A5102938724- Nuclear physics research studies
- Nuclear Physics and Applications
- Tea Polyphenols and Effects
- Quantum Chromodynamics and Particle Interactions
- Atomic and Subatomic Physics Research
- Quantum, superfluid, helium dynamics
- Particle physics theoretical and experimental studies
- Nuclear reactor physics and engineering
- Radiation Detection and Scintillator Technologies
- MicroRNA in disease regulation
- Advanced NMR Techniques and Applications
- Atomic and Molecular Physics
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Particle Detector Development and Performance
- Phytoestrogen effects and research
- Radiation Therapy and Dosimetry
- Phytochemicals and Antioxidant Activities
- Neutrino Physics Research
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
Ehime University
2022-2025
Osaka Red Cross Hospital
2023-2024
Osaka University
2020-2023
Kyushu University
2013-2023
RIKEN Center for Advanced Photonics
2021
Kyoto University
2014-2020
The Ras/Raf/MEK/ERK pathway has been identified as a major, druggable regulator of melanoma. Mutational activation BRAF is the most prevalent genetic alteration in human melanoma, resulting constitutive melanoma hyperproliferation. A selective inhibitor showed remarkable clinical activity patients with mutated BRAF. Unfortunately, acquire resistance to inhibitor, highlighting urgent need for new treatment strategies. Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) inhibits cell...
Toll-like receptor 4 (TLR4) plays an essential role in innate immunity through inflammatory cytokine induction. Recent studies demonstrated that the abnormal activation of TLR4 has a pivotal obesity-induced inflammation, which is associated with several diseases, including hyperinsulinemia, hypertriglyceridemia, and cardiovascular disease. Here we demonstrate (−)-epigallocatechin-3-O-gallate, natural agonist 67-kDa laminin (67LR), suppressed expression E3 ubiquitin-protein ring finger...
We conducted the coincidence measurement of $\alpha$ particles inelastically scattered from ${}^{20}$Ne at $0^{\circ}$ and decay charged in order to search for alpha-particle condensed state. compared measured excitation-energy spectrum branching ratio with statistical-decay-model calculations, found that newly observed states $E_x$ = 23.6, 21.8, 21.2 MeV are strongly coupled a candidate 4$\alpha$ state ${}^{16}$O. This result presents first strong evidence these candidates 5$\alpha$
Background/Objectives: Late epilepsy occurring in the late stage after glioblastoma (GBM) resection is suggested to be caused by increased extracellular glutamate (Glu). To elucidate mechanism underlying postoperative epilepsy, present study aimed investigate expressions and relations of molecules related Glu metabolism tumor tissues from GBM patients cultured glioma stem-like cells (GSCs). Methods: Expressions CD44, xCT excitatory amino acid transporter (EAAT) 2 concentration with without...
(−)‐Epigallocatechin‐3‐ O ‐gallate (EGCG), a polyphenol in green tea, induces apoptosis acute myeloid leukemia (AML) cells without affecting normal cells. In this study, we observed that cGMP acts as cell death mediator of the EGCG‐induced anti‐AML effect through acid sphingomyelinase activation. EGCG activated Akt/eNOS axis, well‐known mechanism vascular upregulation. We also major negative regulator, phosphodiesterase 5, was overexpressed AML cells, and PDE5 inhibitor, an anti‐erectile...
The cross sections of the Be7(n,α)He4 reaction for p-wave neutrons were experimentally determined at Ec.m.=0.20–0.81 MeV slightly above big bang nucleosynthesis (BBN) energy window first time on basis detailed balance principle by measuring time-reverse reaction. obtained are much larger than s-wave inferred from recent measurement n_TOF facility in CERN, but significantly smaller theoretical estimation widely used BBN calculations. present results suggest rate is not large enough to solve...
Delphinidin, one of the major anthocyanidins, shows protective effects against a variety pathologies, including cancer, inflammation, and muscle atrophy. The purpose this study was to determine preventive mechanism delphinidin on disuse In vitro in vivo models were used validate expression MuRF1, miR-23a, NFATc3. Delphinidin suppressed upregulation MuRF1 (1.77 ± 0.05 vs 1.03 0.17, P < 0.05) inhibited downregulation miR-23a (0.56 0.94 0.06, NFATc3 (0.61 0.02 1.02 0.08, 0.01)...
Quercetin, a flavonol present in many vegetables and fruits, has been identified as chemoprevention agent several cancer models. However, the molecular mechanism of quercetin's anticancer activity is not entirely understood. MicroRNAs (miRNAs), small noncoding RNAs, have reported to play key roles various biological processes by regulating their target genes. We hypothesized that quercetin can exert an effect through regulation miRNAs. To test this hypothesis, we investigated effects on...
