A5055021806- Protein Hydrolysis and Bioactive Peptides
- Probiotics and Fermented Foods
- Plant Genetic and Mutation Studies
- Muscle metabolism and nutrition
- Meat and Animal Product Quality
- Photosynthetic Processes and Mechanisms
- Wheat and Barley Genetics and Pathology
- Plant tissue culture and regeneration
- DNA Repair Mechanisms
- Gut microbiota and health
- Genetic Mapping and Diversity in Plants and Animals
- Plant Molecular Biology Research
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- Insect Utilization and Effects
- Biochemical effects in animals
- Plant nutrient uptake and metabolism
- Metabolomics and Mass Spectrometry Studies
Beijing VDJBio (China)
2024
Ghent University
2014
Vlaams Instituut voor Biotechnologie
2014
VIB-UGent Center for Plant Systems Biology
2014
Nanjing Agricultural University
2007-2009
Abstract Whereas our knowledge about the diverse pathways aiding DNA repair upon genome damage is steadily increasing, little known molecular players that adjust plant cell cycle in response to stress. By a meta-analysis of stress microarray data sets, three family members SIAMESE/SIAMESE-RELATED (SIM/SMR) class cyclin-dependent kinase inhibitors were discovered react strongly genotoxicity. Transcriptional reporter constructs corroborated specific and strong activation SIM/SMR genes...
Abstract The majority of research on cell cycle regulation is focused the nuclear events that govern replication and segregation genome between two daughter cells. However, eukaryotic cells contain several compartmentalized organelles with specialized functions, coordination among these required for proper progression, as evidenced by isolation mutants in which both organelle function overall plant development were affected. To investigate how chloroplast dysfunction affects cycle, we...
In this study, yak bone collagen hydrolysate (YBCH) was produced by mixed proteases and provided to standard-diet mice at a different dose (low (LD), medium (MD), high (HD)) investigate its effects on the composition of gut microbiota short-chain fatty acids (SCFA) production. It found that YBCH mainly composed small molecular peptides whose weight below 2000 Da. Notably, supplementation with doses could significantly downregulate ratio Firmicutes Bacteroidetes in fecal microbiota. At family...
The mature wheat embryo is arguably one of the best explants for genetic transformation because its unlimited availability and lack growth season restriction. However, an efficient regeneration system using embryos (Triticum aestivum L.) still not available. To identify genes related to tissue culture response (TCR) wheat, QTLs callus induction from were mapped RIL population derived cross 'Wangshuibai' with 'Nanda2419', which has a good TCR. By whole genome scanning we identified five, four...
A novel angiotensin-converting enzyme (ACE) inhibitory peptide ser-ala-ser-val-ile-pro-val-ser-ala-val-arg-ala (SASVIPVSAVRA) was purified and identified from yak bone by Electrospray Ionization-Time of Flight-Mass Spectrometry (ESI-TOF-MS). Results in vitro showed that the exhibited strong ACE inhibition activities with an IC 50 54.22 μM. Molecular docking results binding between SASVIPVSAVRA mainly driven van der Waals forces, hydrogen bonds metal receptor. Interestingly, increased about...
<title>Abstract</title> The conserved hemagglutinin (HA) stem region is widely regarded as a highly promising target for the development of universal influenza vaccine. Through structure-based design and iterative mutagenesis screening, we successfully engineered soluble trimeric H1 stem-only protein, designated #219, which does not contain heterologous trimerization motifs thus prevents off-target immune responses. As confirmed by 2.97 Å-resolution cryo-EM structure, overall conformation...
A novel peptide PYPYEPYEPYPY from Yak bone hydrolysate (YBG) was purified by Sephadex G-25, RP-HPLC and identified ESI-TOF-MS. The exhibited some antioxidant activity in HepG2 cells the dipeptidyl peptidase IV (DPP-IV) inhibition activities vivo. In cells, when concentration of 20–160 µM, it could increase half-lethal rate (LD50) showed cytoprotective effect, while at 20–40 µM reduced reactive oxygen species (ROS) content. highest DPP-IV with IC50 value 189.4 among nine peptides YBG....