A5088021901- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Complement system in diseases
- Tuberculosis Research and Epidemiology
- Child Nutrition and Water Access
- Travel-related health issues
- Pneumonia and Respiratory Infections
- Global Maternal and Child Health
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Pregnancy and preeclampsia studies
- Mycobacterium research and diagnosis
- Computational Drug Discovery Methods
- Infectious Diseases and Tuberculosis
- Hepatitis C virus research
- Genetics, Bioinformatics, and Biomedical Research
- Venomous Animal Envenomation and Studies
- Diverse Scientific Research Studies
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- Maternal Mental Health During Pregnancy and Postpartum
- Rabies epidemiology and control
- Viral Infections and Outbreaks Research
- Blood Coagulation and Thrombosis Mechanisms
MRC Unit the Gambia
2020-2024
Université des Sciences, des Techniques et des Technologies de Bamako
2016-2024
Institut National de la Recherche Scientifique
2024
London School of Hygiene & Tropical Medicine
2023
Mali-Folkecenter
2023
University of Bamako
2010-2022
National Institute of Malaria Research
2013-2015
Faculty (United Kingdom)
2013-2015
Mass administration of azithromycin for trachoma control led to a sustained reduction in all-cause mortality among Ethiopian children. Whether the addition monthly sulfadoxine–pyrimethamine plus amodiaquine used seasonal malaria chemoprevention could reduce and morbidity African children was unclear.
Pregnancy malaria (PM) is associated with a proinflammatory immune response characterized by increased levels of cytokines and chemokines such as tumor necrosis factor-α, interferon-γ, interleukin 10 (IL-10), CXCL9. These changes are poor outcomes including low birthweight delivery maternal anemia. However, it unknown if inflammatory pathways during related to pregnancy loss preterm (PTD).Cytokine chemokine were measured in peripheral blood at enrollment, gestational week 30-32, delivery,...
Background Seasonal malaria chemoprevention (SMC), the administration of complete therapeutic courses antimalarials to children aged 3–59 months during transmission season, is a new strategy recommended by World Health Organization (WHO) for control in Sahelian countries such as Mali with seasonal transmission. The highly cost-effective approach reduce burden these areas. Despite substantial benefits SMC on infection and disease, optimal deliver remains be determined. While fixed-point...
Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) given during routine vaccinations is efficacious preventing malaria disease and shows no interaction the vaccines. However, there a fear that IPTi may result rapid increase of parasite resistance to SP. To evaluate impact on SP-resistance point mutations, 22 health sub-districts district Kolokani, Mali, were randomized 1:1 ratio starting December 2006, SP was implemented 11 (intervention zone), while...
Abstract Background Seasonal malaria chemoprevention is widely implemented in Sahel and sub-Sahel countries Africa. Few studies have assessed the impact of SMC on hospital admission death when it health system. This retrospective study seasonal (SMC) hospitalizations deaths children under 5 years age during second year implementation district Ouelessebougou Mali. Methods In February 2017, a survey was conducted to assess admissions two sub-districts where 2015 not implemented. The reviewed...
Background Seasonal malaria chemoprevention (SMC) is now widely deployed in the Sahel, including several countries that are major contributors to global burden of malaria. Consequently, it important understand whether SMC continues provide a high level protection and how might be improved. was evaluated using data from large, household-randomised trial Houndé, Burkina Faso Bougouni, Mali. Methods findings The parent monthly plus either azithromycin (AZ) or placebo, administered as directly...
Abstract Background In malaria-endemic areas, pregnant women and especially first-time mothers are more susceptible to Plasmodium falciparum. Malaria diagnosis is often missed during pregnancy, because many with placental malaria remain asymptomatic or have submicroscopic parasitemia, masking the association between pregnancy outcomes. Severe maternal anemia low birthweight deliveries well-established sequelae, but few studies confirmed relationship infection severe outcomes like perinatal...
In 2012, seasonal malaria chemoprevention (SMC) was recommended as policy for control by the World Health Organization (WHO) in areas of highly transmission across Sahel sub-region Africa along with monitoring drug resistance. We assessed long-term impact SMC on Plasmodium falciparum resistance to sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) over a 3-year period implementation health district Ouelessebougou, Mali.In 8 randomly selected sub-districts Mali, children aged 0-5 years were...
P. falciparum virulence is related to adhesion and sequestration of infected erythrocytes (IE) in deep vascular beds, but the endothelial receptors involved severe malaria remain unclear. In largest ever study clinical isolates, we surveyed freshly collected IE from children under 5 years age Mali identify novel receptors, examined effects host age, hemoglobin type, blood group on levels a panel receptors. Several molecules, including integrin α3β1, VE-cadherin, ICAM-2, junctional molecule-B...
Maternal malaria is a tropical scourge associated with poor pregnancy outcomes. Women become resistant to Plasmodium falciparum as they acquire antibodies the variant surface antigen VAR2CSA, leading vaccine candidate. Because infection may increase VAR2CSA antibody levels and thereby confound analyses of immune protection, gravidity-dependent changes in during after infection, effect on outcomes were evaluated. Pregnant women enrolled longitudinal cohort study mother-infant pairs...
Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited information is available on the pharmacokinetic properties antimalarial drugs in this vulnerable population. We assessed artemether-lumefantrine (AL) clinical efficacy children SAM compared to those without. Children under 5 years age uncomplicated P. falciparum malaria were enrolled between November 2013 January 2015 Mali Niger, one third...
Abstract Background A recent trial of 5920 children in Burkina Faso and Mali showed that the combination seasonal vaccination with RTS,S/AS01 E malaria vaccine (primary series two boosters) chemoprevention (four monthly cycles per year) was markedly more effective than either intervention given alone preventing clinical malaria, severe deaths from malaria. Methods In order to help optimise timing these interventions, data were reanalysed estimate duration protection against provided by when...
Abstract Background To improve tuberculosis (TB) diagnosis, the World Health Organisation (WHO) has called for a non-sputum based triage test to focus TB testing on people with high likelihood of having active pulmonary (TB). Various host or pathogen biomarker-based devices are in design stage and require validity assessment. Host biomarkers have shown promise accurately rule out TB, but further research is required determine generalisability. The TriageTB diagnostic study aims assess...
Background Intermittent preventive treatment of malaria in children (IPTc) is a promising strategy for control. A study conducted Mali 2008 showed that administration three courses IPTc with sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ) at monthly intervals reduced clinical malaria, severe infection by >80% under 5 years age. Here we report the results follow-on undertaken to establish whether who had received would be increased risk during subsequent transmission season. Methods...
Pneumonia is still the leading cause of death among children in Africa, and pneumococcal serotypes 1 5 are frequently isolated from African with invasive disease below age years. The immunogenicity, safety reactogenicity 3-dose primary vaccination 10-valent non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) were evaluated infants Mali Nigeria. In an open, randomized, controlled study, 357 received DTPw-HBV/Hib OPV (PHiD-CV group) or without (control PHiD-CV...
Seasonal malaria chemoprevention (SMC) is a new strategy to reduce burden in young children Sahelian countries. It consists of the administration full treatment courses sulfadoxine–pyrimethamine plus amodiaquine at monthly intervals during season. However, it not clear if there cumulative effect SMC over time on acquisition antibodies antigens. A cross-sectional serosurvey was carried out 1 month after last dose 2016. Children aged 3–4 years were randomly selected from areas where given for...
Mass drug administration (MDA) with azithromycin (AZ) is being considered as a strategy to promote child survival in sub-Saharan Africa, but the mechanism by which AZ reduces mortality unclear. To better understand nature and extent of protection provided AZ, we explored profile time since administration, using data from household-randomized, placebo-controlled trial Burkina Faso Mali.
In malaria-endemic areas, pregnant women are more susceptible to
Primary vaccination with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) was previously shown to be immunogenic and well tolerated in Malian children. Data on booster a fourth consecutive dose of PHiD-CV are available for Europe, Asia Latin America but lacking Africa. The present study evaluated further safety, reactogenicity immunogenicity (booster) PHiD-CV.Low incidences AEs grade 3 intensity (2.1% subjects) were observed. There no...
Abstract Background More than 200 million people live in areas of highly seasonal malaria transmission where Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) was recommended 2012 by WHO. This strategy is now implemented widely protected more 19 children 2018. It previously reported that exposure to SMC reduced antibody levels AMA1, MSP-1 42 CSP, but the duration up three 3 years, had no effect on CSP. Methods In 2017, a cross-sectional survey...
Blood-based biomarkers have been proposed as an alternative to current sputum-based treatment monitoring methods in active tuberculosis (ATB). The aim of this study was validate previously described phenotypic, activation, and cytokine markers response a West African cohort. Whole blood immune responses Mycobacterium ESAT-6/CFP-10 (EC) purified protein derivative (PPD) were measured twenty adults at baseline after 2 months standard TB treatment. Patients classified fast or slow responders...
Abstract Background In sub-Saharan Africa, malaria continues to scourge the population and is primary cause of morbidity mortality in young children pregnant women. As current preventative measures such as intermittent preventive treatment use insecticide-treated nets provide incomplete protection, several vaccines are currently under development, including one specifically prevent pregnancy malaria. Prior conducting vaccine trials, it important obtain background information on poor outcomes...
Abstract Background Malaria and malnutrition remain major problems in Sahel countries, especially young children. The direct effect of on malaria remains poorly understood, may have important implications for control. In this study, nutritional status the association between subsequent incidence symptomatic were examined children Burkina Faso Mali who received either azithromycin or placebo, alongside seasonal chemoprevention. Methods Mid-upper arm circumference (MUAC) was measured all...
Mass administration of azithromycin has reduced mortality in children sub-Saharan Africa but its mode action is not well characterised. A recent trial found that given alongside seasonal malaria chemoprevention was associated with a reduction or hospital admissions young children. We investigated the effect on nutritional status enrolled this study.A total 19 578 Burkina Faso and Mali were randomised to receive either placebo sulfadoxine-pyrimethamine plus amodiaquine monthly for three...