Abstract Green tea extract (GTE) induces apoptosis of cancer cells without adversely affecting normal cells. Several clinical trials reported that GTE was well tolerated and had potential anti-cancer efficacy. Epigallocatechin-3- O -gallate (EGCG) is the primary compound responsible for effect GTE; however, EGCG alone limited. To identify compounds capable potentiating bioactivity, we performed metabolic profiling 43 green cultivar panels by liquid chromatography–mass spectrometry (LC–MS)....
An epidemiological study showed that green tea consumption is associated with a reduced risk of hematopoietic malignancy. The major polyphenol epigallocatechin‑3-O-gallate (EGCG) reported to have anticancer effects. Chronic myeloid leukemia (CML) malignancy characterized by expansion cells. In the present study, we EGCG-induced acid sphingomyelinase (ASM) activation and lipid raft clustering in CML ASM inhibitor desipramine significantly cell death. Protein kinase Cδ well‑known plays an...
We systematically measured the differential cross sections of inelastic α scattering off self-conjugate A=4n nuclei at two incident energies Eα=130MeV and 386MeV Research Center for Nuclear Physics, Osaka University. The were analyzed by distorted-wave Born-approximation (DWBA) calculation using single-folding potentials, which are obtained folding macroscopic transition densities with phenomenological αN interaction. DWBA density-dependent interaction overestimates ΔL=0 transitions....
"Why are the tin isotopes soft?" has remained, for past decade, an open problem in nuclear structure physics: models which reproduce isoscalar giant monopole resonance (ISGMR) "doubly-closed shell" nuclei, 90Zr and 208Pb, overestimate ISGMR energies of open-shell cadmium by as much 1 MeV. In effort to shed some light onto this problem, we present results detailed studies molybdenum with goal elucidating where–and how–the softness manifests itself between isotopes. The experiment was...
The triple alpha reaction is one of the most important reactions in nuclear astrophysics. However, its rate high temperature environments at T9> 2 was still uncertain. One major origins uncertainty that radiative-decay probability 31− state 12C unknown. In present work, we have determined to be 1.3−1.1+1.2×10−6 by measuring 1H(12C,12Cp) for first time, and derived from measured probability. result suggests noticeably enhances although contribution had been assumed small.
Abstract Green tea and its major polyphenol epigallocatechin-3- O -gallate (EGCG) have suppressive effect on dietary obesity. However, it remains unsolved what type of diet which they exhibit high or low anti-obesity effect. In the present study, we investigated whether green differs depending composition fats fatty acids that consist high-fat (HF) in mouse model. extract (GTE) intake dramatically suppressed weight gain fat accumulation induced by olive oil-based HF diet, whereas effects...
Delphinidin is a member of the anthocyanidin class plant pigments. We examined effects delphinidin on muscle atrophy. Oral administration suppressed weight loss induced by mechanical unloading. Microarray analysis showed that suppresses upregulation oxidative stress-related gene expression, including expression Cbl-b. Thus, may prevent unloading-mediated
Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) is a powerful technique for visualizing the distribution of wide range biomolecules within tissue sections. However, methodology bioactive ellagitannin has not yet been established. This paper presents novel in situ label-free MALDI-MSI strictinin, found green tea, mammalian kidney after oral dosing. Among nine representative matrix candidates, 1,5-diaminonaphthalene (1,5-DAN), harmane, and ferulic acid showed...
Although the major green tea catechins can inhibit activity of carbohydrate-hydrolyzing enzymes, there is a paucity information describing potential other ingredients and numerous cultivars. Herein, we reveled that cultivar Sunrouge significantly suppressed postprandial blood glucose level in mice. Unlike most representative Japanese cultivar, Yabukita, suppression by was observed clearly during initial period after oral dosing starch. also strongly inhibited enzymes α-glucosidase α-amylase...
As pulmonary fibrosis (PF), a severe interstitial disease, has such poor prognosis, the development of prevention and treatment methods is imperative. (-)-Epigallocatechin-3-O-gallate (EGCG), one major catechins in green tea, exerts an antifibrotic effect, although its mechanism remains unclear. Recently, it been reported that microRNAs (miRNAs or miRs) transported by extracellular vesicles (EVs) from vascular endothelial cells (VECs) are involved PF. In present study, effects EGCG on...
We searched for the 6$α$-condensed state in $^{24}$Mg by measuring $^{12}\rm{C}+{}^{12}\rm{C}$ scattering with SAKRA Si detector array at $E_\rm{cm}$ = 17.5-25.0 MeV. By using invariant-mass method detected 3$α$ particles, inclusive cross sections $^{12}\rm{C}+{}^{12}\rm{C}\to{}^{12}\rm{C}(0^+_2)+X$ and $^{12}\rm{C}(3^-_1)+X$ reactions were determined. In addition, missing-mass spectroscopy was successfully utilized to determine excitation energy of residual $^{12}\rm{C}$ nucleus exclusive...