A5057845695- Corneal Surgery and Treatments
- Protease and Inhibitor Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Salivary Gland Disorders and Functions
- Developmental Biology and Gene Regulation
- Cancer, Lipids, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Corneal surgery and disorders
- Pancreatic function and diabetes
- Connective tissue disorders research
- Protein Kinase Regulation and GTPase Signaling
- Renal Diseases and Glomerulopathies
- Hippo pathway signaling and YAP/TAZ
- Ocular Surface and Contact Lens
- Long-Term Effects of COVID-19
- Connexins and lens biology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Atherosclerosis and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Laser Applications in Dentistry and Medicine
- Caveolin-1 and cellular processes
- Aortic aneurysm repair treatments
- Blood Coagulation and Thrombosis Mechanisms
- Skin Protection and Aging
Linköping University
2017-2025
Academy of Athens
2011-2021
Biomedical Research Foundation of the Academy of Athens
2017-2021
National and Kapodistrian University of Athens
2012-2016
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disease considered to be triggered by viral infections in majority of cases. Symptoms overlap largely with those post-acute sequelae COVID-19/long-COVID implying common pathogenetic mechanisms. SARS-CoV-2 infection risk factor for sustained latent virus reactivation that may account the symptoms post-viral syndromes. The aim this study was first investigate whether patients ME/CFS and healthy donors (HDs)...
In cases of blinding disease or trauma, hydrogels have been proposed as scaffolds for corneal regeneration and vehicles ocular drug delivery. Restoration transparency, augmenting a thin cornea postoperative delivery are particularly challenging in resource-limited regions where availability patient compliance may be suboptimal. Here, we report bioengineered hydrogel based on porcine skin collagen an alternative to human donor tissue applications long-term stability the is required. The...
Liraglutide, a human long-lasting GLP-1 analogue, is currently regarded as powerful treatment option for type 2 diabetes. Apart from glucoregulatory and insulinotropic actions, liraglutide increases β-cell mass through stimulation of proliferation islet neogenesis, well inhibition apoptosis. However, the underline molecular mechanisms have not been fully characterized. In this study, we investigated mechanism by which preserves β-cells in an animal model overt diabetes, obese db/db mice,...
Physical exercise is the cornerstone of cardiovascular disease treatment. The present study investigated whether training affects atherosclerotic plaque composition through modification inflammatory-related pathways in apolipoprotein E knockout (apoE(-/-)) mice with diabetic atherosclerosis. Forty-five male apoE(-/-) were randomized into three equivalent (n=15) groups: control (CO), sedentary (SED), and (EX). Diabetes was induced by streptozotocin administration. High-fat diet administered...
<b><i>Background:</i></b> Atherosclerosis is the major cause of cardiovascular disease; hypercholesterolemia a risk factor. We hypothesized that specific TLR members (TLR2, TLR3, TLR4, TLR8) may play role in atherosclerosis progression and its accompanying inflammatory response. determined association atherosclerotic lesions mRNA expression different aortic sites. also assessed effects fluvastatin (Flu) treatment on plaque characteristics....
Abstract Congenital aniridia is a rare eye disease characterized by loss of PAX6 protein leading to aniridia-associated keratopathy that significantly reduces vision. The miR-204-5p possible regulator function and here we evaluate its effect in multiple vitro vivo models. In vitro, overexpression suppressed vascular factor ANGPT1 human limbal stem cells (T-LSC) Pax6-knockdown LSC (mut-LSC), primary epithelial (LEC) at the gene levels following LPS stimulation. However, inhibited VEGFA...
Aims: The GROSSO® implant is an ophthalmic medical device designed to reshape the ectatic cornea. primary aim of this study assess for first time surgical implantation and safety in vivo a preclinical done rabbits. Methods: A 9‐9.5mm diameter circular corneal pocket located at 2/3 minimum thickness was created by femtosecond laser right eye only. In 8 control eyes manually separated while group with 12 eyes, inserted through access cut being folded 6‐0 vicryl suture. After insertion...
