A5044068754- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Malaria Research and Control
- Animal Virus Infections Studies
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Virus-based gene therapy research
- Pneumonia and Respiratory Infections
- Otolaryngology and Infectious Diseases
- Viral Infections and Outbreaks Research
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Lipid Membrane Structure and Behavior
- Phenothiazines and Benzothiazines Synthesis and Activities
- Respiratory viral infections research
- Parasites and Host Interactions
- Computational Drug Discovery Methods
- Emergency and Acute Care Studies
- Bacteriophages and microbial interactions
- Zoonotic diseases and public health
- Child and Adolescent Health
- vaccines and immunoinformatics approaches
- Salmonella and Campylobacter epidemiology
Malaria Consortium
2023-2024
London School of Hygiene & Tropical Medicine
2023-2024
MRC Unit the Gambia
2023-2024
University of Cambridge
2021-2024
Super-resolution optical imaging reveals the accumulation of SARS-CoV-2 nucleocapsid protein at viral replication organelles.
The threat of spillovers coronaviruses associated with the severe acute respiratory syndrome (SARS) from animals to humans necessitates vaccines that offer broader protection sarbecoviruses. By leveraging a viral-genome-informed computational method for selecting immune-optimized and structurally engineered antigens, here we show single antigen based on receptor binding domain spike protein sarbecoviruses elicits broad humoral responses against SARS-CoV-1, SARS-CoV-2, WIV16 RaTG13 in mice,...
Abstract Background Seasonal malaria chemoprevention (SMC) is an effective intervention to prevent in children locations where the burden of high and transmission seasonal. There growing evidence suggesting that SMC with sulfadoxine–pyrimethamine amodiaquine can retain its level effectiveness East Southern Africa despite resistance concerns. This study aims generate on when delivered under programmatic conditions area unknown anti-malarial drug profile Northern Bahr el-Ghazal region South...
The accelerated development of the first generation COVID-19 vaccines has saved millions lives, and potentially more from long-term sequelae SARS-CoV-2 infection. most successful vaccine candidates have used full-length spike protein as an immunogen. As expected RNA viruses, new variants evolved quickly replaced original wild-type SARS-CoV-2, leading to escape natural infection or induced immunity provided by sequence. Next that confer specific targeted broadly neutralising epitopes on...
The novel coronavirus SARS-CoV-2 is the seventh identified human coronavirus. Understanding extent of pre-existing immunity induced by seropositivity to endemic seasonal coronaviruses and impact cross-reactivity on COVID-19 disease progression remains a key research question in immunopathology COVID-2019 disease. This paper describes panel lentiviral pseudotypes bearing spike (S) proteins for each seven (HCoVs), generated under similar conditions optimized high titre production allowing...
Abstract Background Pneumonia remains the leading cause of mortality in under-five children outside neonatal period. Progress has slowed down last decade, necessitating increased efforts to scale up effective pneumonia interventions. Methods We used Lives Saved Tool (LiST), a modelling software for child low- and middle-income settings, prospectively analyse potential impact upscaling interventions Bangladesh, Chad, Ethiopia from 2023 2030. included Haemophilus influenzae type B (Hib)...
Group A Streptococcus (Strep A) bacteria causes a broad spectrum of diseases. The most common manifestations Strep infection are sore throat and pus-producing skin infections such as impetigo. Complications can lead to inflammation in the bones, muscles, joints, internal organs causing acute rheumatic fever heart disease (RHD). In Gambia, RHD burden is thought be very high. However, epidemiological data minimal, control programmes do not exist. This study aimed explore beliefs practices...
Abstract Campylobacter species are the major cause of bacterial gastroenteritis. As there is no effective vaccine, combined with rapid increase in antimicrobial resistant strains, a need to identify new targets for intervention. Essential genes those that necessary growth and/or survival, making these attractive targets. In this study, comprehensive transposon mutant libraries were created six C. jejuni four coli strains and one lari hyointestinalis strain, allowing cannot tolerate insertion...
Abstract Updates of SARS-CoV-2 vaccines are required to generate immunity in the population against constantly evolving variants concerns (VOCs). Here we describe three novel in-silico designed spike-based antigens capable inducing neutralising antibodies across a spectrum VOCs. Three sets utilising pre-Delta (T2_32), and post-Gamma sequence data (T2_35 T2_36) were designed. T2_32 elicited superior responses VOCs compared Wuhan-1 spike antigen DNA prime-boost immunisation regime guinea pigs....
Abstract Of the coronaviruses that have caused zoonotic spill overs in past two decades, diverse group of beta-coronaviruses (β-CoVs) represent greatest threats. Towards achieving broad vaccine protection from these viruses, vaccines composed multiple antigens, each capable eliciting neutralising responses across a subgroup will be required. Utilising novel platform for selecting immune optimized, structurally engineered antigens protective related we demonstrate proof-concept against...
Abstract Despite being the target of extensive research efforts due to COVID-19 pandemic, relatively little is known about dynamics SARS-CoV-2 replication within cells. We investigate and characterise tightly orchestrated sequence events during different stages infection cycle by visualising spatiotemporal four structural proteins at high resolution. The nucleoprotein expressed first accumulates around folded ER membranes in convoluted layers that connect viral RNA foci. find three...
Summary Pneumonia remains the leading cause of mortality in children under five outside neonatal period. Progress has slowed down last decade and increased efforts to scale-up effective pneumonia interventions are needed. We used Lives Saved Tool (LiST), a modelling software for child low- middle- income settings, prospectively analyse potential impact upscaling Bangladesh, Chad, Ethiopia from 2023-2030. Haemophilus influenzae type B (Hib) vaccination, pneumococcal conjugate vaccine (PCV),...
Abstract Background Seasonal malaria chemoprevention (SMC) is an effective intervention to prevent in children locations where the burden of high and transmission seasonal. There growing evidence suggesting that SMC with sulfadoxine-pyrimethamine amodiaquine can retain its level effectiveness East Southern Africa despite resistance concerns. This study aims generate on when delivered under programmatic conditions area unknown antimalarial drug profile Northern Bahr el-Ghazal region South...
Abstract Group A Streptococcus (StrepA) bacteria causes a broad spectrum of diseases. The most common manifestations StrepA infection are sore throat and pus-producing skin infections such as impetigo. Complications lead to inflammation in the bones, muscles, joints, internal organs causing acute rheumatic fever heart disease (RHD). In Gambia, RHD burden is thought be very high. However, epidemiological data minimal, control programmes do not exist. This study aims explore beliefs practices...
<sec> <title>BACKGROUND</title> Seasonal malaria chemoprevention (SMC) is a highly effective community-based intervention to prevent infections caused by Plasmodium falciparum in areas where the burden of high and transmission seasonal. SMC commonly seen as success story Sahel region, however, there are regions east southern Africa seasonal, high. The same decision-making frameworks that were used unlikely be applicable due higher pre-existing resistance drugs used, seasonality...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI