A5111871289- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Interference and Gene Delivery
- Sarcoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Renal cell carcinoma treatment
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Cancer, Stress, Anesthesia, and Immune Response
- Power Systems Fault Detection
- Connexins and lens biology
- Medicinal Plant Pharmacodynamics Research
- Diabetes Treatment and Management
- Neurological Disease Mechanisms and Treatments
- Acupuncture Treatment Research Studies
First Affiliated Hospital of Soochow University
2022-2025
Anhui Medical University
2015-2025
Soochow University
2015-2025
First Affiliated Hospital of Anhui Medical University
2019-2025
Chinese Academy of Forestry
2025
Jinzhou Medical University
2024
Nanjing Medical University
2011-2023
Shanghai Jiao Tong University
2023
Jiangsu Province Hospital
2023
State Grid Corporation of China (China)
2023
MYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. has been demonstrated drive disease progression hormonal therapeutic resistance of NEPC/CRPC. Here, we aim identify the molecular mechanisms underlying N-Myc-driven provide new targets for those overexpressed overexpressing stable cell lines LNCaP C4–2 were generated by lentivirus infection. ADT-induced senescence was measured SA-β-gal staining cells vitro xenograft tumors vivo....
Significance We report that androgen receptor (AR) promotes glutaminase 1 (GLS1) expression and glutamine utilization to support the survival of prostate cancer (PCa) cells. Hormonal therapy inhibits AR decreases GLS1 achieve therapeutic effect. Our results suggest eventually tumor cells switch from AR-dependent KGA isoform androgen-independent enzymatically more potent GAC isoform, which increases can contribute development castration-resistant PCa. work has discovered a previously unknown...
Background Locoregional therapy combined with systemic can further improve the prognoses for HCC. However, efficacy of TACE ICIs and TKIs HCC whether this triple activate immune response are still unknown. Purpose To identify TACE+ICIs+TKIs unresectable hepatocellular carcinoma (uHCC) its effect on immunity. Materials Methods This single-center retrospective study was approved by Institutional Review Board. From August 1, 2019, to March 30, 2021, patients uHCC who received combination were...
Prostate cancer (PCa) is a prevalent malignancy among men, with majority of patients presenting distant metastases at the time initial diagnosis. These are heightened risk developing more aggressive castration‑resistant PCa following androgen deprivation therapy, which poses greater challenge for treatment. Notably, inhibition tumor angiogenesis should not be considered an ineffective treatment strategy. The regulatory role CDK12 in transcriptional and post‑transcriptional processes...
DIRAS family GTPase 1 (DIRAS1) has been reported as a potential tumor suppressor in other human cancer. However, its expression pattern and role cervical cancer remain unknown. Knockdown of DIRAS1 significantly promoted the proliferation, growth, migration, invasion C33A SiHa cells cultured vitro. Overexpression inhibited viability motility cells. Compared with normal tissues, mRNA levels were lower tissues. protein was also reduced tissues compared para-cancerous In addition, level...
Abstract Diabetic nephropathy (DN) is characterized by glomerular basement membrane (GBM) thickening, primarily due to the abnormal accumulation of collagen type IV (COL4) in extracellular matrix (ECM) podocytes. Podocytes endocytosis crucial for maintaining COL4 balance and GBM integrity. Previous studies have shown that G protein-coupled receptor 107 (GPR107) facilitates clathrin-dependent transferrin internalization recycling murine embryonic fibroblast cells. Therefore, aim study...
Purpose: To compare the safety and efficacy of hepatic arterial infusion chemotherapy followed by transarterial embolization (HAIC+TAE) to chemoembolization (TACE) for treatment unresectable hepatocellular carcinoma (uHCC). Materials methods: The clinical data patients who received HAIC+TAE or TACE between April 2020 2022 was collected. Propensity score-matching used balance baseline characteristics two groups. Tumor response according mRECIST, median time progression (TTP) overall survival...
