A5000667966- Nerve injury and regeneration
- Tissue Engineering and Regenerative Medicine
- Spinal Cord Injury Research
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Mesenchymal stem cell research
- Glaucoma and retinal disorders
- Drug-Induced Ocular Toxicity
- Pregnancy and preeclampsia studies
- Muscle Physiology and Disorders
- Sepsis Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Axon Guidance and Neuronal Signaling
- Ocular Diseases and Behçet’s Syndrome
- Birth, Development, and Health
- Bacterial Identification and Susceptibility Testing
- Optical Coherence Tomography Applications
- Cardiac pacing and defibrillation studies
- Neurological Complications and Syndromes
- Elasticity and Material Modeling
- Neutropenia and Cancer Infections
Washington University in St. Louis
2020-2024
Harvard University
2022-2023
University of Michigan
2018-2023
Massachusetts Eye and Ear Infirmary
2023
University of Miami
2021
Saint Louis University
2020
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Engineered heart tissues have been created to study cardiac biology and disease in a setting that more closely mimics vivo muscle than 2D monolayer culture. Previously published studies suggest geometrically anisotropic micro-environments are crucial for inducing “in like” physiology from immature cardiomyocytes. We hypothesized the degree of cardiomyocyte alignment prestress within engineered is regulated by tissue geometry and, subsequently, drives electrophysiological development. Thus,...
Mechanical loading plays a critical role in cardiac pathophysiology. Engineered heart tissues derived from human induced pluripotent stem cells (iPSCs) allow rigorous investigations of the molecular and pathophysiological consequences mechanical cues. However, many engineered muscle models have complex fabrication processes require large cell numbers, making it difficult to use them together with iPSC-derived cardiomyocytes study influence on pharmacology genotype-phenotype relationships. To...
A complex cellular cascade characterizes the pathophysiological response following spinal cord injury (SCI) limiting regeneration. Biomaterial and stem cell combination therapies together have shown synergistic effects, compared to independent benefits of each intervention, represent a promising approach towards regaining function after injury. In this study, we combine our polyethylene glycol (PEG) delivery platform with lentiviral-mediated overexpression anti-inflammatory cytokine...
An important role of neural stem cell transplantation is repopulating and glial cells that actively promote repair following spinal cord injury (SCI). However, survival after severely hampered by the inflammatory environment arises SCI. Biomaterials have a demonstrated history managing post-SCI inflammation can serve as vehicle for delivery. In this study, we utilize macroporous polyethylene glycol (PEG) tubes, which were previously found to modulate microenvironment, viable, soft substrate...
Following spinal cord injury (SCI), function is lost below the level of due to axon damage and demyelination. Spinal progenitors, more broadly neural stem cells, can promote growth axons through multiple mechanisms, yet their poor survival following transplantation has been limiting ability obtain functional effects. In this study, we investigated multichannel poly(lactide-co-glycolide) bridges, which reduce inflammation regrowth, as a support for progenitor at epicenter. Specifically,...
Abstract Spinal cord injury (SCI) results in paralysis below the and strategies are being developed that support axonal regrowth, yet recovery lags, part, because many axons not remyelinated. Herein, we investigated to increase myelination of regenerating by overexpression platelet‐derived growth factor (PDGF)‐AA noggin either alone or combination a mouse SCI model. Noggin PDGF‐AA have been identified as factors enhance recruitment differentiation endogenous progenitors promote myelination....
Spinal cord injury (SCI) is a devastating condition that may cause permanent functional loss below the level of injury, including paralysis and bladder, bowel, sexual function. Patients are rarely treated immediately, this delay associated with tissue scar formation can make regeneration at chronic time points more challenging. Herein, we investigated using poly(lactide-co-glycolide) multichannel bridge implanted into SCI following surgical resection necrotic tissue. We characterized dynamic...
To evaluate the association between widefield swept-source optical coherence tomography angiography (WF SS-OCTA) and visual function in healthy eyes.
US$18141 (US and Rest of World), € 11707 (Europe), £ 9260 (UK
Abstract Engineered heart tissues have been created to study cardiac biology and disease in a setting that more closely mimics in-vivo muscle than 2D monolayer culture. Previously published studies suggest geometrically anisotropic micro-environments are crucial for inducing “ vivo -like” physiology from immature cardiomyocytes. We hypothesized such tissue geometries regulate prestress, turn this prestress is major factor regulating cardiomyocytes’ electrophysiological development. Thus, we...
The patient, a 58-year-old woman with rheumatoid arthritis, presented 6 months of central scotoma and photosensitivity. She had been treated hydroxychloroquine at dosage 400 mg daily for 5 years, then 600 another years. Visual acuity was 20/25 20/30 in the right eye left eye, respectively. A fundus examination autofluorescence revealed characteristic “bull's-eye” pattern parafoveal pigment change both eyes (representative shown color photograph [A] image [B], dark hypofluorescent ring...
Purpose: To describe a novel case of focal exudative retinal detachment, choroidal effusion, and acute angle closure in preeclampsia. Methods: A report is presented. Results: 37-year-old woman at 38 weeks gestation presented with 2 progressive blurred vision the left eye. She had visual acuity (VA) 20/800 an intraocular pressure (IOP) 26 mm Hg eye (compared 17 right eye). Examination showed subretinal fluid posterior pole, ciliochoroidal without pathology was found to have hypertension...
Mechanical loading (e.g. blood pressure) is a critical component of heart disease. Here, we developed simple, scalable iPSC-derived micro muscle (μHM) model by grafting μHM on elastomeric substrates with different stiffnesses to simulate afterload. For tissue traction force microscopy (TFM), were fabricated spin coating PDMS base layer followed an ultra-thin PDMS/fluorescent bead (1-micron) layer. Substrates then covalently grafted fibronectin via glutaraldehyde. Sylgard 184 ‘dog-bone’...
The pathophysiological response following spinal cord injury (SCI) is characterized by a complex cellular cascade that limits regeneration. Biomaterial and stem cell combination therapies have shown synergistic effects, compared to their interventions independent of each other, represent promising approach towards regaining function after injury. In this study, we combine our polyethylene glycol (PEG) delivery platform with lentiviral-mediated overexpression the anti-inflammatory cytokine...