A5079902384- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Ophthalmology and Visual Impairment Studies
- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Retinal and Macular Surgery
- Adipose Tissue and Metabolism
- Ocular and Laser Science Research
- Retinal Diseases and Treatments
- Periodontal Regeneration and Treatments
- Retinal Imaging and Analysis
- Surgical Sutures and Adhesives
- Ocular Disorders and Treatments
- Acne and Rosacea Treatments and Effects
- Medical Malpractice and Liability Issues
- Lipid metabolism and biosynthesis
- Fatty Acid Research and Health
- Digital Imaging in Medicine
- Retinal Development and Disorders
- Bone fractures and treatments
- Connexins and lens biology
Université de Haute-Alsace
2024
Harvard University
2011-2023
Massachusetts Eye and Ear Infirmary
2012-2023
Visions
2023
Boston University
2016-2019
Indiana University – Purdue University Indianapolis
2018
Indiana University School of Medicine
2018
University of Massachusetts Boston
2010-2017
Smith-Kettlewell Eye Research Institute
2017
United States Department of Defense
2016
Purpose.: Photochemical cross-linking of corneal collagen is an evolving treatment for keratoconus and other ectatic disorders. We evaluated by rose bengal plus green light (RGX) in rabbit eyes investigated factors important clinical application. Methods.: Rose (RB, 0.1%) was applied to deepithelialized corneas enucleated 2 minutes. The diffusion distance RB into the stroma measured fluorescence microscopy on frozen sections. RB-stained were exposed (532-nm) 3.3 9.9 minutes (50–150 J/cm2)....
Purpose.: To determine the biocompatibility of a new wireless intraocular pressure (IOP) transducer (WIT) in rabbit eyes and to correlate its measurements with other pressure-measuring devices. Methods.: The WIT is ring-shaped device that allows IOP through radiofrequency. It was implanted into six New Zealand White rabbits after extracapsular lens extraction. A sham eye no used as control. animals were observed examined by microscopy at various intervals up 25 months surgery. measured...
To our knowledge, this is a report of the first implantation wireless intraocular pressure transducer (WIT) in human eye.To preliminary safety data on WIT.In an institutional setting, patient with open-angle glaucoma consented to be recipient WIT one eye interventional study design.The was implanted into ciliary sulcus following extracapsular cataract extraction and "in bag" lens implantation. The monitored postoperatively for 18 months.Any adverse events.There were no complications noted...
To evaluate crosslinking of cornea in vivo using green light activation Rose Bengal (RGX) and assess potential damaging effects the on retina iris.Corneas Dutch belted rabbits were de-epithelialized, then stained with exposed to light, or not further treated. Corneal stiffness was measured by uniaxial tensiometry. Re-epithelialization assessed fluorescein fluorescence. Keratocytes counted hematoxylin eosin (H&E)-stained sections, iris cell damage lactate dehydrogenase staining. Thermal...
Purpose: To propose a new treatment paradigm for chemical burns to the eye - in acute and chronic phases. Methods: Recent laboratory clinical data on biology of are analyzed. Results: Corneal blindness from can now be successfully treated with keratoprosthesis, immediate intermediate bases. Long term outcomes, however, hampered by early retinal damage causing glaucoma. New suggest that rapid diffusion inflammatory cytokines posteriorly (TNF-α, etc) severely ganglion cells. Prompt anti-TNF-α...
The prophylactic intraoperative use of mitomycin-C (MMC) to prevent haze and scarring after excimer laser surface ablation (phototherapeutic/photorefractive keratectomy [PTK/PRK]) in an eye with a previous situ keratomileusis (LASIK) flap buttonhole epithelial ingrowth is described. A well-centered measuring 2.0 mm diameter was cut within thin LASIK amblyopic eye. Over the next 8 weeks, corneal progressive formed centrally. An early transepithelial PTK/PRK approach chosen manage together...
