A5091814870- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Inflammasome and immune disorders
- Malaria Research and Control
- Biological Activity of Diterpenoids and Biflavonoids
- HIV/AIDS drug development and treatment
- Drug Transport and Resistance Mechanisms
- Bioactive Compounds and Antitumor Agents
- Gout, Hyperuricemia, Uric Acid
- NF-κB Signaling Pathways
- interferon and immune responses
- Fungal Biology and Applications
- Phytochemistry and Bioactive Compounds
- Crystallography and molecular interactions
- Wound Healing and Treatments
- Ginger and Zingiberaceae research
- Synthesis and biological activity
- Herpesvirus Infections and Treatments
- Phytochemical Studies and Bioactivities
- Animal Disease Management and Epidemiology
- Toxin Mechanisms and Immunotoxins
- Organic Chemistry Cycloaddition Reactions
- Silk-based biomaterials and applications
Kunming Institute of Botany
2016-2024
Chinese Academy of Sciences
2016-2024
Yunnan University
2017-2022
Center for Life Sciences
2019-2022
Tsinghua University
2020-2022
Beijing Advanced Sciences and Innovation Center
2020-2022
Peking University
2020
Ministry of Education of the People's Republic of China
2018
University of Chinese Academy of Sciences
2016-2018
Kunming University
2018
Callicarpins A–D (1–4), possessing an unprecedented A-homoent-clerodane scaffold with a bicyclo[5.4.0]undecane ring system, and callicarpins E–G (5–7), 5/6-fused ent-clerodane diterpenoid skeletons, were isolated from Callicarpaarborea C. integerrim. Their structures elucidated by comprehensive spectroscopic data, X-ray crystal diffraction, chemical derivatization, electronic circular dichroism (ECD) data. Putative biosynthetic pathways for these are proposed. Compounds 2, 3b, 6–8 showed...
Significance There is an urgent need for alternative antimalarials with the emergence of artemisinin-resistant malaria parasites. Blocking sugar uptake in Plasmodium falciparum by selectively inhibiting hexose transporter P. 1 (PfHT1) kills blood-stage parasites without affecting host cells, making PfHT1 a promising therapeutic target. Here, we report development series small-molecule inhibitors that simultaneously target orthosteric and allosteric binding sites PfHT1. These all exhibit...
We report that phosphorylation of gasdermin D (GSDMD)-NT, cleaved by inflammatory caspases, could inhibit pyroptosis. Phosphatase 1 (PP1) is responsible for the regulation GSDMD and capacity to induce cell death. Our findings reveal a critical regulatory mechanism as it provides insight into pyroptosis processes.
Species belonging to the genus Callicarpa are used traditionally in Chinese medicine for treatment of inflammation, rheumatism, and pain. Investigation leaves twigs bodinieri resulted isolation nine new abietane diterpenoids, bodinieric acids A–I (1–9), along with six known compounds (10–15). The structures 1–9 were elucidated on basis interpretation their HRESIMS NMR data by ECD calculations. To explore potential therapeutic target this plant immune-mediated disease, inhibitory activities...
Premnafulvol A (1), a unique diterpenoid featuring 6/5/7/3-fused tetracyclic carbon skeleton, with three biosynthetically related analogues, premnafulvols B–D (2–4), were isolated from the aerial parts of Premna fulva. Structures 1–4 established by combination extensive spectroscopic analyses, quantum chemical calculations, and X-ray crystallography. Plausible biosynthetic pathways proposed. Interestingly, 2 3 exhibited opposite effects on estrogen biosynthesis in human ovarian...
Fungal drug resistance is a major health threat, and reports of clinical worldwide are becoming increasingly common. In research program to discover new molecules help overcome this problem, 14 lanostane-type triterpenoids, gibbosicolids A–G (2–8) gibbosic acids I–O (9–15), were isolated from the fruiting bodies Ganoderma gibbosum, along with seven known triterpenoid derivatives. These compounds featured high levels oxidation, epimerization, γ-lactonization. Structures elucidated by...
