A5100322752- Spine and Intervertebral Disc Pathology
- Bone and Joint Diseases
- Spinal Fractures and Fixation Techniques
- Bone health and osteoporosis research
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Tendon Structure and Treatment
- Foot and Ankle Surgery
- Orthopaedic implants and arthroplasty
- Scoliosis diagnosis and treatment
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Body Composition Measurement Techniques
- MicroRNA in disease regulation
- Total Knee Arthroplasty Outcomes
- Autophagy in Disease and Therapy
- Periodontal Regeneration and Treatments
- RNA modifications and cancer
- Sports injuries and prevention
- Lymphoma Diagnosis and Treatment
Tianjin Hospital
2016-2025
Affiliated Hospital of Qingdao University
2015-2025
Qingdao University
2015-2025
Hebei Medical University
2010-2025
Ningbo Kangning Hospital
2025
Ningbo University
2025
The University of Tokyo
2025
Third Hospital of Hebei Medical University
2010-2025
University of Delaware
2013-2024
Fudan University
2008-2024
Abstract Some compositional and structural features of mature bone mineral particles remain unclear. They have been described as calcium-deficient hydroxyl-deficient carbonated hydroxyapatite in which a fraction the PO 4 3− lattice sites are occupied by HPO 2− ions. The time has come to revise this description since it now proven that surface is not form but rather hydrated amorphous calcium phosphate. Using combination dedicated solid-state nuclear magnetic resonance techniques,...
Prospective, randomized, controlled, multicenter clinical trial.To compare outcomes of cervical disc arthroplasty with those anterior decompression and fusion (ACDF) in a Chinese population.Cervical has been found to be superior ACDF for maintaining range motion (ROM) at the index spinal segment possibly will avoid abnormal stress adjacent segments.A total 120 patients from 3 large hospitals China were randomly assigned treatment (n = 60) using BRYAN prosthesis or observed postoperatively 24...
Purpose . This study was to report the clinical use of biomimetic nanohydroxyapatite/polyamide 66 (n‐HA/PA 66) mesh cages in anterior cervical corpectomy and fusion (ACCF) surgery. Method 95 patients who underwent single level for spondylosis myelopathy (CSM) our hospital were reviewed divided into 2 groups according using cage titanium (TMC). Demographic data surgical, clinical, radiological before operation at last follow‐up collected compared. Result The time, surgical blood loss,...
Abnormal angiogenesis is one of the significant features in periodontitis leading to progressive inflammation, but angiogenic changes periodontal ligaments under inflammatory condition were rarely reported. Periodontal ligament stem cells (PDLSCs) a kind dental associated with vascularization. Here we investigated alteration periodontitis, and revealed an exosome-mediated pathway support effect PDLSCs on improvement. Vascular specific marker CD31 VEGFA found be highly expressed...
Low back pain (LBP) is one of the top three causes disability in developed countries, and intervertebral disc degeneration (IDD) a major contributor to LBP. In process IDD, there gradual decrease nucleus pulposus cells (NPCs) extracellular matrix (ECM). Exosomes are important exocrine mediators stem that can act directly on for tissue repair regeneration. this study, we determined antisenescence, cell proliferation promotion, ECM modulation effects human urine-derived (USC) exosomes...
Phosphogypsum (PG) is a solid waste produced from decomposition of phosphate rock in sulfuric acid. It can improve the physicochemical properties soil. However, application PG will inevitably change living environment soil microorganisms and lead to evolution microbial community. The effects (0, 0.01%, 0.1%, 1%, 10% PG) on respiration, enzyme activity community were studied systematically by indoor incubation experiments. results showed that addition 0.01% had little effect microflora....
Abstract The proteasome plays a pivotal role in protein degradation, and its impairment is associated with various pathological conditions, including neurodegenerative diseases. It well understood that Nrf1 coordinates the induction of all genes response to dysfunction. However, molecular mechanism regulating basal expression remains unclear. Here we identify transcription factor THAP1, causative gene DYT6 dystonia, as regulator activity through genome-wide genetic screen. We demonstrated...
The present study aimed to investigate the expression of CYP27A1, CYP7B1, insulin-like growth factor-1 (IGF-1), glucose-6-phosphate-dehydrogenase (G6PD), glutathione S-transferase P1 (GSTP1), and pyruvate kinase isoform M2 (PKM2) in breast carcinoma tissue evaluate their prognostic value for progression-free survival (PFS) overall (OS). A total 20 patients treated with surgery primary were enrolled: 10 cases diagnosed recurrent metastasis (A), along corresponding metastases specimen (AM) no...
