A5048015133- Multiple Myeloma Research and Treatments
- Bone health and treatments
- Dental Radiography and Imaging
- Pituitary Gland Disorders and Treatments
- Bone and Joint Diseases
- Gestational Trophoblastic Disease Studies
- Peptidase Inhibition and Analysis
- Oral microbiology and periodontitis research
- Adrenal Hormones and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Color Science and Applications
- Bone health and osteoporosis research
- Neuroendocrine Tumor Research Advances
- Bone Metabolism and Diseases
- Adenosine and Purinergic Signaling
- Endodontics and Root Canal Treatments
- Virus-based gene therapy research
- Bone and Dental Protein Studies
- CAR-T cell therapy research
- S100 Proteins and Annexins
- NF-κB Signaling Pathways
- Synthesis and Biological Evaluation
- Dental Health and Care Utilization
- Natural Compounds in Disease Treatment
- Radiopharmaceutical Chemistry and Applications
University of Sheffield
2012-2023
summary Digital image capturing and analysis techniques have been used to measure the colour of teeth compare with spectrophotometric results visual observations. A non‐linear approach was developed and, for range human teeth, allows device‐dependant digital camera data be quantitatively transformed Commission Internationale de l’Éclairage (CIE) colorimetric values. With reference a CIE standard illuminant, two different lighting arrays used. For flat non‐translucent white yellow surfaces,...
Diseases such as osteoporosis are associated with reduced bone mass. Therapies to prevent loss exist, but there few that stimulate formation and restore Bone morphogenetic proteins (BMPs) members of the TGFβ superfamily, which act pleiotropic regulators skeletal organogenesis homeostasis. Ablation BMPR1A receptor in osteoblasts increases mass, suggesting inhibition signaling may have therapeutic benefit. The aim this study was determine effects systemic administration a soluble fusion...
ABSTRACT Multiple myeloma is a plasma cell malignancy, which develops in the bone marrow and frequently leads to severe destruction. Current antiresorptive therapies treat disease do little repair damaged bone; therefore, new treatment strategies incorporating anabolic are urgently required. We hypothesized that combination therapy using standard of care zoledronic acid (Zol) with (anti-TGFβ/1D11) would be more effective at treating myeloma-induced than Zol alone. JJN3 myeloma-bearing mice...
Osteosarcoma (OS) is the most common type of primary bone cancer affecting children and adolescents. OS has a high propensity to spread meaning disease often incurable fatal. There have been no improvements in survival rates for decades. This highlights an urgent need development novel therapeutic strategies. Here, we report vitro vivo data that demonstrates role purinergic signalling, specifically, B isoform receptor P2RX7 (P2RX7B), progression metastasis.TE85 MNNG-HOS cells were...
Cushing's syndrome, which is characterized by excessive circulating glucocorticoid concentrations, may be due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumors, respectively. ACTH secretion stimulated CRH, we report a mouse model for syndrome an N-ethyl-N-nitrosourea (ENU) induced Crh mutation at -120 bp of the promoter region, significantly increased luciferase reporter activity was thus gain-of-function mutation. Crh(-120/+) mice, when...
The Enamel Defects Index (EDI) was created based on three innovative principles: (i) a basic level of the major categories defects; (ii) more detailed subcategories each category; and (iii) category scored independently as present [1] or absent [0], simplifying decision making. aim this investigation to further test index in number applications expand it record defect subtype treatment need. Testing undertaken by operators with different levels clinical experience. A computer-assisted...
ABSTRACT Bisphosphonates are widely used in the treatment of clinical disorders characterized by increased bone resorption, including osteoporosis, Paget's disease, and skeletal complications malignancy. The antiresorptive potency nitrogen-containing bisphosphonates on vivo is now recognized to depend upon two key properties, namely mineral binding affinity inhibitory activity farnesyl pyrophosphate synthase (FPPS), these properties vary independently each other individual bisphosphonates....
Multiple myeloma is a plasma cell malignancy that causes debilitating bone disease and fractures, in which TGFβ plays central role. Current treatments do not repair existing damage fractures remain common occurrence. We developed novel low tumor phase murine model mimicking the plateau patients as we hypothesized this would be an ideal time to treat with anabolic. Using vivo μCT show substantial rapid lesion (and prevention) driven by SD-208 (TGFβ receptor I kinase inhibitor) chemotherapy...
Summary Myeloma bone disease results from an uncoupling of osteoclastic resorption and osteoblastic formation, but early changes in osteogenic function remain poorly defined. We used the KMS12BM xenograft model to investigate cellular molecular events at late stages disease. Lytic lesions osteoblast osteoclast numbers occur (8 weeks), however, micro‐computed tomography femora revealed significant reduction volume earlier (3 weeks) when tumour burden is low. Calcein labelling demonstrated...
Objectives: The aim of this investigation was to compare the accuracy and reproducibility images acquired from two types camera (digital SLR camera, Kodak DCS410, KJP, UK an intra‐oral Schick Technologies, UK) for application within imaging system used quantification disclosed dental plaque. Methods: Subjects refrained brushing their teeth 24 h. Their were then with Erythrosin FDC Red 3 duplicate sets obtained by each examiner upper central lateral incisors. Images saved measured plaque...
Tumor necrosis factor (TNF) is a powerful pro-inflammatory cytokine and immuno-regulatory molecule, modulates susceptibility to musculoskeletal diseases. Several meta-analyses replicated association studies have implicated the minor 'A' variant within TNF promoter single nucleotide polymorphism (SNP) rs361525 (-238A/G) as risk allele in joint related disorders, including psoriatic juvenile idiopathic arthritis, osteolysis after arthroplasty. Here we characterized effect of this on function....
Abstract Aim: The aim of this study was to increase the versatility and further validate method reported by Smith et al. (2001) testing reliability plaque measurement against two well‐known dental quantification methodologies using image analysis in a clinical trial. Method: teeth 40 subjects were disclosed before digital images labial lingual surfaces their upper lower incisors acquired. amount present quantified modification described al . modified for obtaining incorporating use...
The receptor tyrosine kinase c-Met, its ligand HGF, and components of the downstream signalling pathway, have all been implicated in pathogenesis myeloma, both as modulators plasma cell proliferation agents driving osteoclast differentiation osteoblast inhibition thus, these contribute substantially to bone destruction typically caused by myeloma. Patients with elevated levels HGF a poor prognosis, therefore, targeting entities such patients may be substantial benefit. We hypothesized that...
Abstract Multiple myeloma (MM) patients develop osteolysis characterised by excessive osteoclastic bone destruction and lack of osteoblast formation. Pharmacological manipulation monoacylglycerol lipase (MAGL), an enzyme responsible for the degradation endocannabinoid 2-arachidonoyl glycerol (2-AG), reduced skeletal tumour burden associated with osteosarcoma advanced breast prostate cancers. MM hematopoietic, immune marrow cells express high levels type 2 cannabinoid receptor osteoblasts...
Multiple myeloma remains largely incurable due to refractory disease; therefore, novel treatment strategies that are safe and well-tolerated required. Here, we studied the modified herpes simplex virus HSV1716 (SEPREHVIR®), which only replicates in transformed cells. Myeloma cell lines primary patient cells were infected with assessed for death using propidium iodide (PI) Annexin-V staining markers of apoptosis autophagy by qPCR. was associated dual PI positivity increased expression...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)