A spiro ent-clerodane homodimer with a rare 6/6/6/6/6-fused pentacyclic scaffold, spiroarborin (1), together four new monomeric analogues (2-5), were isolated from Callicarpa arborea. Their structures elucidated by comprehensive spectroscopic data analysis, quantum-chemical calculations, and X-ray diffraction. plausible biosynthetic pathway of 1 was proposed, biomimetic synthesis its derivative accomplished. Compound showed potent inhibitory effect directly binding to the YEATS domain 11-19...
Investigation of the leaves and stems Premna szemaoensis resulted in isolation twelve new abietane diterpenoids, szemaoenoids A-L (1-12), together with four known diterpenoids (13-16). The structures involved two rearranged-abietane skeletons: 17(15 → 16)-abeo-abietane (7, 10-12, 14 15) 16),18(4 3)-diabeo-abietane (1-6, 13 16). compounds were established mainly by analyzing NMR HRESIMS data. absolute configurations 1, 3 10 confirmed single crystal X-ray diffraction analysis. In bioactivity...
Inflammation causes many diseases that are serious threats to human health. However, the molecular mechanisms underlying regulation of inflammation and inflammasome activation not fully understood which has delayed discovery new anti-inflammatory drugs urgent clinic need. Here, we found natural compound Teuvincenone F, was isolated purified from stems leaves Premna szemaoensis, could significantly inhibit lipopolysaccharide (LPS)-induced pro-inflammatory cytokines production NLRP3...
Abstract Four new dolabellane-type diterpene alkaloids, glandulamines A – D (1 4), together with twelve known compounds (5 16), were isolated from the seeds of Nigella glandulifera using repeated column chromatography and semipreparative HPLC. The structures 1 16 elucidated based on NMR data analysis, HRMS experiments other spectroscopic interpretations. absolute configuration 5 was determined by single-crystal X-ray diffraction for first time. Compounds 10 12 showed human dihydroorotate...
Chemical constituents investigation on the seeds of Machilus yunnanensis led to two new phenolic compounds 8-O-acetyl-phenylethanoid-4-O-β-D-glucopyranoside (1) and (E)-2,3-bis(4-hydroxyphenyl)acrylaldehyde (2), together with 16 known compounds. Their structures were elucidated basis spectroscopic data analysis (IR, MS, 1D, 2D NMR). Meanwhile, 1–3, 6–13, 17, 18 evaluated for vasorelaxant effects rat endothelium-intact thoracic aorta rings precontracted phenylephrine (PE) or KCl. The bioassay...
A novel indigoferamide-A, earlier isolated from the seeds of Indigofera heterantha Wall was characterized using density functional theory, molecular docking and bioassays studies. Density theory calculations were performed at B3LYP/6-31G(d,p) to gain geometric insight compound. Conformational analyses have been around three important dihedral angles explore lowest energy structure conformer. The simulated vibrational spectrum compound scaled with two scaling factors, harmonic vibrations...
Abstract Artemisinin-resistant malaria parasites have emerged and been spreading, posing a significant public health challenge. Anti-malarial drugs with novel mechanisms of action are therefore urgently needed. In this report, we exploit “selective starvation” strategy by selectively inhibiting Plasmodium falciparum hexose transporter 1 (PfHT1), the sole in , over human glucose (hGLUT1), providing an alternative approach to fight against multidrug-resistant parasites. Comparison crystal...
Four new compounds, a dibenzylbutane lignin, plasiaticine F (1), an acetylenic glycoside, G (2), indole alkaloid, H (3), and ionone derivative, I (4), were isolated from the seeds of Plantago asiatica. The structures compounds elucidated on basis comprehensive analysis spectroscopic data. Compounds 1-3 tested for their cytotoxicity, but lacked significant activity.