, it is unknown whether inflammation predictive of disease severity, as adults. Moreover, cardiac involvement anecdotally described. We report the case 2-month-old infant with severe presenting fever, tachycardia and elevated interleukin-6, who was diagnosed myocarditis treated immunoglobulins.
While the risk of SARS-CoV-2 infection and/or COVID-19 disease progression in general population has been largely assessed, its impact on HIV-positive individuals remains unclear. We present clinical and immunological data collected a cohort HIV-infected young during first wave pandemic. RNA, virus-specific antibodies, as well expression factors involved anti-viral immune response were analyzed. Moreover, we set up an vitro coinfection assay to study mechanisms correlated process. Our...
Vitamin D plays an immunoregulatory activity. The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 Treg circulating subsets, mainly Treg/inducible costimulatory-positive (ICOS+), which seems have a protective role in autoimmunity, children with type 1 diabetes mellitus (T1D) their healthy siblings (S). secondary evaluate impact vitamin supplementation on these subsets.22 T1D 33 S were enrolled. Glucose, hemoglobin A1c, 25 OH (25[OH]D), T helper 17...
Hepatitis C virus (HCV) infection natural history and management in the pediatric population are still debated. We retrospectively evaluated outcome of a HCV managed at Pediatric Infectious Disease Unit Luigi Sacco Hospital (Milan, Italy) from January 1997 to 2022 (median follow-up 10 years) we focused on role new drugs transient elastography. Fifty-seven patients were enrolled: 8 (14%) had spontaneous clearance, 33 treated (58%), 7 (12%) not because they under 12 years old 9 lost follow-up....
Abstract Purpose To compare the clinical severity of Human Adenovirus (HAdV) infection with other viral diseases in a cohort children, evaluating presentation, therapy, and outcome. Methods We conducted retrospective multicenter study Italian children hospitalized from January to December 2023 for respiratory symptoms. The included HAdV presenting primarily Patients isolated gastrointestinal involvement or coinfection bacteria were excluded. Results A total 171 enrolled: 98 (age 44.3 ± 37.9...
Vitamin D and ω-3 fatty acids (ω-3) co-supplementation potentially improve type 1 diabetes (T1D) by attenuating autoimmunity counteracting inflammation.This cohort study preliminary to a randomized control trial (RCT) is aimed evaluate, in series of T1D children assuming Mediterranean diet taking cholecalciferol 1000U/day fromT1D onset, if preserves the residual endogen insulin secretion (REIS).Therefore, 22 new onsets 2017 received [eicosapentenoic acid (EPA) plus...
Coronavirus disease 19 (COVID-19) is clinically less severe in children, even if the wide variety and degree of severity symptoms reported children pose a still-unresolved challenge for clinicians. We performed an in-depth analysis immunological profiles 18 hospitalized SARS-CoV-2-infected whose results were compared to those obtained from 13 age- sex-matched healthy controls (HC). The patients categorized as paucisymptomatic/moderate (55.6%) or severe/critical (44.5%) according established...
Congenital cytomegalovirus infection (cCMV) is the most common congenital viral infection, with a consistent rate of morbidity, mortality, and long-term sequelae, especially in case late diagnosis. Nevertheless, universal screening for CMV not currently recommended, global awareness about this as well accurate shared indications on follow-up treatment, are still lacking. We reviewed data 59 suspect cCMV cases who referred to our center from 2014 2021. report 41 confirmed diagnosed at birth,...
Abstract On January 7, 2020, a novel coronavirus (SARS‐CoV‐2) was identified as the causative agent of cluster pneumonia unknown origin detected in Wuhan City by Chinese authorities. Since SARS‐CoV‐2 discovery, corresponding disease (COVID‐19) has rapidly expanded throughout globe, making consequence World Health Organization (WHO) declaring pandemic. As May 19, over 4.806.299 cases COVID‐19 had been confirmed worldwide, with more than 318.599 deaths.
ABSTRACT Background & Aims Glecaprevir/Pibrentasvir (GLE/PIB) has been approved by the European Medicine Agency (EMA) and US Food Drug Administration (US‐FDA) for treatment of children adolescents from 3 years age with chronic hepatitis C virus (CHC) infection. The aim this study was to confirm real‐world effectiveness safety GLE/PIB in (3 < 18 old) CHC. Methods This prospective, multicentre involved 11 Italian centres. Children (from age) received a weight‐based dose (up 300/120 mg)...