Polycystic ovary syndrome (PCOS) is an endocrinal disorder that afflicts mainly women of childbearing age. The symptoms PCOS are irregular menstrual cycles, weight gain, subfertility and infertility. However, because the etiology unclear, management treatment methods for not well established. Recently, natural substances have been used therapy. Ecklonia cava (E. cava) a well-known substance attenuates effects inflammation, allergies cancer. In this study, we investigated E. extract in rats...

Licorice (Glycyrrhizae radix et rhizome, GRR) has long been used as an ingredient in Korean traditional medicinal herbal formulas for various metabolic and reproductive diseases. Polycystic ovary syndrome (PCOS) is a common endocrine disorder premenopausal women. In the present study, we examined effects of GRR extract on PCOS-like symptoms female rats. Symptoms PCOS were induced by Letrozole treatment 4 weeks 6-week-old SD rats, after which recovery normal hormonal levels polycystic ovaries...

Allergic rhinitis (AR), a chronic respiratory inflammatory disease, is among the most common diseases reported worldwide. Mucus hypersecretion critical feature of AR pathogenesis. Although Gleditsia sinensis extract has several beneficial effects on human health, its allergic inflammation have not yet been investigated. In this study, we examined G. aqueous (GSAE) nasal in an ovalbumin (OVA)-induced mouse model. GSAE was administered orally for 1 week and then clinical symptoms were...

ABSTRACT Background Regulatory T cells (Tregs) are living drugs with feasibility, tolerability, and therapeutic benefits. Although Tregs linked to asthma prognosis through inflammation regulation, no agents specifically designed manage by upregulating have been developed date. Methods We screened a library of 250 natural products using cytometric bead array. Among the selected candidates, gRb1 was identified for further investigation. The effects on Treg Th17 populations were evaluated in...

Allergic rhinitis (AR) is a common chronic respiratory disease. Asarum heterotropoides (AH) predicted to be treatment for allergic diseases, but its therapeutic effect unclear. We aimed determine the anti-allergic effects of AH in mice with ovalbumin (OVA)-induced AR. OVA-induced AR mouse model was constructed, and orally administered week; next, nasal clinical symptoms were evaluated. The levels serum histamine, OVA-specific IgE, IL-13 measured by ELISA. Inflammatory cells, including...

Allergic rhinitis (AR), caused by immunoglobulin E (IgE)-mediated inflammation, generally occurs in the upper respiratory tract. T helper type 2 (Th2) cell-mediated cytokines, including interleukin (IL)-4, IL-5, and IL-13, are important factors AR pathogenesis. Despite various treatment options, difficulty alleviating pharmacological side effects necessitate development of new therapies. The root Pulsatilla koreana Nakai (P. koreana), a pasque flower, has been used as herbal medicine....

Allergic rhinitis (AR) is a well-documented type 2 helper T (Th2) cell-mediated allergic disease that accompanied by symptoms such as nasal rubbing, sneezing, itching, and rhinorrhea. Angelica gigas (AG) traditional oriental medicine, its dried root widely used for the treatment of anemia, sedative, blood tonic.The effects AG on diseases including AR are currently unclear; therefore, we aimed to investigate extract (AG-Ex) in ameliorating AR.The cytotoxicity AG-Ex was analyzed EZ-Cytox or...

Abstract Increasing efforts are being made to develop more sensitive and faster molecular methodologies at the genomic proteomic levels for identification of protein markers after exposure ionizing radiation (IR). However, few specific markers, especially organ‐specific have been identified. In this study, we analyzed altered expressions in various tissues, namely, brain, lung, spleen, intestine, from 1 Gy‐irradiated mice by employing 2‐DE analysis. MALDI‐TOF MS peptide mapping identified 25...

Tetragonia tetragonioides (Pall.) Kuntze (TTK) is a medicinal plant traditionally used to treat various diseases such as diabetic, inflammatory, and female-related disorders. Polycystic ovary syndrome (PCOS) common endocrinological disorder in women of reproductive age, hyperandrogenism prominent feature PCOS resulting anovulation infertility. In this study, we investigated the effects TTK extract on androgen generation regulation steroidogenic enzymes vitro vivo. Human adrenocortical...

Allergic rhinitis (AR) is a common upper-airway inflammatory disease of the nasal mucosa caused by immunoglobulin (IgE)-mediated inflammation. AR causes various painful clinical symptoms that worsen quality daily life, necessitating urgent development therapeutic agents. Herein, we investigated effects Caesalpinia sappan Linn. heartwood water extract (CSLW), which has anti-inflammatory and antioxidant properties, on AR-related responses. We examined anti-allergic CSLW in ovalbumin...

