A5100457423- Oral microbiology and periodontitis research
- Dental materials and restorations
- Immunotherapy and Immune Responses
- Orthopaedic implants and arthroplasty
- Virus-based gene therapy research
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- Dental Implant Techniques and Outcomes
- Bone and Dental Protein Studies
- Cancer Research and Treatments
- Biosensors and Analytical Detection
- Streptococcal Infections and Treatments
- Rock Mechanics and Modeling
- Antimicrobial Peptides and Activities
- Structural Response to Dynamic Loads
- Colorectal Cancer Treatments and Studies
- High-Velocity Impact and Material Behavior
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Dental Erosion and Treatment
- Multilevel Inverters and Converters
- Silk-based biomaterials and applications
- Ultrasonics and Acoustic Wave Propagation
- NF-κB Signaling Pathways
State Key Laboratory of Oral Diseases
2014-2024
Sichuan University
2015-2024
Xi'an Jiaotong University
2023
Southern University of Science and Technology
2022
Chengdu University of Information Technology
2022
State Key Laboratory of Biotherapy
2013-2021
University of Maryland, Baltimore
2021
Institute of Geographic Sciences and Natural Resources Research
2018
Chinese Academy of Sciences
2018
University of Chinese Academy of Sciences
2018
The cariogenic pathogen Streptococcus mutans effectively utilizes dietary sucrose for the synthesis of exopolysaccharide, which act as a scaffold its biofilm, thus contributing to pathogenicity, environmental stress tolerance, and antimicrobial resistance. two-component system VicRK S. regulates group virulence genes that are associated with biofilm matrix synthesis. Knockout vicX affects formation, oxidative transformation mutans. However, little is known regarding vicX-modulated structural...
Dental caries is a biofilm-dependent disease that largely relies on the ability of Streptococcus mutans to synthesize exopolysaccharides. Although rnc gene suggested be involved in virulence mechanisms many other bacteria, information regarding it S. very limited. Here, we demonstrated deletion or overexpression significantly positively regulated exopolysaccharide synthesis and further altered biofilm formation. Meanwhile, cariogenecity was decreased by specific pathogen-free (SPF) rat...
Abstract The simultaneous increases in blood lactic acid and erythrocytes after intense exercise could suggest a link between lactate the erythropoiesis. However, effects of on erythropoiesis remain to be elucidated. Here, we utilized mouse model determine role this process parallel with studies using leukaemic K562 cells. Treatment cells vitro increased mRNA protein expression haemoglobin genes frequency GPA + Also, haematocrit CD71 − /Ter119 erythroid were observed acid-treated mice, which...
The cariogenic pathogen Streptococcus mutans effectively utilizes dietary sucrose for the synthesis of exopolysaccharides (EPS), which act as a scaffold its biofilm and thus contribute to pathogenicity. Dextranase (Dex), is type glucanase, participates in degradation water-soluble glucan (WSG); however, structural features EPS regulated by dexAgene have received limited attention. Our recent studies reported novel protocols fractionate analyzed characteristics glucans from S biofilms. In...
Conventional buck power factor correction (PFC) converter has the disadvantage of high harmonic currents due to dead zone input current. An improved method, critical-continuous mode control buck-flyback not completely eliminated impact unit on In this article, a single-stage integrated PFC with low total distortion (THD) is proposed and analyzed. With average current control, each can be automatically distributed; therefore, function extremely THD achieved. Furthermore, ratio flyback...
To investigate the effect of air-drying pressure during ceramic primer coating on zirconia/resin bonding and surface characteristics primed zirconia.Two primers (Clearfil Ceramic Primer, CCP, Kuraray Medical Inc. Z-Prime Plus, ZPP, Bisco Inc.) were applied air-abraded zirconia (Katana zirconia, Noritake) dried at 4 different air pressures (0.1-0.4 MPa). The specimens bonded with a resin-based luting agent (SA Luting Cement, Kuraray). Micro-shear bond strengths tested after 3 days water...
Objectives. This study aimed to investigate the influences of N-acetyl cysteine (NAC) on cytotoxicity and mechanical properties Poly-methylmethacrylate (PMMA) dental resins. Methods. Experimental PMMA resin was prepared by incorporating various concentrations NAC (0, 0.15, 0.3, 0.6 0.9 wt.%). MTT assay performed viability human pulp cells after exposure extract with or without NAC. Cell adhesion specimens examined scanning electron microscopy. Degree conversion studied Fourier Transform...
Upon entering host cells, β-coronaviruses specifically induce generation of replication organelles (ROs) from the endoplasmic reticulum (ER) through their nonstructural protein 3 (nsp3) and nsp4 for viral genome transcription replication. The most predominant ROs are double-membrane vesicles (DMVs). ER-resident proteins VMP1 TMEM41B, which form a complex to regulate autophagosome lipid droplet (LD) formation, were recently shown be essential β-coronavirus infection. Here we report that...
Abstract Background The use of adenoviral vector for gene therapy is still an important strategy advanced cancers, however, the lack requisite coxsackie-adenovirus receptor in cancer cells and host immune response to adenovirus limit application vivo. Method We designed antiangiogenic with recombinant PEDF (Ad-PEDF) encapsulated cationic liposome (Ad-PEDF/Liposome), investigated anti-tumor efficacy Ad-PEDF/Liposome complex on inhibition tumor metastasis. Results found that systemic...
A safe and effective adjuvant plays an important role in the development of a vaccine. However, adjuvants licensed for administration humans remain limited. Here, first time, we developed novel combination alum-polysaccharide-HH2 (APH) with potent immunomodulating activities, consisting alum, polysaccharide Escherichia coli synthetic cationic innate defense regulator peptide HH2. The effects APH were examined using NY-ESO-1 protein-based vaccines prophylactic therapeutic models. We further...
Adjuvants are important components of recombinant protein vaccines which often poorly immunogenic. For decades, the search for new vaccine adjuvants has been predominantly empirical. In addition, combinations more than one adjuvant plus antigen have systematically studied. Plasmid DNA containing additional oligodeoxynucleotides with unmethylated CpG motifs (CpG ODN) entrapped in liposomes used as an and shown powerful immunostimulatory functions. our study, combination plasmid 16 ODNs...
Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis, and the antitumor effect adeno-associated virus (AAV)-mediated PEDF expression has been demonstrated in range animal models. The combined treatment low-dose chemotherapy gene therapy inhibits growth solid tumors more effectively than current traditional therapies or alone. In present study, with an AAV2 vector harboring human (hPEDF) combination cisplatin on Lewis lung carcinoma (LLC) mice was assessed. LLC cells...
Asthma is an atopic disorder with increasing frequency and severity in developed nations. Interleukin-13 (IL-13) one of the most critical mediators asthma pathology. In present study, we a vaccine comprised keyhole limpet hemocyanin-mIL-13 heterocomplex immunogen to persistently neutralize excessive endogenous IL-13. Our results showed that IL-13 peptide kinoid could induce sustained high titer IL-13-specific IgG when using aluminum hydroxide as adjuvant, suppress accumulation eosinophils...
A double input capacitively coupled contactless conductivity detector (DIC4D) device which gets higher sensitivity has been described in this paper. The consists of two electrodes and one output electrode. When alternating current (AC) voltages with the same amplitude different phases are imposed on each electrode, equivalent resistance electrode is reduced because interference signals phase angles. For a (C4D), ratio response KCl solution to that distilled water 1.6. However, for DIC4D,...