A5102996967- Gut microbiota and health
- Inflammatory Bowel Disease
- Probiotics and Fermented Foods
- Soil Carbon and Nitrogen Dynamics
- Clostridium difficile and Clostridium perfringens research
- Microbial Community Ecology and Physiology
- Pancreatitis Pathology and Treatment
- Soil and Water Nutrient Dynamics
- Helicobacter pylori-related gastroenterology studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Nephrotoxicity and Medicinal Plants
- Syphilis Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Autophagy in Disease and Therapy
- Gastrointestinal motility and disorders
- Scientific Computing and Data Management
- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Mycorrhizal Fungi and Plant Interactions
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Reproductive tract infections research
- Peatlands and Wetlands Ecology
South China University of Technology
2021-2025
Guangzhou Medical University
2021-2025
Guangzhou First People's Hospital
2021-2025
State Key Joint Laboratory of Environment Simulation and Pollution Control
2022-2024
Tsinghua University
2022-2024
Research Center for Eco-Environmental Sciences
2024
Sir Charles Gairdner Hospital
1999
UNSW Sydney
1999
Abstract Forest soils contain a large amount of organic carbon and contribute to terrestrial sequestration. However, we still have poor understanding what nutrients limit soil microbial metabolism that drives release across the range boreal tropical forests. Here used ecoenzymatic stoichiometry methods investigate patterns nutrient limitations within profiles (organic, eluvial parent material horizons) 181 forest sites throughout China. Results show that, in 80% these forests, microbes were...
Abstract Background Dextran sulfate sodium (DSS) replicates ulcerative colitis (UC)-like in murine models. However, the microbial characteristics of DSS-triggered require further clarification. To analyze changes gut microbiota associated with DSS-induced acute and chronic colitis. Methods Acute was induced mice by administering 3% DSS for 1 week drinking water, supplementing water 2.5% every other 5 weeks. Control groups received same without supplementation. The histopathological score...
Abstract Background Anthropogenic activities have increased the inputs of atmospheric reactive nitrogen (N) into terrestrial ecosystems, affecting soil carbon stability and microbial communities. Previous studies primarily examined effects deposition on taxonomy, enzymatic activities, functional processes. Here, we various traits communities how these are interrelated in a Mediterranean-type grassland administrated with 14 years 7 g m −2 year −1 N amendment, based estimated areas within...
Abstract An increasing number of studies have shown that Faecalibacterium prausnitzii ( F. ) is a promising anti-inflammatory bacterium colonizes in the gut and microbiota dysbiosis plays an important role pathogenesis inflammatory bowel disease (IBD). In this study, we report profile 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis mice treated with its supernatant on basis high-throughput sequencing. We interestingly found both metabolites exerted protective effects against mice,...
Abstract —Despite intense investigation, mechanisms linking the development of occlusive vascular disease with elevated levels homocysteine (HCY) are still unclear. The endothelium plays a key role in regulating thrombogenesis and thrombolysis. We hypothesized that lesions individuals plasma HCY may be related to dysfunction triggered by HCY. investigated effect on human neutrophil adhesion migration through endothelial monolayers. also examined leukocyte mesenteric venules anesthetized...
Autophagy and gut microbiota correlates closely with the inflammatory bowel disease. Herein, we aimed to study roles of rapamycin on in disease.Acute colitis was induced dextran sodium sulfate (DSS) 2,4,6-trinitrobenzenesulfonic acid solution mice. Mice were administered or hydroxychloroquine. Weight loss, disease activity index scores, histopathological score, serum cytokines, intestinal permeability, colonic autophagy-related proteins detected. Cecal content also preserved liquid nitrogen...
ABSTRACT Background and Aim Peroxisome proliferator–activated receptors (PPARs), as nuclear receptors, modulate both lipid metabolism inflammatory/immune processes. This study examines the impact of modulating activities PPAR subtypes PPARβ/ð PPARγ on gut microbiota in inflammatory bowel disease (IBD). Methods Mice with dextran sulfate sodium (DSS)–induced acute colitis were treated agonist pioglitazone, PPARβ/δ GW0742, or their respective antagonists (GW9662, GSK3787). Weight loss, diarrhea...
