A5079526604- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Caveolin-1 and cellular processes
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Brain Metastases and Treatment
- TGF-β signaling in diseases
- Ovarian cancer diagnosis and treatment
- Peptidase Inhibition and Analysis
- Bone health and treatments
- Proteoglycans and glycosaminoglycans research
- Growth Hormone and Insulin-like Growth Factors
- Immune cells in cancer
- Fibroblast Growth Factor Research
- Chemokine receptors and signaling
- Cancer Research and Treatments
- Bone Metabolism and Diseases
- Cancer, Lipids, and Metabolism
- Toxin Mechanisms and Immunotoxins
- Mitochondrial Function and Pathology
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Transgenic Plants and Applications
- Plant tissue culture and regeneration
MSH Medical School Hamburg – University of Applied Sciences and Medical University
2022-2024
University Medical Center Hamburg-Eppendorf
2016-2023
Universität Hamburg
2016-2023
HAW Hamburg
2023
University Cancer Center Hamburg
2018-2022
Morpho (United States)
2018
Ovarian cancer disseminates primarily intraperitoneally. Detached tumor cell aggregates (spheroids) from the primary are regarded as ‘metastatic units’ that exhibit a low sensitivity to classical chemotherapy, probably due their unique molecular characteristics. We have analyzed cellular composition of ascites OvCa patients, using flow cytometry, and studied behavior in vitro vivo . conclude ascites‐derived cultured cells patients give rise two subpopulations: adherent non‐adherent cells....
Extravasation of circulating tumor cells (CTCs) is critical for metastasis and initiated by adhesive interactions between glycoligands on CTCs E-selectin endothelia. Here, we show that the clinically approved proteasome inhibitor bortezomib (BZM; Velcade) counteracts cytokine-dependent induction in lung mediated primary tumor, thereby impairing endothelial adhesion thus spontaneous vivo. However, efficacy BZM crucially depends cells' ligands, which determine distinct patterns. The canonical...
Abstract Background The immunological composition of the tumor microenvironment has a decisive influence on biological course cancer and is therefore profound clinical relevance. In this study, we analyzed cooperative effects integrin β4 (ITGB4) cells E-/P-selectin endothelial within stroma for regulating growth by shaping local systemic immune environment. Methods We used several preclinical mouse models different solid human types (xenograft syngeneic) to explore role ITGB4 (shRNA-mediated...
Background: Hyaluronan (HA), a component of the extracellular matrix, is frequently increased under pathological conditions including cancer. Not only stroma cells but also cancer themselves synthesize HA, and interaction HA with its cognate receptors promotes malignant progression metastasis. Methods: In present study, deposition in tissue sections was analyzed by hyaluronan-binding protein (HABP) ligand histochemistry 17 borderline tumors 102 primary 20 recurrent ovarian samples. The...
Abstract Background The disruption of epithelial features represents a critical step during breast cancer spread. In this context, the dysregulation desmosomal proteins has been associated with malignant progression and metastasis formation. Curiously, both tumour suppressive pro-metastatic roles have attributed to structures in different entities. present study, we describe role protein desmocollin 2 (DSC2) cancer. Methods We analysed prognostic DSC2 at mRNA level using microarray data,...
Brain metastases (BM) represent a growing problem for breast cancer (BC) patients. Recent studies have demonstrated strong impact of the BC molecular subtype on incidence BM development. This study explores interaction between cells different subtypes and blood–brain barrier (BBB). We compared ability to overcome several steps (adhesion brain endothelium, disruption BBB, invasion through endothelial layer) during cerebral formation, in vitro as well vivo. Further, these BBB was deciphered at...
Understanding the mechanisms regulating human mammary epithelium requires knowledge of cellular constituents this tissue. Different and partially contradictory definitions concepts describing hierarchy have been proposed, including our studies keratins K5 and/or K14 as markers progenitor cells. Furthermore, we others suggested that p53 homolog p63 is a marker breast epithelial stem In investigation, expand previous by testing whether immunohistochemical staining with monospecific...
Breast cancer (BC) is the second-most common cause of brain metastases (BM) and BCBM patients have a reduced quality life poor prognosis. Hyaluronan (HA), in particular hyaluronidase Hyal-1, has been already linked to development BCBM, therefore presents an interesting opportunity develop new effective therapeutic options. HA metabolism was further discovered by CRISPR/Cas9-mediated knockout HYAL1 shRNA-mediated down-regulation HA-receptor CD44 brain-seeking triple-negative breast (TNBC)...
The transcription factor Fra-2 affects the invasive potential of breast cancer cells by dysregulating adhesion molecules in vitro. Previous results suggested that it upregulates expression E- and P-selectin ligands. Such selectin ligands are important members leukocyte cascade, which govern transmigration into stroma host organ metastasis. As so far, no vivo data available, this study was designed to elucidate role a spontaneous metastasis xenograft model.The effect overexpression two stable...
Abstract Most cancer patients ultimately die from the consequences of distant metastases. As metastasis formation consumes energy mitochondria play an important role during this process as they are most cellular organelle to synthesise rich substrate ATP, which provides necessary enable formation. However, also for execution apoptosis, a limits We therefore wanted investigate mitochondrial content in ovarian cells and link its presence patient’s prognosis order analyse two opposing functions...
Abstract Trotz aller Fortschritte in dem molekularen Verständnis bösartiger Tumoren sind die Heilungsaussichten bei den klinisch bedeutsamen wie Lunge, Bauchspeicheldrüse, Dickdarm und Eierstockkrebs letzten Jahrzehnten nicht wesentlich verbessert worden. Das Therapieversagen kann damit erklärt werden, dass diese frühzeitig metastasieren im metastasierten Stadium meistens mehr erfolgreich behandelt werden können. Ohne ein tieferes der Metastasierung dürfte es schwierig sein, hier größere zu...
Breast cancer (BC) is the most frequent female and preferentially metastasizes to bone. The transcription factor TGFB-induced homeobox 1 (TGIF) involved in bone metabolism. However, it not yet known whether TGIF associated with BC metastasis or patient outcome thus of potential interest.TGIF expression was analyzed by immunohistochemistry 1197 formalin-fixed, paraffin-embedded tissue samples from patients treated GAIN (German Adjuvant Intergroup Node-Positive) study two adjuvant dose-dense...
Abstract Purpose:The transcription factor Fra-2 affects the invasive potential of breast cancer cells by dysregulating adhesion molecules in vitro . Previous results suggested that it upregulates expression E- and P-selectin ligands. Such selectin ligands are important members leukocyte cascade, which govern transmigration into stroma host organ metastasis. As so far, no vivo data available, this study was designed to elucidate role a spontaneous metastasis xenograft model. Methods:The...
Abstract Background: Breast cancer (BC) is the most frequent female its which preferentially metastasizes to bone. Mechanisms of bone tropism are poorly understood, however, transcription factor TGFB-induced homeobox 1 (TGIF) involved in metabolism and thus potential interest. Methods: TGIF expression was analyzed by immunohistochemistry 1197 formalin-fixed, paraffin-embedded tissue from BC patients treated GAIN study with two adjuvant dose-dense schedules chemotherapy or without...
Zusammenfassung Die Mistel, ein auf Bäumen wachsender, immergrüner Halbschmarotzer, beeindruckt mit ihrer einzigartigen Erscheinung, weltweiten Verbreitung und der Vielfalt Inhalts‐ Wirkstoffe. Erst in Neuzeit fand die Mistel ihren Wirkstoffen den Weg unkonventionelle schließlich molekulare Medizin. Das Wirkstoffspektrum wird anhand umfassend erforschten Europäischen ( Viscum album ) dargestellt.