Aboveground biomass (AGB) is a key parameter for studying the carbon cycle, evaluating grassland growth, and assessing grass–livestock balance. In this study, we established an optimal inversion model alpine AGB estimated growing-season (July–September) from 2018 to 2022 based on field survey data remote sensing data. We aimed analyze spatiotemporal dynamics of in grasslands its response mechanisms hydrothermal factors, as well explore indirect impacts changes human activities during...
Excessive generation of reactive oxygen species (ROS) in cancer cells is associated with development, but the underlying mechanisms and therapeutic significance remain elusive. In this study, we reported that levels ROS p22phox expression are greatly increased human prostate tissues, knockdown by specific small interfering RNA (siRNA) decreased cells. We also showed stable downregulation inhibited cell proliferation colony formation, which was mediated AKT extracellular signal-regulated...
Although insulin is known to regulate glucose metabolism and closely associate with liver cancer, the molecular mechanisms still remain be elucidated. In this study, we attempt understand mechanism of in promotion cancer metabolism. We found that increased pyruvate kinase M2 (PKM2) expression through reactive oxygen species (ROS) for regulating consumption lactate production, key process glycolysis hepatocellular carcinoma HepG2 Bel7402 cells. Interestingly, insulin-induced ROS was...
Purpose: Tientsin Albino 2 (TA2) mice have a high incidence of spontaneous breast cancer. Tumor initiation is related to mouse mammary tumor virus (MMTV) infection. MMTV hormonally regulated and may promote formation via Wnt/β-catenin signaling pathway. This study attempts clarify the relationship between β-catenin expression metastasis cancer in TA2 mice. Materials Methods: Pathological samples illustrating development were collected presence particles was verified tissue by electron...
Existing data suggests a potential link between human blood metabolites and sepsis, yet the precise cause-and-effect relationship remains elusive. By using two-sample Mendelian randomization (MR) analysis, this study aims to establish causal sepsis.A MR analysis was employed investigate sepsis. To assess connection sepsis metabolites, five different methods were employed, A variety of sensitivity analyses conducted, including Cochrane's Q test, MR-Egger intercept MR-PRESSO leave-one-out...
Prostate cancer at advanced stages including metastatic and castration-resistant remains incurable due to the lack of effective therapies. MiR-190a belongs small noncoding RNA family has an important role in breast metastasis. However, it is still unknown whether miR-190a plays a prostate development. Herein, we first observed AR/miR-190a/YB-1 forms auto-regulatory negative feedback loop cancer: expression was down-regulated by AR activation; YB-1 functions are as activator; inhibited...
Although patients with early localized prostate cancer can survive longer, castration-resistant (CRPC) has gradually emerged the use of androgen deprivation therapy (ADT). N-Myc and TEM8 play a vital role in progression several types. However, underlying mechanism how promote remains unclear. In this study, expression was detected benign prostatic hyperplasia (BPH) (PCa) tissues by immunohistochemistry (IHC). LNCaP cell lines were maintained RPMI 1640 medium supplemented 10%...
AIM:To investigate the expression of vascular endothelial cell growth factor (VEGF) and its receptors Fmslike tyrosine kinase 1 (FLT-1) fetal liver (FLK-1) in colorectal carcinoma (CRC), blocking effects small interfering RNAs (siRNAs) on VEGF human cancer HCT116 cells. METHODS:Immunohistochemical staining for VEGF, FLT-1 FLK-1 proteins was performed 82 cases CRC 14 normal mucosae.A siRNA targeting synthesized transfected into cells using lipofectamine 2000.Immunocytochemical Western...
Abstract Rationale: Prostatic urothelial carcinoma is a rare disease. Medical misdiagnosis rates remain high because there are no specific clinical symptoms or imaging features, which decreases patient survival. We report case of prostatic urethral cancer confirmed by transrectal ultrasound-guided prostate biopsy an abnormal digital rectal exam. Patient concerns: A 55-year-old man was referred to our hospital due lower urinary tract that lasted for 5 years. Diagnoses and Interventions: On...