The goal of this study was to review cataract surgery outcomes at three independent treatment centres established by the UK Specialist Hospitals (UKSH) and compare these with recognised benchmarks.All patients who underwent UKSH between July 2005 March 2013 were included. Complication rates obtained using annual quality reports, logbooks kept in operating theatres outpatient departments, electronic medical records. Refractive biometry results December 2010 from Results compared previously...
The adipocyte fatty acid-binding protein, aP2 or ALBP, is an abundant cytosolic protein postulated to function in binding and intracellular transport of long-chain acids.In this report, we investigated levels mRNA transcriptional activity the gene tissues from streptozotocin-diabetic rats at different time periods following induction diabetes.An average 75% decrease for (relative 8-actin) was observed all diabetic 7 days post-STZ injection.Insulin supplementation rapidly (2 h) restored...
Purpose: The purpose of this study was to evaluate the resistance degradation by collagenase A corneas that have been crosslinked with Rose Bengal and green light (RGX). Methods: ex vivo crosslinking procedure performed on enucleated rabbit corneas. Corneas were deepithelialized after applying 30% alcohol. stained (RB, 0.1%) for 2 minutes then exposed (532 nm) at 0.25 W/cm2 times deliver doses 50, 100, 150, or 200 J/cm2 (n = 5 per group). Five pretreated riboflavin solution (0.1% riboflavin)...
We present a case of corneal perforation secondary to an intrastromal astigmatic keratotomy performed with optical coherence tomography-guided femtosecond laser. The was concomitant cataract surgery and resulted in flat anterior chamber prior the start lens extraction. Interrupted nylon sutures were placed seal phacoemulsification. Escape cavitation bubbles into or liquid interface can alert surgeon possibility unintended endothelium epithelium, respectively.Neither author has financial...
ObjectiveTo describe the potential acuity pinhole (PAP) test and compare its accuracy to meter (PAM) in predicting visual outcome after cataract surgery.Study designProspective case series.ParticipantsA total of 56 preoperative patients with cataracts participated.Main measuresAccuracy postoperative distance was measured.MethodsLines inaccuracy were calculated by subtracting actual best-corrected (BCVA) from predicted values. Variables analyzed method prediction, BCVA, spherical...
To report the classification, management, and visual outcomes after laser in situ keratomileusis (LASIK) flap buttonhole caused by a microkeratome cut.Private practice, Boston, Massachusetts, USA.This retrospective observational case series comprised 15 patients with an intraoperative LASIK or near buttonhole. In all cases, was left place repositioned without excimer treatment. Buttonholes were classified stage, treatment algorithm based on stage devised to determine timing type of...
Purpose: To present an autonomous intraocular pressure (IOP) measurement technique using a wireless implantable transducer (WIT) and motion sensor. Methods: The WIT optical aid was implanted within the ciliary sulcus of normotensive rabbit eye after extracapsular clear lens extraction. An data system (AWDS) comprising external antenna aided by sensor provided continuous IOP readings. sensitivity determined ability to detect changes resulting from administration latanoprost 0.005% or...
To identify risks factors for retreatment post-laser in situ keratomeliusis (LASIK).A retrospective chart review from December 2008 to September 2012 identified 1,402 patients (2,581 eyes) that underwent LASIK treatment myopia with the Intralase™ FS, STAR S4 IR™ Excimer Laser, and WaveScan WaveFront™ technology. In this group, 83 were retreated. All charts reviewed preoperative age, gender, initial manifest refraction spherical equivalent (MRSE), total astigmatism, iris...
To characterise the emergence pattern of cavitation bubbles into anterior chamber (AC) following femtosecond laser-assisted in situ keratomileusis (LASIK)-flap creationRetrospective review patients undergoing LASIK surgery at Boston Laser, a private refractive practice Boston, Massachusetts, between December 2008 and February 2014. Patient charts were reviewed to identify all cases with gas bubble migration AC. Surgical videos examined location entry was recorded separately for right left...