<i>Aim:</i> To investigate the effects of exercise on atherosclerotic plaque composition, concentration matrix metalloproteinases (MMPs) in and systemic circulation. <i>Methods:</i> Ninety apolipoprotein E-deficient (apoE<sup>–/–</sup>) mice (45 male) were randomized to following groups (n = 15 each): control male/female; sedentary male/female. Mice kept a 16-week high-fat diet. Subsequently, sacrificed, while rest animals placed normal diet for 6 more...
Aim This study aimed to investigate the effects of combined atorvastatin and exercise treatment on composition stability atherosclerotic plaques in apolipoproteinE (apoE) knockout mice. Methods Forty male, apoE−/− mice were fed a high-fat diet for 16 weeks. Thereafter, while maintained diet, they randomized into four (n = 10) groups 8 additional weeks: Group CO: Control. AT: Atorvastatin (10 mg/Kg/day). EX: Exercise-training treadmill. AT+EX: simultaneous training. At study's end, plasma...
Nephrin, a cell surface signaling receptor, regulates podocyte function in health and disease. We study the role of nephrin β-cell survival signaling. report that mouse islet β-cells pancreatic beta-cell line (βTC-6 cells) is associated partly co-localized with PI3-kinase. Incubation cells functional anti-nephrin antibodies induced clustering at plasma membrane, phosphorylation recruitment PI3-kinase to thus resulting increased PI3K-dependent Akt augmented phosphorylation/inhibition...
Objective Sjögren's syndrome (SS) is a chronic autoimmune disorder that affects mainly the exocrine glands. Endoplasmic reticulum (ER) stress proteins have been suggested to participate in and inflammatory responses, either acting as autoantigens, or by modulating factors of inflammation. The chaperone protein ERdj5 an ER resident disulfide reductase, required for translocation misfolded during associated degradation. In this study we investigated role salivary glands (SGs), association with...
PAX6 is a key regulator of eye development and epithelial homeostasis in the cornea. When deficient, chronic corneal inflammation, neovascularization limbal stem cell deficiency can occur. Here we investigated potential duloxetine, generic serotonin reuptake inhibitor that upregulate vitro, for its vivo activity context inflammation.
We investigated the effect of combining exercise training and treatment with an endocannabinoid receptor 1 inhibitor (Rimonabant) on atherosclerosis burden composition. Forty-eight apolipoprotein E-deficient (ApoE-/-) mice were kept a 16-week high-fat diet. Mice then placed normal diet randomized to following groups n = 12 for 6 more weeks: 1) Control (Co) - no intervention; 2) Exercise (Ex) treadmill; 3) Rimonabant (Ri) oral administration rimonabant (10 mg/kg/day); or 4)...
The purpose of this study was to identify differentially expressed proteins in salivary glands the ERdj5 knockout mouse model for Sjögren's syndrome and elucidate possible mechanisms morbid phenotype development. At same time, we describe first time sexual dimorphism murine submandibular gland at proteome level. We performed Liquid Chromatography/Mass Spectrometry tissues from both sexes 129SV wildtype mice. resulting list evaluated with bioinformatic analysis selected were validated by...
Aniridia is a rare congenital condition of abnormal eye development arising principally from heterozygous mutation the PAX6 gene. Among multiple complications in eye, aniridia-associated keratopathy (AAK) severe vision-impairing cornea associated with progressive limbal stem cell deficiency that lacks suitable treatment options. Current mouse models aniridia do not accurately represent onset and progression dynamics human AAK, hindering therapy development. Here, we performed deep...
<h3>Background/objective</h3> Sjögren's Syndrome (SS) is a chronic autoimmune disorder that mainly affects the exocrine glands, with largely unknown initiation and causative agents. Endoplasmic Reticulum (ER) stress proteins have been suggested to participate in inflammatory responses, either by acting as autoantigens themselves, or modulating factors responses. ERdj5 an ER-resident chaperone protein disulfide reductase activity, required for translocation of misfolded across ER proteasomal...