Abstract Background Probiotics are a potentially effective therapy for inflammatory bowel disease (IBD); IBD is linked to impaired gut microbiota and intestinal immunity. However, the utilization of an antibiotic cocktail (Abx) prior probiotic intervention remains controversial. This study aims identify effect Abx pretreatment from dextran sulfate sodium (DSS)-induced colitis evaluate whether has enhanced on protection Clostridium butyricum Miyairi588 (CBM) colitis. Results The inflammation,...
Plant-derived exosome-like nanoparticles (PELNs) have received widespread attention in treating ulcerative colitis (UC). However, the role of Houttuynia cordata-derived (HELNs) UC remains unclear. This study aims to evaluate efficacy HELNs mice and investigate its potential mechanisms. were isolated from H. cordata for characterization, their safety stability evaluated. A dextran sulfate sodium (DSS)-induced mouse model was utilized assess therapeutic UC. In vivo, imaging flow cytometry...
Abstract Soils in forested ecosystems are extremely heterogeneous and represent a critical component of terrestrial ecosystems. Despite their substantial ecological value, the geographic characteristics, processes, coexistence microbial communities forest soils remain poorly understood. Here, we investigated biodiversity dynamics, environmental influences, community assembly, co‐occurrence patterns bacterial fungal surface subsurface across 47 Chinese sites. The biogeographic characteristics...
<h3>Background</h3> Gut microbiota is necessary for the development of Inflammatory bowel disease (IBD), and IgA-coated bacteria correlated with susceptibility to colitis. Screening immune-responsive taxa according IgA coating crucial therapeutic target prognosis prediction IBD. We found that <i>Odoribacter. splanchnicus</i> (O.s) can be coated by explore relevance O.s colitis immune-related mechanism. <h3>Methods</h3> The relative abundance was confirmed IgA-seq in a UC cohort before after...
<h3>Background</h3> The prevalence of inflammatory bowel disease (IBD) has been on the rise in developing countries. However, mechanism interaction between gut microbiota and immunity, especially how probiotics regulate imbalance mucosal immunity IBD, remains unclear. Hence, this study aims to explore role <i>Clostridium butyricum</i> (<i>C. butyricum</i>) M2 macrophage-mediated intestinal barrier injury repairation regarding efferocytosis. <h3>Methods</h3> <i>C. was treated DSS-induced...
Ureaplasma spp. can be classified into different serovars. It is unknown whether distinct serovars are associated with clinical signs and symptoms.
<h3>Background</h3> There is a decrease in probiotic bacteria, especially the depletion of short-chain fatty acids (SCFAs)-producing bacteria Inflammatory bowel diseases (IBD). Although intestinal have been identified to alleviate colitis, however, efficacy mixed SCFAs-producing inflammatory patients remains unclear. <h3>Methods</h3> We used reasonable approach isolate and culture several from feces healthy donors. The objective this study was compare effects 7-mixed supernatant, human FMT...
<h3>Background</h3> Bacillus amyloliquefaciens (BA) decomposes starch by producing alpha-amylase to produce short-chain fatty acids (SCFA). Resistant (RS) can be fermented colonic microbiota and metabolized SCFA containing acetic acid butyric which ameliorate intestinal inflammation. In this study, dextran sulfate sodium (DSS)-induced colitis mouse model was administrated assess the therapeutic effect of BA combined with RS in experimental colitis. <h3>Methods</h3> 6-week-old male BALB/c...
<h3>Background</h3> Inflammatory bowel disease is a chronic inflammatory characterized by recurrent abdominal pain and diarrhea, gut microbiota one of its causes. Probiotics, as the intervention methods microbiota, play an important role in treatment. This study aims to observe effect immune mechanism Clostridium butyricum MIYAIRI 588 (CBM) it's supernatant on colitis mice which pretreated with antibiotic cocktail (ABx). <h3>Methods</h3> Twenty four Balb/c aged 6-8 weeks were randomly...