• Cirsium japonicum (CSJ) alleviates ovalbumin (OVA)-induced allergic rhinitis (AR) CSJ reduces serum anti-OVA IgE, histamine, and IL-13 levels nasal inflammation O-Linked glycosylation of mucins, MUC5AC, NRF2 are key targets in AR Cryptochlorogenic acid cirsimarin bind directly to NRF2–KEAP1 MUC5AC shows potential for therapeutic agent via the pathway expression regulation

Radiation-induced intestinal toxicity is common among cancer patients after radiotherapy. Endothelial cell dysfunction believed to be a critical contributor radiation tissue injury in the intestine. Geranylgeranylacetone (GGA) has been used treat peptic ulcers and gastritis. However, protective capacity of GGA against radiation-induced not addressed. Therefore, we investigated whether affects damage mice vascular endothelial vitro. treatment significantly ameliorated injury, as evident by...

The loss of retinal pericytes is one the earliest changes associated with diabetic retinopathy (DR). Chronic hyperglycemia induces apoptosis these cells, leading to onset and progression DR. In this study, we investigated effects Homonoia riparia (H. riparia) its major component, myricitrin, on high glucose (HG)-induced primary human (HRPs).The an ethanol extract H. leaves myricitrin HRP viability were by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay flow...

Pueraria lobata is used in traditional Asian medicine to treat cardiovascular diseases, diarrhea, diabetes mellitus, and diabetic complications such as retinopathy. Oxidative stress retinal pigment epithelial cells implicated the pathogenesis of retinopathy age-related macular degeneration (AMD). Here, we evaluated whether P. extract can prevent cell death decrease membrane permeability oxidative stress-induced human cells.The effects on hydrogen peroxide- (H2O2-) induced were investigated...

Background Osteomeles schwerinae C. K. Schneid. (Rosaceae, OSSC) is a medicinal plant traditionally used to treat various diseases in Asia. The chemical constituents of OSSC have an inhibitory effect on aldose reductase activity, which has been implicated the pathogenesis diabetic complications. However, protective effects pharmacological activity and potential mechanisms nephropathy are still not known. Objective In present study we investigated that extracts major compounds were examined...

The accumulation and formation of advanced glycation end products (AGEs) are related to diabetes age-related disease.

Allergic rhinitis (AR) is a chronic inflammatory condition affecting the nasal mucosa of upper airways. Herein, we investigated effects extracts from Gardenia jasminoides (GJ), traditional herbal medicine with anti-inflammatory properties, on AR-associated responses that cause epithelial damage. We inhibitory water- and ethanol-extracted GJ (GJW GJE, respectively) in an ovalbumin-induced AR mouse model splenocytes, differentiated Th2 cells, primary human cells (HNEpCs). Administering GJW GJE...

Tetragonia tetragonoides (Pall.) Kuntze (TTK) is a groundcover found along coastal areas of the Korean peninsula. TTK traditionally used to improve women's health and treat gastrointestinal diseases. Use herbal medicines in treatment mood disorders has recently been suggested as an alternative therapeutic strategy. In present study, we determined that consumption extract ameliorated progression depressive-like symptoms ovariectomized (OVX) rats further examined mechanisms involved, i.e.,...

Aromatase, a cytochrome P450 enzyme that converts androgens into estrogens, is an important drug target for hormone-dependent diseases. The purpose of this study was to elucidate the aromatase inhibitory effects Ma-Huang-Tang (MHT), traditional Korean herbal medicine prescription, and identify its active ingredients. In study, effect MHT on activity observed using dibenzylfluorescein (DBF) KGN cells, dose-dependent verified (IC50 values 251 μg/mL 246 as determined by two methods,...

Methylglyoxal (MG) is one of uremic toxins produced by glycolysis that may results in diabetic nephropathy. In this study, we investigated the effect and mechanism MG on apoptosis podocytes. Conditionally immortalized podocytes for differentiation were induced culturing cells at 37°C 13~15 days treated with various concentration (0, 50,100, 200, 400 μM). Our data show a decrease cell viability dose‐dependent manner increased formation dichlorofluorescein (DCF)‐sensitive intracellular...

Abstract Angiogenesis, the recruitment of new blood vessels is a crucial mechanism required for both tumor growth and metastasis. Vascular endothelial factor (VEGF) its receptors, particularly VEGF receptor 2 (VEGFR2, or kinase insert domain-containing receptor, KDR), play critical role in tumor-associated angiogenesis. Monoclonal antibodies (mAb), due to their high specificity towards given target, represent unique class novel therapeutics as angiogenesis inhibitors. We developed TTAC-0001,...

Supplementary Figures 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via Direct Inhibition of Src Kinase Activity