A5061368916- French Urban and Social Studies
- Malaria Research and Control
- Mosquito-borne diseases and control
- Social Policies and Family
- Aging, Elder Care, and Social Issues
- Healthcare Systems and Practices
- Agriculture and Rural Development Research
- Social Sciences and Governance
- Hepatitis C virus research
- Global Maternal and Child Health
- Vaccine Coverage and Hesitancy
- International Maritime Law Issues
- Law, logistics, and international trade
- Child Nutrition and Water Access
- Complement system in diseases
- Global Energy and Sustainability Research
- Brucella: diagnosis, epidemiology, treatment
- Criminal Law and Evidence
- Parasitic Diseases Research and Treatment
- Comparative and International Law Studies
- Land Rights and Reforms
- Ombudsman and Human Rights
- Conflict of Laws and Jurisdiction
- Allergic Rhinitis and Sensitization
- Tree Root and Stability Studies
Université des Sciences, des Techniques et des Technologies de Bamako
2016-2025
University of Bamako
2022-2023
Mali-Folkecenter
2023
Université de Reims Champagne-Ardenne
2008-2020
Centre Pour le Développement des Vaccins-Mali
2018
Institut National de Recherche en Santé Publique
1993-2009
Yue Bei People's Hospital
2008
Shantou University
2008
Malaria control remains a challenge in many parts of the Sahel and sub-Sahel regions Africa.We conducted an individually randomized, controlled trial to assess whether seasonal vaccination with RTS,S/AS01E was noninferior chemoprevention preventing uncomplicated malaria two interventions combined were superior either one alone severe malaria-related outcomes.We randomly assigned 6861 children 5 17 months age receive sulfadoxine-pyrimethamine amodiaquine (2287 [chemoprevention-alone group]),...
<h2>Summary</h2><h3>Background</h3> Seasonal vaccination with the RTS,S/AS01<sub>E</sub> vaccine combined seasonal malaria chemoprevention (SMC) prevented in young children more effectively than either intervention given alone over a 3 year period. The objective of this study was to establish whether added protection provided by combination could be sustained for further 2 years. <h3>Methods</h3> This double-blind, individually randomised, controlled, non-inferiority and superiority, phase...
In sub-Saharan Africa, in particular rural areas, patients have limited access to doctors with specialist skills skin diseases. To address this issue, a teledermatology pilot programme focused on primary health centres was set up Mali. This study aimed at investigating the feasibility of and its impact management The based store-and-forward model. Health care providers from 10 were trained manage common diseases, capture images lesions, use an e-platform post all cases beyond their expertise...
Background The R21/Matrix-M malaria vaccine has been shown to provide high protective efficacy against in a phase III trial, and recommended for use by WHO. will soon be deployed at scale sub-Saharan Africa. This study aimed understand the caregiver community acceptability of alongside existing prevention interventions, according communities participants seasonal trial Mali. Methods Qualitative data were collected assess three or control priming injections given first year trial. A total 33...
Abstract The recently deployed RTS,S/AS01 E malaria vaccine induces a strong antibody response to the circumsporozoite protein (CSP) on surface of Plasmodium falciparum sporozoite which is associated with protection. anti-CSP titre falls rapidly after primary vaccination, decline in efficacy, but and protective can be partially restored by booster dose vaccine, this also transitory. In many malaria- endemic areas Africa, children are at risk malaria, including severe until they five years...
Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited information is available on the pharmacokinetic properties antimalarial drugs in this vulnerable population. We assessed artemether-lumefantrine (AL) clinical efficacy children SAM compared to those without. Children under 5 years age uncomplicated P. falciparum malaria were enrolled between November 2013 January 2015 Mali Niger, one third...
Abstract Background A recent trial of 5920 children in Burkina Faso and Mali showed that the combination seasonal vaccination with RTS,S/AS01 E malaria vaccine (primary series two boosters) chemoprevention (four monthly cycles per year) was markedly more effective than either intervention given alone preventing clinical malaria, severe deaths from malaria. Methods In order to help optimise timing these interventions, data were reanalysed estimate duration protection against provided by when...
Seasonal vaccination with the RTS,S/AS01
Objective: demonstrate the feasibility of deploying portable ultrasonography with remote assistance to improve diagnostic capabilities isolated physicians in Africa. Methods: approach is based on training general practitioners for use ultrasonography, and support by radiologists using dedicated tools image transfer over low-bandwidth internet connections. Results: our early results a pilot project Mali show that this feasible, can productively diagnosis management decisions such as need...
Background: Plasmodium falciparum (Pf) parasitemia during pregnancy causes maternal, fetal, and infant mortality. We conducted two trials in Ouélessébougou, Mali to optimize PfSPZ Vaccine dosage, schedule, antimalarial pre-treatment for future maternal immunizations.Methods: In MLSPZV3 trial (NCT03510481), we randomly assigned healthy 18-35-year-olds 3 doses of 9x105 (versus placebo) at 0,1,4-weeks or 0,8,16-weeks without pre-treatment, with 1-year booster dose. MLSPZV4 (NCT03989102),...
Background The WHO recommends use of the RTS,S/AS01 E (RTS,S) malaria vaccine for young children living in areas moderate to high Plasmodium falciparum transmission and suggests countries consider seasonal vaccination with highly malaria. Seasonal is uncommon may require adaptations potential cost consequences. This study prospectively estimates delivery Mali Burkina Faso. Methods Three scenarios are costed (1) mass campaign only, (2) routine Expanded Programme on Immunisation (EPI) (3)...
A trial in African children showed that combining seasonal vaccination with the RTS,S/AS01E vaccine malaria chemoprevention reduced incidence of uncomplicated and severe compared either intervention given alone. Here, we report on anti-circumsporozoite antibody response to this trial.Sera from a randomly selected subset collected before 1 month after 3 priming doses 2 booster were tested for antibodies using enzyme-linked immunosorbent assay. The association between post-vaccination titer...
Malaria has been hypothesized as a factor that may have reduced the severity of COVID-19 pandemic in sub-Saharan Africa. To evaluate effect recent malaria on we assessed subgroup individuals participating longitudinal cohort serosurvey were also undergoing intensive monitoring part antimalarial vaccine trials during 2020 transmission season Mali. These communities experienced high incidence primarily asymptomatic or mild and 2021. In 1314 individuals, 711 parasitemic season; 442 symptomatic...
The association between thrombocytopenia and parasite density or disease severity is described in numerous studies. In recent years, several studies the protective role of platelets directly killing Plasmodium parasites, mediated by platelet factor 4 (PF4) binding to Duffy antigen. This study aimed evaluate young children who are antigen-negative, such as those sub-Saharan Africa. A zero-inflated negative binomial model was used relate count data collected a longitudinal birth cohort....
Abstract Background A recent trial in Burkina Faso and Mali showed that combining seasonal RTS,S/AS01 E malaria vaccination with chemoprevention (SMC) substantially reduced the incidence of uncomplicated severe young children compared to either intervention alone. Given possible negative effect on nutrition, study investigated whether these also experienced lower prevalence acute chronic malnutrition. Methods In 5920 were randomized receive SMC alone, or combined for three transmission...
Les limitations administratives apportées aux modes d'utilisation des sols par le droit de l'urbanisme créent une situation d'hétéronomie juridique défavorable, a priori, au propriété immobilière. Présenté comme atteintes légales à la foncière, est généralement perçu ne pouvant et faisant que restreindre les attributs du propriété. Cette lecture orthodoxe omet finalités d'intérêt général poursuivies réglementation administrative compensations règles servitudes d'urbanisme procurent...