Objective. This study is aimed at determining the effects of human urine-derived stem cell-derived exosomes (USCs-exos) on pressure-induced nucleus pulposus cell (NPC) apoptosis and intervertebral disc degeneration (IDD) ERK AKT signaling pathways. Methods. The NPCs were obtained from patients with herniated lumbar discs. Western blot analysis (WB) quantitative real-time polymerase chain reaction (qRT-PCR) used to determine endoplasmic reticulum (ER) stress levels under stress. Human USCs...
Physiotherapy is one of the effective treatments for tendinopathy, whereby symptoms are relieved by changing biomechanical environment pathological tendon. However, underlying mechanism remains unclear. In this study, we first established a model progressive tendinopathy-like degeneration in rabbit Achilles. Following ex vivo loading deprivation culture bioreactor system 6 and 12 days, tendons exhibited degenerative changes, abnormal collagen type III production, increased cell apoptosis,...
Traumatic brain injury (TBI) can cause the pathological disruption of blood-brain barrier (BBB) and associated neurological injury. Reducing severity such following TBI decrease degree edema, suppress intracranial inflammation, thereby protect against damage. The BBB is made up microvascular endothelial cells (BMVECs), neurons, pericytes, astrocytes, extracellular matrix components. In prior analyses, we have demonstrated that miR-124-3p expression enhanced in microglia-derived exosomes TBI,...
Osteosarcoma is the most common primary bone malignancy in children and young adults, but role of adipose-derived mesenchymal stem cells (ADSCs) rapid progression osteosarcoma still unclear. Here, we found that ADSCs promoted tumour growth invasion by increasing matrix metalloproteinase 2/9 (MMP2/9) expression cells. The persistent activation signal transducer activator transcription 3 (STAT3) has been shown to directly promote mediating a wide spectrum cellular responses, STAT3 was detected...
Magnesium metal and its alloys are being developed as effective orthopedic implants; however, the mechanisms underlying actions of magnesium on bones remain unclear. Cystic fibrosis, most common genetic disease in Caucasians caused by mutation CFTR, has shown bone disorder a key clinical manifestation, which currently lacks therapeutic options. Here we report that implantation magnesium-containing implant stimulates formation improves fracture healing CFTR-mutant mice. Wnt/β-catenin...
Although intervertebral disc degeneration (IDD) can be described as different stages of change through biological methods, this long and complex process cannot defined in by single or simple combination techniques. Under the background development nuclear magnetic resonance (NMR) technology emerging metabonomics, we based on animal models expanded to study clinical human models. The characteristics IDD were analyzed omics. Omics imaging combined with histology, cytology, proteomics was used...
Sarcopenia, an age-related complication, constitutes a major public health problem given the aging of population. However, it is frequently overlooked and undertreated in mainstream practice. The study aimed to investigate correlations between triglyceride-glucose (TyG) index TyG-body mass (BMI) sarcopenia non-diabetic middle-aged older women whether they would be helpful indicators sarcopenia. This cross-sectional was conducted Department Endocrinology, Hebei Medical University Third...
The advent of O-arm navigation optimized the oblique lumbar interbody fusion (OLIF) procedure, allowing operator to simultaneously perform OLIF and percutaneous posterior pedicle screw implantation without patient position change, thus improving fluency accuracy procedure (called as OLIF360). Nevertheless, a consensus regarding its suitability for patients with severe spinal stenosis remains elusive. This study aims investigate clinical efficacy OLIF360 imaging changes in cases....
Objectives: To establish and validate a sensitive robust gas chromatography–mass spectrometry (GC–MS) method for the quantification of β‐elemene in human plasma assess correlation between antitumor effect concentration vivo . Methods: The chromatographic column was HP‐5 ms (30 m × 0.25 mm, μm, Agilent, United States America). carrier helium (purity > 99.5%). flow rate 1.0 mL/min total run time 11.0 min. sample pretreated with protein precipitation plus liquid–liquid extraction. Cancer...
Dance style recognition through video analysis during university training can significantly benefit both instructors and novice dancers. Employing in offers substantial advantages, including the potential to train future dancers using innovative technologies. Over time, intricate dance gestures be honed, reducing burden on who would, otherwise, need provide repetitive demonstrations. Recognizing dancers’ movements, evaluating adjusting their gestures, extracting cognitive functions for...